The Nedd8 ‐activating enzyme inhibitor MLN4924 (TAK‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma
Cell Proliferation, EarlyView. (Source: Cell Proliferation)
Source: Cell Proliferation - October 20, 2018 Category: Cytology Authors: Wenjuan Zhang,
Yupei Liang,
Lihui Li,
Xiaofang Wang,
Zi Yan,
Changsheng Dong,
Mu ‐Sheng Zeng,
Qian Zhong,
Xue‐Kui Liu,
Jinha Yu,
Shuyang Sun,
Xiaojun Liu,
Jihui Kang,
Hu Zhao,
Lak Shin Jeong,
Yanmei Zhang,
Lijun Jia Source Type: research
Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1
Cell Proliferation, EarlyView. (Source: Cell Proliferation)
Source: Cell Proliferation - October 20, 2018 Category: Cytology Authors: Cancan Zhou,
Weikun Qian,
Jiguang Ma,
Liang Cheng,
Zhengdong Jiang,
Bin Yan,
Jie Li,
Wanxing Duan,
Liankang Sun,
Junyu Cao,
Fengfei Wang,
Erxi Wu,
Zheng Wu,
Qingyong Ma,
Xuqi Li Source Type: research
Golgi protein 73 and its diagnostic value in liver diseases
AbstractGolgi protein 73 (GP73, also referred to as Golph 2) with 400 amino acids is a 73 kDa transmembrane glycoprotein typically found in the cis‐Golg complex. It is primarily expressed in epithelial cells, which has been found upregulated in hepatocytes in patients suffering from both viral and non‐viral liver diseases. GP73 has drawn increasing attention for its potential appli cation in the diagnosis of liver diseases such as hepatitis, liver cirrhosis and liver cancer. Herein, we reviewed the discovery history of GP73 and summarized studies by many groups around the world, aiming at understanding its structure,...
Source: Cell Proliferation - October 19, 2018 Category: Cytology Authors: Yanyan Xia,
Yuanying Zhang,
Mengjiao Shen,
Hongpan Xu,
Zhiyang Li,
Nongyue He Tags: REVIEW ARTICLE Source Type: research
Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1
ConclusionsOur data provide evidence that resveratrol reverses the stemness induced by gemcitabine by targeting SREBP1 both in vitro and in vivo. Thus, resveratrol can be an effective chemotherapy sensitizer, and SREBP1 may be a rational therapeutic target. (Source: Cell Proliferation)
Source: Cell Proliferation - October 19, 2018 Category: Cytology Authors: Cancan Zhou,
Weikun Qian,
Jiguang Ma,
Liang Cheng,
Zhengdong Jiang,
Bin Yan,
Jie Li,
Wanxing Duan,
Liankang Sun,
Junyu Cao,
Fengfei Wang,
Erxi Wu,
Zheng Wu,
Qingyong Ma,
Xuqi Li Tags: ORIGINAL ARTICLE Source Type: research
The Nedd8 ‐activating enzyme inhibitor MLN4924 (TAK‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma
ConclusionsThese findings determined the over ‐expression levels of neddylation enzymes in HNSCC and revealed novel mechanisms underlying neddylation inhibition induced growth suppression in HNSCC cells, which provided preclinical evidence for further clinical evaluation of neddylation inhibitors (eg, MLN4924) for the treatment of HNSCC. (Source: Cell Proliferation)
Source: Cell Proliferation - October 19, 2018 Category: Cytology Authors: Wenjuan Zhang,
Yupei Liang,
Lihui Li,
Xiaofang Wang,
Zi Yan,
Changsheng Dong,
Mu ‐Sheng Zeng,
Qian Zhong,
Xue‐Kui Liu,
Jinha Yu,
Shuyang Sun,
Xiaojun Liu,
Jihui Kang,
Hu Zhao,
Lak Shin Jeong,
Yanmei Zhang,
Lijun Jia Tags: ORIGINAL ARTICLE Source Type: research
H19 regulation of oestrogen induction of symmetric division is achieved by antagonizing Let ‐7c in breast cancer stem‐like cells
Cell Proliferation, EarlyView. (Source: Cell Proliferation)
Source: Cell Proliferation - October 19, 2018 Category: Cytology Authors: Meng Wang,
Yuan Li,
Guo ‐Dong Xiao,
Xiao‐Qiang Zheng,
Ji‐Chang Wang,
Chong‐Wen Xu,
Sida Qin,
Hong Ren,
Shou‐Ching Tang,
Xin Sun Source Type: research
The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase ‐mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis
Cell Proliferation, EarlyView. (Source: Cell Proliferation)
Source: Cell Proliferation - October 19, 2018 Category: Cytology Authors: Jingxia Cui,
Shuli Man,
Nina Cui,
Li Yang,
Qianbei Guo,
Long Ma,
Wenyuan Gao Source Type: research
The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase ‐mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis
ConclusionsFormosanin C and PVII showed a synergistic antitumour effect on lung cancer cells. The findings would provide the foundation for the use of combination drugs in the future. (Source: Cell Proliferation)
Source: Cell Proliferation - October 18, 2018 Category: Cytology Authors: Jingxia Cui,
Shuli Man,
Nina Cui,
Li Yang,
Qianbei Guo,
Long Ma,
Wenyuan Gao Tags: ORIGINAL ARTICLE Source Type: research
H19 regulation of oestrogen induction of symmetric division is achieved by antagonizing Let ‐7c in breast cancer stem‐like cells
ConclusionsOur results revealed a previously undescribed double negative feedback loop between sponge H19 and targeted Let ‐7c through oestrogen activated Wnt signalling that dominated in stem cells’ division. (Source: Cell Proliferation)
Source: Cell Proliferation - October 18, 2018 Category: Cytology Authors: Meng Wang,
Yuan Li,
Guo ‐Dong Xiao,
Xiao‐Qiang Zheng,
Ji‐Chang Wang,
Chong‐Wen Xu,
Sida Qin,
Hong Ren,
Shou‐Ching Tang,
Xin Sun Tags: ORIGINAL ARTICLE Source Type: research
MiR ‐34b/c‐5p and the neurokinin‐1 receptor regulate breast cancer cell proliferation and apoptosis
Cell Proliferation, EarlyView. (Source: Cell Proliferation)
Source: Cell Proliferation - October 18, 2018 Category: Cytology Authors: Lufang Zhang,
Lushan Wang,
Dong Dong,
Zhiyong Wang,
Wei Ji,
Man Yu,
Fei Zhang,
Ruifang Niu,
Yunli Zhou Source Type: research
Comparison of different in vitro differentiation conditions for murine female germline stem cells
Cell Proliferation, EarlyView. (Source: Cell Proliferation)
Source: Cell Proliferation - October 18, 2018 Category: Cytology Authors: Kang Zou,
Jian Wang,
Haiwei Bi,
Yabin Zhang,
Xueli Tian,
Ning Tian,
Wanyun Ma,
Ji Wu Source Type: research
Polarity protein Canoe mediates overproliferation via modulation of JNK, Ras ‐MAPK and Hippo signalling
ConclusionsOur work reveals an oncogenic role of Cno and creates a new type ofDrosophila tumour model for cancer research. (Source: Cell Proliferation)
Source: Cell Proliferation - October 17, 2018 Category: Cytology Authors: Zhiwei Ma,
Ping Li,
Xingjie Hu,
Haiyun Song Tags: ORIGINAL ARTICLE Source Type: research
Comparison of different in vitro differentiation conditions for murine female germline stem cells
ConclusionWe evaluated five in vitro differentiation conditions for mFGSCs and successfully differentiate mFGSCs into GV ‐stage oocytes using a three‐step differentiation process. (Source: Cell Proliferation)
Source: Cell Proliferation - October 17, 2018 Category: Cytology Authors: Kang Zou,
Jian Wang,
Haiwei Bi,
Yabin Zhang,
Xueli Tian,
Ning Tian,
Wanyun Ma,
Ji Wu Tags: ORIGINAL ARTICLE Source Type: research
Zyxin ‐involved actin regulation is essential in the maintenance of vinculin focal adhesion and chondrocyte differentiation status
ConclusionsThese results demonstrate supporting evidence that in chondrocytes the level of zyxin is closely associated with the state of actin polymerization. In particular, the change of zyxin and F ‐actin parallels with the change of COL II and vinculin, respectively, indicating a major role of zyxin‐actin interaction in the synthesis of collagen ECM and the remodelling of cytoskeleton‐ECM adhesion. (Source: Cell Proliferation)
Source: Cell Proliferation - October 17, 2018 Category: Cytology Authors: Gaoming Li,
Xiongbo Song,
Rui Li,
Li Sun,
Xiaoyuan Gong,
Cheng Chen,
Liu Yang Tags: ORIGINAL ARTICLE Source Type: research
MiR ‐34b/c‐5p and the neurokinin‐1 receptor regulate breast cancer cell proliferation and apoptosis
ConclusionsMiR ‐34b/c‐5p and NK1R contribute to breast cancer cell proliferation and apoptosis and are potential targets for breast cancer therapeutics. (Source: Cell Proliferation)
Source: Cell Proliferation - October 17, 2018 Category: Cytology Authors: Lufang Zhang,
Lushan Wang,
Dong Dong,
Zhiyong Wang,
Wei Ji,
Man Yu,
Fei Zhang,
Ruifang Niu,
Yunli Zhou Tags: ORIGINAL ARTICLE Source Type: research
