Big data from small samples: Informatics of next ‐generation sequencing in cytopathology
The rapid adoption of next‐generation sequencing (NGS) in clinical molecular laboratories has redefined the practice of cytopathology. Instead of simply being used as a diagnostic tool, cytopathology has evolved into a practice providing important genomic information that guides clinical management. The recent emphasis on maximizing limited‐volume cytology samples for ancillary molecular studies, including NGS, requires cytopathologists not only to be more involved in specimen collection and processing techniques but also to be aware of downstream testing and informatics issues. For the integration of molecular informa...
Source: Cancer Cytopathology - October 31, 2016 Category: Pathology Authors: Sinchita Roy ‐Chowdhuri, Somak Roy, Sara E. Monaco, Mark J. Routbort, Liron Pantanowitz Tags: Review Article Source Type: research
Young investigator challenge: Molecular testing in noninvasive follicular thyroid neoplasm with papillary ‐like nuclear features
CONCLUSIONSThe current results indicate that NIFTP is a rare tumor if defined by strict criteria, that both the GEC and UPMC methods indicate abnormalities in NIFTP, and further independent study will be needed to better characterize the molecular and clinical characteristics of NIFTP. Cancer (Cancer Cytopathol) 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 31, 2016 Category: Pathology Authors: Xiaoyin “Sara” Jiang, Grant P. Harrison, Michael B. Datto Tags: Original Article Source Type: research
Nodular sclerosis classical Hodgkin lymphoma grade 2: A diagnostic challenge to the cytopathologists
CONCLUSIONSThe diagnostic efficacy of FNAC is much lower for grade 2 NSCHL versus grade 1 NSCHL. The search for an occasional RS cell and the identification of lacunar cells can provide a clue for the diagnosis. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 31, 2016 Category: Pathology Authors: Sudha Sharma, Pranab Dey, Suvradeep Mitra, Arvind Rajwanshi, Raje Nijhawan, Radhika Srinivasan, Nalini Gupta, Ashim Das Tags: Original Article Source Type: research
Significance of high ‐risk HPV detection in women with atypical glandular cells on Pap testing: Analysis of 1857 cases from an academic institution
CONCLUSIONSTo the authors' knowledge, the current study is the largest follow‐up study published to date regarding women with AGC cytology and HPV testing. The study data indicate that hrHPV testing is useful for predicting the risk of high‐grade cervical neoplasia in women with AGC, but has no significant value in evaluating the risk of endometrial carcinoma. The combination of cytology, hrHPV testing, and patient age can significantly aid in the appropriate management of these individuals. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 23, 2016 Category: Pathology Authors: Stell Patadji, Zaibo Li, Dinesh Pradhan, Chengquan Zhao Tags: Original Article Source Type: research
Cancer Cytopathology: 20 years of advancing the field of pancreaticobiliary cytopathology
The past 20 years in cytopathology have demonstrated tremendous growth and evolution in the cytopathology of organs located below the diaphragm, with much of the progress centering on the pancreas. Cancer Cytopathology has been at the forefront of reporting advances in the field of pancreaticobiliary cytology, especially for the diagnosis of pancreatic cysts. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 13, 2016 Category: Pathology Authors: Martha Bishop Pitman Tags: Editorial Source Type: research
2016 Cancer Cytopathology Young Investigator Challenge
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 13, 2016 Category: Pathology Authors: Celeste N. Powers Tags: A Note from the Editor Source Type: research
A painful fight
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 13, 2016 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research
2016 publication schedule
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 13, 2016 Category: Pathology Tags: Issue Information Source Type: research
Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 13, 2016 Category: Pathology Tags: Issue Information Source Type: research
“…That which we call a rose…”: A critical analysis of rapid on‐site evaluation
Rapid on‐site evaluation (ROSE) is a term used in cytology. A PubMed search demonstrates a plethora of articles regarding ROSE, much of it outside the cytology literature and written without the input of cytologists. The purpose of this commentary is to provide an overview of the current state of the literature regarding this component of cytology practice and to introduce a few suggestions that may aid in the evaluation of the usefulness of ROSE. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 30, 2016 Category: Pathology Authors: Maureen F. Zakowski Tags: Commentary Source Type: research
Cytopathologic and immunophenotypic changes in NUT midline carcinoma after targeted therapy
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 30, 2016 Category: Pathology Authors: Matthew Torre, Xiaohua Qian Tags: Correspondence Source Type: research
Cytological reporting on lung FNA and small biopsy specimens in the era of personalized medicine
Because of the advancement of personalized medicine in lung cancer, the subtyping of non–small cell lung cancer and predictive biomarker testing with fine‐needle aspiration and biopsy specimens have never been more important. The pathologist needs to efficiently handle these small specimens, report the diagnosis/subtype in a clinically relevant format, and evaluate the tissue adequacy for molecular testing. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 30, 2016 Category: Pathology Authors: Mari Mino ‐Kenudson Tags: Commentary Source Type: research
Cytologic persistence of malignant cells after transurethral resection of bladder tumors: Implications for concomitant manipulation of the urinary tract at the time of endoscopic resection
CONCLUSIONSIn patients with high‐grade disease, serial bladder washing after TURBT does not appear to clear malignant cells as detected by cytology. This theoretical oncologic risk should be weighed when considering concomitant upper tract procedures such as retrograde pyelography. Future work is needed to quantify risk. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 30, 2016 Category: Pathology Authors: Liam C. Macleod, Khanh N. Pham, S. Nicholas Agoff, Kathryn L. Dahl, Thomas R. Pritchett, John M. Corman Tags: Original Article Source Type: research
The role and value of ultrasound elastography in the evaluation of thyroid nodules
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 30, 2016 Category: Pathology Authors: Anthony E. Samir Tags: Clinician's Corner Source Type: research
Diagnostic yield of cytopathology in evaluating pericardial effusions: Clinicopathologic analysis of 419 specimens
CONCLUSIONSCytologic examination has significant diagnostic utility in the evaluation of pericardial effusions and exhibits a lower false‐negative rate compared with pericardial biopsy. Submission of pericardial biopsy alongside effusion cytology is associated with increased sensitivity for detecting malignancy and may be especially useful in the setting of low‐volume pericardial effusion. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 30, 2016 Category: Pathology Authors: Jad Saab, Rana S. Hoda, Navneet Narula, Syed A. Hoda, Brian E. Geraghty, Abu Nasar, Susan A. Alperstein, Jeffrey L. Port, Tamar Giorgadze Tags: Original Article Source Type: research
