A migrant study of pubertal timing and tempo in British-Bangladeshi girls at varying risk for breast cancer
IntroductionEarlier menarche is related to subsequent breast cancer risk, yet international differences in the age and tempo of other pubertal milestones and their relationships with body mass index (BMI) are not firmly established in populations at differing risk for breast cancer. We compared age and tempo of adrenarche, thelarche, pubarche, and menarche in a migrant study of Bangladeshi girls to the United Kingdom (UK) and assessed whether differences by migration were explained by differences in BMI.
Methods:
Included were groups of Bangladeshi (n =168, British-Bangladeshi (n =174) and white British (n =54) girls, aged...
Source: Breast Cancer Research - November 15, 2014 Category: Cancer & Oncology Authors: Lauren HoughtonGillian CooperGillian BentleyMark BoothOsul ChowdhuryRebecca TroisiRegina ZieglerRobert HooverHormuzd Katki Source Type: research
MiR-183/-96/-182 cluster is up-regulated in most breast cancers and increases cell proliferation and migration
Conclusion:
The miR-183/-96/-182 cluster is up-regulated in most breast cancer. It functions as an oncogene in breast cancer as it increases cell proliferation and migration. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 14, 2014 Category: Cancer & Oncology Authors: Pei LiCheng ShengLingling HuangHui ZhangLihua HuangZeneng ChengQubo Zhu Source Type: research
Insulin-like growth factor-I inhibition with pasireotide decreases cell proliferation and increases apoptosis in pre-malignant lesions of the breast: a phase 1 proof of principle trial
Conclusions:
IGF-I inhibition by pasireotide, acting through the IGF-1R, was associated with decreased proliferation and increased apoptosis in pre-malignant breast lesions and one DCIS. Assuming hyperglycemia can be controlled, these data suggest that inhibiting the IGF-I pathway may prove an effective alternative for breast cancer chemoprevention.Trial registrationNCT01372644 Trial date: July 1, 2007. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 11, 2014 Category: Cancer & Oncology Authors: Baljit SinghJulia SmithDeborah AxelrodPietro AmeriHeather LevittAnn DanoffMartin LesserCristina de AngelisIrineu Illa-BochacaSara LubitzDaniel HubermanFarbod DarvishianDavid Kleinberg Source Type: research
Profiling gene promoter occupancy of Sox2 in two phenotypically distinct breast cancer cell subsets using chromatin immunoprecipitation and genome-wide promoter microarrays
Conclusions:
In conclusion, our data supports the model that the Sox2 induces differential gene expression in the two distinct cell subsets in BC, and contributes to their phenotypic differences. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 8, 2014 Category: Cancer & Oncology Authors: Karen JungPeng WangNidhi GuptaKeshav GopalFang WuXiaoxia YeAbdulraheem AlshareefGilbert BigrasTodd McMullenBassam AbdulkarimRaymond Lai Source Type: research
Is immune checkpoint modulation a potential therapeutic option in triple negative breast cancer?
No abstract. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 7, 2014 Category: Cancer & Oncology Authors: David Klinke Source Type: research
An unexpected alliance between stress responses to drive oncogenesis
This study reveals a surprising hierarchy and alliance between two stress regulators with distinct transcriptional outputs to promote an aggressive oncogenic state. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 6, 2014 Category: Cancer & Oncology Authors: Melissa KeenanChien-Kuang DingJen-Tsan Chi Source Type: research
Erratum: Dual HER2 blockade: preclinical and clinical data
No abstract. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 6, 2014 Category: Cancer & Oncology Authors: Tejal PatelBhuvanesh DaveAngel RodriguezJenny ChangEdith PerezGerardo Colon-Otero Source Type: research
Identification of chemokine receptors as potential modulators of endocrine resistance in estrogen receptor positive breast cancers
Conclusion:
These data highlight CXCR7 as a potential therapeutic target, warranting clinical investigation in endocrine resistant BC. (Source: Breast Cancer Research)
Source: Breast Cancer Research - October 31, 2014 Category: Cancer & Oncology Authors: Ricardo RibasZara GhazouiQiong GaoSunil PancholiAradhana RaniAnita DunbierMitch DowsettLesley-Ann Martin Source Type: research
ß1 and ß4 integrins: from breast development to clinical practice
Following a highly dynamic and complex dialogue between the epithelium and the surrounding microenvironment, the mammary gland develops into a branching structure during puberty, buds during pregnancy, forms intricate polar acini during lactation and, once the babies are weaned, remodels and involutes. At every stage of menstrual and pregnancy cycles, interactions between the cells and the extracellular matrix (ECM) and homotypic and heterotypic cell–cell interactions give rise to the architecture and function of the gland at that junction. These orchestrated programs would not be possible without the important role of t...
Source: Breast Cancer Research - October 30, 2014 Category: Cancer & Oncology Authors: Paola NisticòFrancesca Di ModugnoSheila SpadaMina Bissell Source Type: research
Vascular endothelial growth factor-C promotes breast cancer progression via a novel anti-oxidant mechanism that involves regulation of Superoxide dismutase 3
Conclusions:
We describe a novel mechanism by which VEGF-C contributes to metastasis, via its ability to enhance TIC associated characteristics, particularly the response to ROS. We identify Sod3 as a critical mediator of VEGF-C induced metastasis, and provide evidence that the VEGF-C-Sod3 axis plays a role in human breast cancers. (Source: Breast Cancer Research)
Source: Breast Cancer Research - October 30, 2014 Category: Cancer & Oncology Authors: Chu-An WangJ HarrellRitsuko IwanagaPaul JedlickaHeide Ford Source Type: research
Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near infrared imaging parameters and tumor pathologic criteria
Conclusions:
These initial findings indicate that combining widely used tumor pathologic variables with hemoglobin parameters determined by US-NIR, may provide a powerful tool for predicting patient pathologic response to NAC before the initiation of the treatment.Trial registrationClincalTrials.gov, NCT00908609, registered 22 May 2009. (Source: Breast Cancer Research)
Source: Breast Cancer Research - October 28, 2014 Category: Cancer & Oncology Authors: Quing ZhuLiqun WangSusan TannenbaumAndrew RicciPatricia DeFuscoPoornima Hegde Source Type: research
Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancer
In this report, we summarize the involvement of this class of enzymes in breast cancer signaling and cell regulation and illustrate the potential for additional studies to define novel targets and approaches in breast cancer therapy. (Source: Breast Cancer Research)
Source: Breast Cancer Research - October 25, 2014 Category: Cancer & Oncology Authors: Anupama PalNicholas Donato Source Type: research
Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway
IntroductionObesity is a known risk factor for breast cancer. Sphingosine kinase 1 (SK1) is an oncogenic lipid kinase that is overexpressed in breast tumours and linked with poor prognosis, however, its role in obesity-driven breast cancer was never elucidated.
Methods:
Human primary and secondary breast cancer tissues were analysed for SK1 and leptin receptor expression using quantitative real-time polymerase chain reaction (qRT-PCR) assay. Leptin-induced signalling was analysed in human oestrogen receptor (ER)-positive and negative breast cancer cells using Western blotting, qRT-PCR and radiolabelling assays.
Results:
Ou...
Source: Breast Cancer Research - October 25, 2014 Category: Cancer & Oncology Authors: Heba AlshakerJonathan KrellAdam FramptonJonathan WaxmanOleg BlyussAlexey ZaikinMathias WinklerJustin StebbingErnesto YagüeDmitri Pchejetski Source Type: research
Transducin (ß)-like 1 X-linked receptor 1 promotes proliferation and tumorigenicity in human breast cancer via activation of beta-catenin signaling
IntroductionTransducin (?)-like 1 X-linked receptor 1(TBLR1) is an F-box-like and WD repeat-containing protein which functions as a switch in transcriptional activation, However, the clinical significance and biological role of TBLR1 in breast cancer remains largely unknown.
Methods:
Western blotting, immunocytochemistry and real-time PCR were used to evaluate TBLR1 expression in normal breast epithelial cells and breast cancer cell lines, clinical tissue samples and adjacent nontumor tissues, and in 214 paraffin-embedded specimens. Statistical analyses were used to test for the prognostic and diagnostic associations. The ...
Source: Breast Cancer Research - October 24, 2014 Category: Cancer & Oncology Authors: Xinghua LiWeijiang LiangJunling LiuChuyong LinShu WuLibing SongZhongyu Yuan Source Type: research
New concepts in breast cancer genomics and genetics
Massively parallel DNA and RNA sequencing approaches have generated data on thousands of breast cancer genomes. In this review, we consider progress largely from the perspective of new concepts and hypotheses raised so far. These include challenges to the multistep model of breast carcinogenesis and the discovery of new defects in DNA repair through sequence analysis. Issues for functional genomics include the development of strategies to differentiate between mutations that are likely to drive carcinogenesis and bystander background mutations, as well as the importance of mechanistic studies that examine the role of mutat...
Source: Breast Cancer Research - October 23, 2014 Category: Cancer & Oncology Authors: Rodrigo GoncalvesWayne WarnerJingqin LuoMatthew Ellis Source Type: research
