Jatrogricaine A: a new diterpenoid with a 5/6/6/4 carbon ring system from the stems of Jatropha podagrica

Publication date: April 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 4Author(s): Lin CHEN, Jia-Luo HUANG, Lei ZHANG, Hai-Yan TIAN, Sheng YINAbstractJatrogricaine A (1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (2–9) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory activities in vitro, and compound 3 showed significant inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC50 of 13.44 ± 0.28 μmol·L−1, being comparable to the positive control, quercetin (IC50 17.00 ± 2.10 μmol·L−1).
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research