Two new nimbolinin- and trichilin-class limonoids isolated from the fruits of Melia azedarach

Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Lu QIU, Li HENG, Rong XU, Jun LUO, Yi LIAbstractTwo new furan fragment isomerized limonoids, meliazedalides A and B (compounds 1 and 2), were isolated from the fruits of Melia azedarach Linn.. Their chemical structures were elucidated on the basis of HR-ESI-MS and 1D and 2D NMR data, which belonged to nimbolinin- and trichilin-class, respectively. Compound 2 exhibited weak inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages with IC50 being 37.41 μmol·L−1.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research