Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Publication date: April 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 4Author(s): Cheng-Yao MA, Jia-Hui LU, Xiang LI, Xiao LIU, Jian-Wei CHENAbstractEight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research