Computer ‐aided identification of a novel pyruvate kinase M2 activator compound

DiscussionThis work proves that ZINC08383544 promotes the formation of PKM2 tetramer, effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumour, and ZINC08383544 may be a novel activator of PKM2. This work may provide a good choice of drug or molecular fragments for the antitumour strategy targeting PKM2. Screening of targeted drugs by combination of virtual screening and bioactivity experiments is a rapid method for drug discovery.

Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Yuanyuan Li, Minyue Bao, Chunlan Yang, Jiao Chen, Shu Zhou, Rong Sun, Chuanfang Wu, Xin Li, Jinku Bao Tags: ORIGINAL ARTICLE Source Type: research