Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1

ConclusionsOur data provide evidence that resveratrol reverses the stemness induced by gemcitabine by targeting SREBP1 both in vitro and in vivo. Thus, resveratrol can be an effective chemotherapy sensitizer, and SREBP1 may be a rational therapeutic target.

Source: Cell Proliferation - October 19, 2018 Category: Cytology Authors: Cancan Zhou, Weikun Qian, Jiguang Ma, Liang Cheng, Zhengdong Jiang, Bin Yan, Jie Li, Wanxing Duan, Liankang Sun, Junyu Cao, Fengfei Wang, Erxi Wu, Zheng Wu, Qingyong Ma, Xuqi Li Tags: ORIGINAL ARTICLE Source Type: research