Luminal breast cancer metastases and tumor arousal from dormancy are promoted by direct actions of estradiol and progesterone on the malignant cells
Conclusions:
We conclude that hormones promote development of multi-organ macrometastases in luminal disease. The metastases display a disturbing heterogeneity, containing newly emergent ER?PR? subpopulations that would be resistant to endocrine- and chemotherapies. Similar cells are found in luminal metastases of patients. Furthermore, lack of hormones is not protective. While no overt metastases form in ovx?d mice, luminal tumor cells can seed distant organs, where they remain dormant as micrometastases and sheltered from therapies, but arousable by hormone repletion. This has implications for breast cancer survivors or ...
Source: Breast Cancer Research - December 5, 2014 Category: Cancer & Oncology Authors: Ndiya OgbaNicole ManningBrian BliesnerS AmblerJames HaughianMauricio PintoPaul JedlickaKristiina JoensuuPäivi HeikkiläKathryn Horwitz Source Type: research
Modulation of tumor fatty acids, through overexpression or loss of Thyroid Hormone Responsive Protein Spot 14, is associated with altered growth and metastasis
Conclusions:
This study demonstrates a potential role for S14 in regulating mammary tumor growth and fatty acid synthesis in vivo. Furthermore, these results suggest that modulating the amount of medium chain fatty acids, by changing the levels of S14, has the potential to impact malignant mammary tumor phenotypes. (Source: Breast Cancer Research)
Source: Breast Cancer Research - December 4, 2014 Category: Cancer & Oncology Authors: Elizabeth WellbergMichael RudolphAndrew LewisNuria Padilla-JustPaul JedlickaSteven Anderson Source Type: research
The Triple-Negative Breast Cancer Database: an omics platform for reference, integration and analysis of triple-negative breast cancer data
No abstract (Source: Breast Cancer Research)
Source: Breast Cancer Research - December 4, 2014 Category: Cancer & Oncology Authors: Rajesh RajuAswathy PaulVivekanand AsokachandranBijesh GeorgeLekshmi RadhamonyMeena VinaykumarReshmi GirijadeviMadhavan Pillai Source Type: research
HER2 expression and efficacy of T-DM1
No abstract (Source: Breast Cancer Research)
Source: Breast Cancer Research - December 3, 2014 Category: Cancer & Oncology Authors: Filippo Montemurro Source Type: research
Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland
Conclusion:
Our findings suggest that a subset of proliferating embryonic cells subsequently becomes quiescent and contributes to the pool of long-lived mammary stem cells in the adult. eLLRCs can re-enter the cell cycle, produce both mammary lineages and self-renew. Thus, our studies have identified a putative stem/progenitor cell population of embryonic origin. Further study of these cells will contribute to an understanding of how quiescent stem cells are generated during development and how fetal exposures may alter future breast cancer risk in adults. (Source: Breast Cancer Research)
Source: Breast Cancer Research - December 3, 2014 Category: Cancer & Oncology Authors: Kata Boras-GranicPamela DannJohn Wysolmerski Source Type: research
Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis
Conclusions:
The results identify AM as a target for therapeutic intervention against bone metastases. Adrenomedullin potentiates osteolytic responses in bone to metastatic breast cancer cells. Small molecule antagonists can effectively block bone-mediated responses to tumor-secreted adrenomedullin, and such agents warrant development for testing in vivo. (Source: Breast Cancer Research)
Source: Breast Cancer Research - December 2, 2014 Category: Cancer & Oncology Authors: Valerie SiclariKhalid MohammadDouglas TomkinsHolly DavisC McKennaXianghong PengLisa WessnerMaria NiewolnaTheresa GuiseAttaya SuvannasankhaJohn Chirgwin Source Type: research
E2F4 regulatory program predicts patient survival prognosis in breast cancer
Conclusion:
We defined a prognostic signature, the E2F4 regulatory activity score, and showed it to be significantly predictive of patient outcome in breast cancer regardless of treatment status and the states of many other clinicopathological variables. It can be used in conjunction with other breast cancer classification methods such as Oncotype DX to improve clinical outcome prediction. (Source: Breast Cancer Research)
Source: Breast Cancer Research - December 2, 2014 Category: Cancer & Oncology Authors: Sari KhaleelErik AndrewsMatthew UngJames DirenzoChao Cheng Source Type: research
Evaluation of proliferation and apoptosis markers in circulating tumor cells of women with early breast cancer who are candidates for tumor dormancy
IntroductionClinical dormancy is frequently observed in breast cancer. In the present study, we aimed to characterize circulating tumor cells (CTCs) in dormancy candidates (DC) with early breast cancer in terms of proliferation and apoptosis.
Methods:
Cytospins of peripheral blood mononuclear cells (PBMCs) were obtained from DC (n =122) who were disease-free for at least five years and from metastatic patients (n =40) who relapsed more than five years after surgery. Sequential samples from eight DC (n =36) who maintained a prolonged disease-free status and from eight DC (n =27) presenting late relapse during follow-up, wer...
Source: Breast Cancer Research - November 29, 2014 Category: Cancer & Oncology Authors: Maria SpiliotakiDimitris MavroudisKyriaki KapranouHarris MarkomanolakiGalatea KallergiFilippos KoinisKostas KalbakisVassilis GeorgouliasSofia Agelaki Source Type: research
Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer
Conclusions:
Breast cancer immune cell subpopulation profiles, determined by immunohistochemistry-based computerized analysis, identify groups of patients characterized by high response (in the pre-treatment setting) and poor prognosis (in the post-treatment setting). Further understanding of the mechanisms underlying the distribution of immune cells and their changes after chemotherapy may contribute to the development of new immune-targeted therapies for breast cancer. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 29, 2014 Category: Cancer & Oncology Authors: Elena García-MartínezGinés Luengo GilAsunción Chaves BenitoEnrique González-BillalabeitiaMaría Vicente ConesaTeresa García GarcíaElisa García-GarreVicente VicenteFrancisco Ayala de la Peña Source Type: research
Bipotent mammary stem cells: now in amazing 3D
For many decades, developmental biologists and cancer researchers alike have been trying to understand the relationship between the basal and luminal cell compartments in the mouse mammary epithelium. Delineating the mammary stem and progenitor cell hierarchy will provide fundamental knowledge of how cell proliferation and differentiation are orchestrated to build, maintain and regenerate a complex mammalian tissue. Moreover, it is expected to offer insight into the cells of origin for human breast cancer. A new lineage-tracing study has fuelled the discussion as to the existence of bipotent stem cells in the basal layer o...
Source: Breast Cancer Research - November 27, 2014 Category: Cancer & Oncology Authors: Renée van Amerongen Source Type: research
The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress
Conclusions:
The data reported here implicate mitochondrial and ER stress as a component of C6?s biological activity and provide insight into non-apoptotic cell death mechanisms; targeting biological pathways that induce mitochondrial dysfunction and ER stress may offer new strategies for the development of therapeutics that are effective against chemoresistant breast cancers. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 26, 2014 Category: Cancer & Oncology Authors: Rachel VadenKeith GligorichRanjan JanaMatthew SigmanBryan Welm Source Type: research
The role of androgens in experimental rodent mammary carcinogenesis
Breast cancer is currently the most frequent, fatal cancer of women in western countries. While estrogens have a widely understood involvement in breast cancer, a significant but not yet fully understood role for androgens has also been suggested. The principal androgen, testosterone, is the obligate steroidal precursor of estradiol, but can equally be metabolized into dihydrotestosterone, a more potent, pure androgen. Both androgens exert their distinctive biological effects via the androgen receptor, which is coexpressed with estrogen receptor alpha in 80 to 90% of breast cancers. The hormonal control of breast developme...
Source: Breast Cancer Research - November 25, 2014 Category: Cancer & Oncology Authors: Jaesung ChoiBasil PsarommatisYan GaoYu ZhengDavid HandelsmanUlla Simanainen Source Type: research
Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer
Conclusions:
In this study, we have identified by array CGH and confirmed by FISH a recurrent gain in 17q25.3 significantly associated to BRCA1 mutated TNBC. Up-regulated genes in the 17q25.3 amplicon might represent potential therapeutic targets and warrant further investigation. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 22, 2014 Category: Cancer & Oncology Authors: Sébastien ToffoliIsabelle BarFadi Abdel-SaterPaul DelréePascale HilbertFrédéric CavallinFabrice MoreauWim Van CriekingeMagali Lacroix-TrikiMario CamponeAnne-Laure MartinHenri RochéJean-Pascal MachielsJavier CarrascoJean-Luc Canon Source Type: research
Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer
Conclusion:
The GATA3 dependent mechanisms may call for special considerations for proper prognosis and treatment of patients. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 20, 2014 Category: Cancer & Oncology Authors: Helit CohenRotem Ben-HamoMoriah GidoniIlana YitzhakiRenana KozolAlona ZilberbergSol Efroni Source Type: research
A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer
miR-31 is well known as an anti-metastatic microRNA (miRNA) in the context of breast cancer. However, to date the mechanism of regulation of this miRNA has yet to be elucidated. The recent publication by Viré et al. in Molecular Cell [1] demonstrates for the first time that one mechanism of regulation of miR-31 is through the putative oncogene EMSY, whose amplification in breast cancer patients correlates with reduced expression of the miRNA. This regulation is dependent on the DNA-binding transcription factor ETS-1 which recruits EMSY and the histone demethylase KDM5B to the miR-31 promoter, thus repressing its transcrip...
Source: Breast Cancer Research - November 18, 2014 Category: Cancer & Oncology Authors: Laoighse MulraneWilliam GallagherDarran O¿Connor Source Type: research
