Cover Image, Volume 51, Issue 6
The cover image is based on the Original ArticleTetrahedral DNA nanostructures facilitate neural stem cell migration via activating RHOA/ROCK2 signalling pathway by Wenjuan Ma et al.,https://doi.org/10.1111/cpr.12503. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Wenjuan Ma,
Xueping Xie,
Xiaoru Shao,
Yuxin Zhang,
Chenchen Mao,
Yuxi Zhan,
Dan Zhao,
Mengting Liu,
Qianshun Li,
Yunfeng Lin Tags: COVER IMAGE Source Type: research
Issue Information
Cell Proliferation, Volume 51, Issue 6, December 2018. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Tags: ISSUE INFORMATION Source Type: research
MiR ‐139‐5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma
ConclusionsThese results demonstrated a novel role for miR ‐139‐5p/PKM2 in GBC progression and provided potential prognostic predictors for GBC patients. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Jianan Chen,
Yan Yu,
Xiaolong Chen,
Yuting He,
Qiuyue Hu,
Hongqiang Li,
Qicai Han,
Fang Ren,
Juan Li,
Chao Li,
Jie Bao,
Zhigang Ren,
Zhenfeng Duan,
Guangying Cui,
Ranran Sun Tags: ORIGINAL ARTICLE Source Type: research
Computer ‐aided identification of a novel pyruvate kinase M2 activator compound
DiscussionThis work proves that ZINC08383544 promotes the formation of PKM2 tetramer, effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumour, and ZINC08383544 may be a novel activator of PKM2. This work may provide a good choice of drug or molecular fragments for the antitumour strategy targeting PKM2. Screening of targeted drugs by combination of virtual screening and bioactivity experiments is a rapid method for drug discovery. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Yuanyuan Li,
Minyue Bao,
Chunlan Yang,
Jiao Chen,
Shu Zhou,
Rong Sun,
Chuanfang Wu,
Xin Li,
Jinku Bao Tags: ORIGINAL ARTICLE Source Type: research
RNA ‐binding protein PUM2 suppresses osteosarcoma progression via partly and competitively binding to STARD13 3′UTR with miRNAs
ConclusionPUM2 suppresses OS progression via partly and competitively binding to STARD13 3 ′UTR with miRNAs. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Ruixi Hu,
Xiaodong Zhu,
Chao Chen,
Ruijun Xu,
Yifan Li,
Wei Xu Tags: ORIGINAL ARTICLE Source Type: research
Long noncoding RNA HOTAIR promotes renal cell carcinoma malignancy through alpha ‐2, 8‐sialyltransferase 4 by sponging microRNA‐124
ConclusionsOur results demonstrated that HOTAIR mediated RCC progression in part through miR ‐124/ST8SIA4 axis, which functioned as a new prognostic biomarker in RCC. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Yue Pan,
Yongjin Wu,
Jialei Hu,
Yujia Shan,
Jia Ma,
Huipeng Ma,
Xia Qi,
Li Jia Tags: ORIGINAL ARTICLE Source Type: research
MicroRNA ‐1258 suppresses tumour progression via GRB2/Ras/Erk pathway in non‐small‐cell lung cancer
ConclusionsOur results indicate that miR ‐1258 can suppress NSCLC progression by targeting the GRB2/Ras/Erk pathway, which may lead to different insights into potential biomarkers and novel therapeutic strategies for NSCLC patients. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Wei Jiang,
Ke Wei,
Chunfeng Pan,
Hong Li,
Jing Cao,
Xu Han,
Yu Tang,
Shichao Zhu,
Weiwei Yuan,
Yaozhou He,
Yang Xia,
Liang Chen,
Yijiang Chen Tags: ORIGINAL ARTICLE Source Type: research
New piperidine derivative DTPEP acts as dual ‐acting anti‐breast cancer agent by targeting ERα and downregulating PI3K/Akt‐PKCα leading to caspase‐dependent apoptosis
ConclusionsWe identified a new dual ‐acting anti‐breast cancer molecules as a proof of concept which is capable of targeting both ER‐positive and ER‐negative breast cancer. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: A. Arun,
M.I. Ansari,
P. Popli,
S. Jaiswal,
A.K. Mishra,
A. Dwivedi,
K. Hajela,
R. Konwar Tags: ORIGINAL ARTICLE Source Type: research
Sonic hedgehog signalling regulates the self ‐renewal and proliferation of skin‐derived precursor cells in mice
ConclusionOur results suggest that the Shh signalling pathway has an important role in the proliferation, self ‐renewal and apoptosis of mSKPs. These findings also provide a better understanding of the cellular mechanisms underlying SKP self‐renewal and apoptosis that allow more efficient expansion of SKPs. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Sangkyu Park,
Hyewon Kim,
Kichul Kim,
Sangho Roh Tags: ORIGINAL ARTICLE Source Type: research
Fabrication of magnetic nanochains linked with CTX and curcumin for dual modal imaging detection and limitation of early tumour
ConclusionsWe provided a mechanism about the effect of CTX ‐NCs‐Cur on the targeting and limiting early tumour, and these results indicated the application foreground of CTX‐NCs‐Cur in tumour diagnosis and therapy. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Yuedi Yang,
Zhongbing Huang,
Ximing Pu,
Guangfu Yin,
Lei Wang,
Fabao Gao Tags: ORIGINAL ARTICLE Source Type: research
Narciclasine induces autophagy ‐dependent apoptosis in triple‐negative breast cancer cells by regulating the AMPK‐ULK1 axis
ConclusionsOur findings suggest that narciclasine regulates the AMPK ‐ULK1 signalling axis to promote autophagy‐dependent apoptosis, demonstrating therapeutic potential against TNBC. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Chuan Cao,
Wei Huang,
Nan Zhang,
Fengbo Wu,
Ting Xu,
Xiaoli Pan,
Cheng Peng,
Bo Han Tags: ORIGINAL ARTICLE Source Type: research
Yes ‐associated protein mediates angiotensin II‐induced vascular smooth muscle cell phenotypic modulation and hypertensive vascular remodelling
ConclusionsYes ‐associated protein mediated angiotensin II‐induced VSMCs phenotypic modulation and vascular remodelling. YAP is a potential therapeutic target for HVR beyond blood pressure control. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Maohuan Lin,
Woliang Yuan,
Zizhuo Su,
Caina Lin,
Tucheng Huang,
Yangxin Chen,
Jingfeng Wang Tags: ORIGINAL ARTICLE Source Type: research
LncRNA SNHG4 promotes tumour growth by sponging miR ‐224‐3p and predicts poor survival and recurrence in human osteosarcoma
ConclusionOur findings demonstrated that LncRNA SNHG4 promoted tumour growth by sponging miR ‐224‐3p and represented a poor prognostic factor in patients with osteosarcoma. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Ruida Xu,
Fan Feng,
Xiaosheng Yu,
Zude Liu,
Lifeng Lao Tags: ORIGINAL ARTICLE Source Type: research
Bi ‐directional modulation of cellular interactions in an in vitro co‐culture model of tendon‐to‐bone interface
ConclusionsThe present work assessed both the influence of OM on cell phenotype modulation and the importance of co ‐culture models while promoting cell‐cell interactions and the exchange of soluble factors in triggering an interface‐like phenotype to potentially modulate enthesis regeneration. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: I. Calejo,
Raquel Costa ‐Almeida,
Ana Isabel Gonçalves,
Dominika Berdecka,
Rui Luis Reis,
Manuela Estima Gomes Tags: ORIGINAL ARTICLE Source Type: research
Treatment of β654‐thalassaemia by TALENs in a mouse model
ConclusionThese results suggest effective treatment of the anaemia phenotype in TALENs+/ β654 mice following deletion of the mutation site by TALENs, demonstrating a simple and straightforward strategy for gene therapy of β654‐thalassaemia in the future. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Yudan Fang,
Yan Cheng,
Dan Lu,
Xiuli Gong,
Guanheng Yang,
Zhijuan Gong,
Yiwen Zhu,
Xiao Sang,
Shuyue Fan,
Jingzhi Zhang,
Fanyi Zeng Tags: ORIGINAL ARTICLE Source Type: research
