Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer

Conclusions:
In this study, we have identified by array CGH and confirmed by FISH a recurrent gain in 17q25.3 significantly associated to BRCA1 mutated TNBC. Up-regulated genes in the 17q25.3 amplicon might represent potential therapeutic targets and warrant further investigation.

Source: Breast Cancer Research - November 22, 2014 Category: Cancer & Oncology Authors: Sébastien ToffoliIsabelle BarFadi Abdel-SaterPaul DelréePascale HilbertFrédéric CavallinFabrice MoreauWim Van CriekingeMagali Lacroix-TrikiMario CamponeAnne-Laure MartinHenri RochéJean-Pascal MachielsJavier CarrascoJean-Luc Canon Source Type: research