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Cell Proliferation, Ahead of Print. (Source: Cell Proliferation)
Source: Cell Proliferation - February 5, 2018 Category: Cytology Source Type: research
Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict liver regeneration
ConclusionsCell cycle lesions following mitochondrial and DNA damage led to failure of hepatic regeneration in acetaminophen toxicity but their reversibility offers molecular targets for treating acute liver failure. (Source: Cell Proliferation)
Source: Cell Proliferation - February 1, 2018 Category: Cytology Authors: Preeti Viswanathan, Yogeshwar Sharma, Priya Gupta, Sanjeev Gupta Tags: ORIGINAL ARTICLE Source Type: research
Overcoming resistance to mitochondrial apoptosis by BZML ‐induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells
ConclusionsOur data suggest that the anti‐apoptosis property of A549/Taxol cells originates from a defect in activation of the mitochondrial apoptotic pathway, and autophagy inhibitors can potentiate BZML‐induced MC to overcome resistance to mitochondrial apoptosis. (Source: Cell Proliferation)
Source: Cell Proliferation - February 1, 2018 Category: Cytology Authors: Zhaoshi Bai, Meiqi Gao, Xiaobo Xu, Huijuan Zhang, Jingwen Xu, Qi Guan, Qing Wang, Jianan Du, Zhengqiang Li, Daiying Zuo, Weige Zhang, Yingliang Wu Tags: ORIGINAL ARTICLE Source Type: research
Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma
ConclusionsPharmacological or transcriptional inhibition of HDAC1/2 increases p19INK4d and p21Waf1/Cip1 expression, decreases CDK expression and arrests HCC growth. These results indicated a potential pharmacological mechanism of selective HDAC1/2 inhibitors in HCC therapy. (Source: Cell Proliferation)
Source: Cell Proliferation - February 1, 2018 Category: Cytology Authors: Hengyu Zhou, Ying Cai, Dina Liu, Menghui Li, Yu Sha, Wenlu Zhang, Kai Wang, Jianping Gong, Ni Tang, Ailong Huang, Jie Xia Tags: ORIGINAL ARTICLE Source Type: research
Loss of PPM1F expression predicts tumour recurrence and is negatively regulated by miR ‐590‐3p in gastric cancer
ConclusionPPM1F may function as a suppressive factor and is negatively regulated by miR‐590 in GC. (Source: Cell Proliferation)
Source: Cell Proliferation - February 1, 2018 Category: Cytology Authors: Jing Zhang, Ming Jin, Xiaoyu Chen, Rui Zhang, Yanxia Huang, Hui Liu, Jinshui Zhu Tags: ORIGINAL ARTICLE Source Type: research
Ginsenoside Rh2 inhibits prostate cancer cell growth through suppression of microRNA ‐4295 that activates CDKN1A
ConclusionsGRh2 may inhibit PC cell growth through suppression of microRNA‐4295 that activates CDKN1A. (Source: Cell Proliferation)
Source: Cell Proliferation - February 1, 2018 Category: Cytology Authors: Qiruo Gao, Junhua Zheng Tags: ORIGINAL ARTICLE Source Type: research
PLC γ2 promotes apoptosis while inhibits proliferation in rat hepatocytes through PKCD/JNK MAPK and PKCD/p38 MAPK signalling
ConclusionsThis study showed that PLCγ2 regulates hepatocyte growth through PKCD‐dependently activating p38 MAPK and JNK MAPK pathways; this result was experimentally based on the further exploration of the effect of PLCγ2 on hepatocyte growth in vivo. (Source: Cell Proliferation)
Source: Cell Proliferation - February 1, 2018 Category: Cytology Authors: Xiaoguang Chen, Qiongxia Lv, Jun Ma, Yumei Liu Tags: ORIGINAL ARTICLE Source Type: research
Substrate stiffness regulated migration and invasion ability of adenoid cystic carcinoma cells via RhoA/ROCK pathway
ConclusionsOur results showed that substrate stiffness regulated the activities of MMPs and TIMPs and then modulate migratory and invasive ability of ACC2 cells via RhoA/ROCK pathway. This work indicate that matrix stiffness played an important role in progression of SACC, which not only can help understand the strong invasive ability of SACC, but also suggested that therapeutically targeting matrix stiffness may help reduce migration and invasion of SACC and improve effective therapies. (Source: Cell Proliferation)
Source: Cell Proliferation - February 1, 2018 Category: Cytology Authors: Dan Zhao, Qianshun Li, Mengting Liu, Wenjuan Ma, Tengfei Zhou, Changyue Xue, Xiaoxiao Cai Tags: ORIGINAL ARTICLE Source Type: research
CRNDE: An important oncogenic long non ‐coding RNA in human cancers
Abstract
Aberrant overexpression of long non‐coding RNA CRNDE (Colorectal Neoplasia Differentially Expressed) is confirmed in various human cancers, which is correlated with advanced clinicopathological features and poor prognosis. CRNDE promotes cancer cell proliferation, migration and invasion, and suppresses apoptosis in complicated mechanisms, which result in the initialization and development of human cancers. In this review, we provide an overview of the oncogenic role and potential clinical applications of CRNDE. (Source: Cell Proliferation)
Source: Cell Proliferation - February 1, 2018 Category: Cytology Authors: Jiaming Zhang, Minuo Yin, Gang Peng, Yingchao Zhao Tags: REVIEW ARTICLE Source Type: research
The transient receptor potential vanilloid ‐3 regulates hypoxia‐mediated pulmonary artery smooth muscle cells proliferation via PI3K/AKT signaling pathway
ConclusionsThese findings suggest that TRPV3 is involved in hypoxia‐induced pulmonary vascular remodeling and promotes proliferation of PASMCs and the effect is, at least in part, mediated via the PI3K/AKT pathway. (Source: Cell Proliferation)
Source: Cell Proliferation - January 23, 2018 Category: Cytology Authors: Qianlong Zhang, Yonggang Cao, Qian Luo, Peng Wang, Pilong Shi, Chao Song, Mingyao E, Jing Ren, Bowen Fu, Hongli Sun Tags: ORIGINAL ARTICLE Source Type: research
The transient receptor potential vanilloid ‐3 regulates hypoxia‐mediated pulmonary artery smooth muscle cells proliferation via PI3K/AKT signaling pathway
Cell Proliferation, EarlyView. (Source: Cell Proliferation)
Source: Cell Proliferation - January 22, 2018 Category: Cytology Source Type: research
Extremely low ‐frequency electromagnetic fields accelerates wound healing modulating MMP‐9 and inflammatory cytokines
Cell Proliferation,Volume 51, Issue 2, April 2018. (Source: Cell Proliferation)
Source: Cell Proliferation - January 22, 2018 Category: Cytology Source Type: research
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Cell Proliferation, Ahead of Print. (Source: Cell Proliferation)
Source: Cell Proliferation - January 22, 2018 Category: Cytology Source Type: research
Extremely low ‐frequency electromagnetic fields accelerates wound healing modulating MMP‐9 and inflammatory cytokines
ConclusionsOur results highlight ability of ELF‐EMF to modulate inflammation mediators and keratinocyte proliferation/migration, playing an important role in wound repair. The ELF‐EMF accelerates wound healing modulating expression of the MMP‐9 via Akt/ERK pathway. (Source: Cell Proliferation)
Source: Cell Proliferation - January 22, 2018 Category: Cytology Authors: A. Patruno, A. Ferrone, E. Costantini, S. Franceschelli, M. Pesce, L. Speranza, P. Amerio, C. D'Angelo, M. Felaco, A. Grilli, M. Reale Tags: ORIGINAL ARTICLE Source Type: research
