Impact of Afirma gene expression classifier on cytopathology diagnosis and rate of thyroidectomy
CONCLUSIONSThe incidence of indeterminate FNA diagnoses significantly increased after Afirma became routinely available, whereas the incidence of benign diagnoses significantly decreased. These data suggest that Afirma may shift FNA interpretation toward Bethesda III/IV, in which molecular testing is used. Moreover, the institutional rates of surgery and malignancy did not appear to change, raising uncertainty regarding the benefits of molecular assay risk stratification. Afirma may produce unintended collateral effects, increasing the number of indeterminate FNA diagnoses while not affecting the institutional thyroidectom...
Source: Cancer Cytopathology - May 31, 2016 Category: Pathology Authors: Wendy L. Sacks, Shikha Bose, Zachary S. Zumsteg, Ronnie Wong, Stephen L. Shiao, Glenn D. Braunstein, Allen S. Ho Tags: Original Article Source Type: research
HPV test results provide useful risk stratification information in women with ASC‐H Pap test findings
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 31, 2016 Category: Pathology Authors: R. Marshall Austin, Chengquan Zhao Tags: Correspondence Source Type: research
Cytology as a diagnostic tool in the autopsy suite
Cytology is underused in the autopsy suite. Cytodiagnostic techniques can be used to improve autopsy quality and teaching and to limit organ removal when that is appropriate. See also pages 000‐000. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 31, 2016 Category: Pathology Authors: Vicki J. Schnadig Tags: Editorial Source Type: research
Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression in breast cancer FNA cell blocks and paired histologic specimens: A large retrospective study
CONCLUSIONSER, PR, and HER2 determination on FNA‐acquired cell block (fixed exclusively in 10% formalin) showed excellent agreement for ER and HER2 and moderate agreement for PR with the corresponding tissue block. These findings support the equivalency of ER and HER2 evaluation performed on FNA cell blocks compared with surgical tissue blocks. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 31, 2016 Category: Pathology Authors: Poonam Vohra, Benjamin Buelow, Yunn‐Yi Chen, Maria Serrano, Manjiv Singh Vohra, Anna Berry, Britt‐Marie Ljung Tags: Original Article Source Type: research
Analytical validity of a microRNA ‐based assay for diagnosing indeterminate thyroid FNA smears from routinely prepared cytology slides
CONCLUSIONSThe microRNA‐based assay was robust to various physical processing conditions and to differing sample characteristics. Given the assay's performance, robustness, and use of routinely prepared FNA slides, it has the potential to provide valuable aid for physicians in the diagnosis of thyroid nodules. Cancer Cytopathol 2016;000:000‐000. © 2016 Rosetta Genomics. Cancer Cytopathology published by Wiley Periodicals, Inc. on behalf of American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 24, 2016 Category: Pathology Authors: Hila Benjamin, Temima Schnitzer ‐Perlman, Alexander Shtabsky, Christopher J. VandenBussche, Syed Z. Ali, Zdenek Kolar, Fabio Pagni, , Dganit Bar, Eti Meiri Tags: Original Article Source Type: research
Noninvasive follicular thyroid neoplasm with papillary ‐like nuclear features (NIFTP): A changing paradigm in thyroid surgical pathology and implications for thyroid cytopathology
The change in the diagnosis of noninvasive encapsulated follicular variant papillary thyroid carcinoma to noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (ie, not carcinoma) will have significant impact on the risk of malignancy for categories according to The Bethesda System for Reporting Thyroid Cytopathology, and especially for the indeterminate categories. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 19, 2016 Category: Pathology Authors: Zubair W. Baloch, Raja R. Seethala, William C. Faquin, Mauro G. Papotti, Fulvio Basolo, Guido Fadda, Gregory W. Randolph, Steven P. Hodak, Yuri E. Nikiforov, Susan J. Mandel Tags: Commentary Source Type: research
Fine ‐needle aspiration and core needle biopsy: An update on 2 common minimally invasive tissue sampling modalities
Fine‐needle aspiration (FNA) and core needle biopsy (CNB) represent 2 of the most common minimally invasive tissue sampling modalities. Although similar in many ways, there are significant differences in the collection, processing, interpretation, and suitability for ancillary testing that exist between FNA and CNB. This review provides a brief overview of the strengths and weaknesses of FNA compared with CNB, as well as an update regarding the landscape of recently published studies that investigate the organ‐specific comparative performance metrics of FNA and CNB. A current understanding of the benefits and limitatio...
Source: Cancer Cytopathology - May 15, 2016 Category: Pathology Authors: Paul A. VanderLaan Tags: Review Article Source Type: research
Fine‐needle aspiration and core needle biopsy: An update on 2 common minimally invasive tissue sampling modalities
Fine‐needle aspiration (FNA) and core needle biopsy (CNB) represent 2 of the most common minimally invasive tissue sampling modalities. Although similar in many ways, there are significant differences in the collection, processing, interpretation, and suitability for ancillary testing that exist between FNA and CNB. This review provides a brief overview of the strengths and weaknesses of FNA compared with CNB, as well as an update regarding the landscape of recently published studies that investigate the organ‐specific comparative performance metrics of FNA and CNB. A current understanding of the benefits and limitatio...
Source: Cancer Cytopathology - May 15, 2016 Category: Pathology Authors: Paul A. VanderLaan Tags: Review Article Source Type: research
Merchants of mayhem
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 12, 2016 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research
2016 publication schedule
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 12, 2016 Category: Pathology Tags: Issue Information Source Type: research
Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 12, 2016 Category: Pathology Tags: Issue Information Source Type: research
The value of a transformation zone component in anal cytology to detect HSIL
CONCLUSIONSSignificantly more false‐negative cases lacked a TZ component compared with either true‐positive or true‐negative cases. TZ cells may be an important indicator of sample quality for anal cytology because, unlike cervical sampling, the anal canal is not visualized during cytology sampling. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 12, 2016 Category: Pathology Authors: Jennifer M. Roberts, Fengyi Jin, Julia K. Thurloe, Deborah Ekman, Marjorie K. Adams, Ross L. McDonald, Clare Biro, I. Mary Poynten, Andrew E. Grulich, Annabelle Farnsworth, Tags: Original Article Source Type: research
Quantitative phase imaging to improve the diagnostic accuracy of urine cytology
CONCLUSIONSQPI shows potential for improving the diagnostic accuracy of urine cytology, especially for indeterminate cases, and should be further evaluated as an ancillary test for urine cytology. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 12, 2016 Category: Pathology Authors: Hoa V. Pham, Liron Pantanowitz, Yang Liu Tags: Original Article Source Type: research
Diagnostic concordance of non –small cell lung carcinoma subtypes between biopsy and cytology specimens obtained during the same procedure
CONCLUSIONSSubtyping of NSCLC can be achieved in most cases (97%) by considering findings in both biopsy and cytology specimens, and concordance in subtyping between cytology and biopsy specimens can be reached in a high percentage of cases (89.2%). Cancer Cytopathol 2016;124:737–43. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 11, 2016 Category: Pathology Authors: Mojgan Ebrahimi, Manon Auger, Sungmi Jung, Richard S. Fraser Tags: Original Article Source Type: research
Morphologists overestimate the nuclear ‐to‐cytoplasmic ratio
CONCLUSIONSMorphologists tended to overestimate the N:C ratio, particularly at ratios close to TPS‐recommended cutoff values. Additional training regarding N:C ratio estimation may help pathologists to adapt to this new system. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - May 8, 2016 Category: Pathology Authors: Mingjuan L. Zhang, Alan X. Guo, Christopher J. VandenBussche Tags: Original Article Source Type: research
