Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities

Publication date: January 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 1Author(s): Yu-Dan MEI, Nan ZHANG, Wei-Yang ZHANG, Jin-Shan TANG, Hua ZHOU, Yang YU, Xin-Sheng YAOAbstractThe flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1–12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid (1) and 2α, 4α-dihydroxy-23-nor-ursolic acid (2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L−1.

Source: Chinese Journal of Natural Medicines - January 29, 2019 Category: Complementary Medicine Source Type: research