Biology of breast cancer in young women
Breast cancer arising at a young age is relatively uncommon, particularly in the developed world. Several studies have demonstrated that younger patients often experience a more aggressive disease course and have poorer outcome compared to older women. Expression of key biomarkers, including endocrine receptors, HER2 and proliferation markers, appears to be different in younger patients and young women are more likely to harbor a genetic predisposition. Despite these differences, little research to date has focused on the biology of these tumors to refine prognosis, and potentially direct treatment strategies, which remain...
Source: Breast Cancer Research - August 27, 2014 Category: Cancer & Oncology Authors: Hatem AzimAnn Partridge Source Type: research
P2Y2 receptor activation by nucleotides released from highly metastatic breast cancer cells increases tumor growth and invasion via crosstalk with endothelial cells
Conclusion:
This study suggests that P2Y2R may play an important role in cancer metastasis via modulation of the crosstalk between cancer cells and ECs. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 26, 2014 Category: Cancer & Oncology Authors: Hana JinSo EunJong LeeSang ParkJae LeeKi ChangHye Kim Source Type: research
Relationships between computer-extracted mammographic texture pattern features and
Digitized mammographic images contain computer-extractable information of the parenchymal pattern not captured during routine radiologic interpretation, which have the potential to distinguish between BRCA1/2 mutation carriers and non-carriers. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 23, 2014 Category: Cancer & Oncology Authors: Gretchen GierachHui LiJennifer LoudMark GreeneCatherine ChowLi LanSheila PrindivilleJennifer Eng-WongPeter SoballeClaudia GiambartolomeiPhuong MaiClaudia GalboKathryn NicholsKathleen CalzoneOlufunmilayo OlopadeMitchell GailMaryellen Giger Source Type: research
uPA and PAI-1 as biomarkers in breast cancer: validated for clinical use in level-of-evidence-1 studies
Urokinase plasminogen activator (uPA) is an extracellular matrix-degrading protease involved in cancer invasion and metastasis, interacting with plasminogen activator inhibitor-1 (PAI-1), which was originally identified as a blood-derived endogenous fast-acting inhibitor of uPA. At concentrations found in tumor tissue, however, both PAI-1 and uPA promote tumor progression and metastasis. Consistent with the causative role of uPA and PAI-1 in cancer dissemination, several retrospective and prospective studies have shown that elevated levels of uPA and PAI-1 in breast tumor tissue are statistically independent and potent pre...
Source: Breast Cancer Research - August 22, 2014 Category: Cancer & Oncology Authors: Michael DuffyPatricia McGowanNadia HarbeckChristoph ThomssenManfred Schmitt Source Type: research
Risk factors for self-reported arm lymphedema among female breast cancer survivors: a prospective cohort study
This study examines the incidence of self-reported lymphedema, timing of lymphedema onset, and associations between sociodemographic, clinical and lifestyle factors and lymphedema risk across racial-ethnic groups using data from a multi-center, multi-ethnic prospective cohort study of breast cancer survivors, the Health, Eating, Activity and Lifestyle Study.
Methods:
666 women diagnosed with breast cancer staged as in situ, localized or regional disease at ages 35 to 64?years were recruited through the Surveillance, Epidemiology, and End Results registries in New Mexico (non-Hispanic white and Hispanic white), Los Angeles ...
Source: Breast Cancer Research - August 22, 2014 Category: Cancer & Oncology Authors: Kayo TogawaHuiyan MaJane Sullivan-HalleyMarian NeuhouserIkuyo ImayamaKathy BaumgartnerAshley Wilder SmithCatherine AlfanoAnne McTiernanRachel Ballard-BarbashLeslie Bernstein Source Type: research
Evaluation of functional genetic variants at 6q25.1 and risk of breast cancer in a Chinese population
Conclusions:
This study suggests that the functional variant rs9383935, located at the 3?UTR of CCDC170, may be one candidate of the causal variants at 6q25.1 that modulate risk of breast cancer. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 14, 2014 Category: Cancer & Oncology Authors: Yanru WangYisha HeZhenzhen QinYue JiangGuangfu JinHongxia MaJuncheng DaiJiaping ChenZhibin HuXiaoxiang GuanHongbing Shen Source Type: research
Modeling Luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in Luminal disease
Conclusions:
We propose that response to combination endocrine/EGFR inhibitor therapies in heterogeneous Luminal cancers may improve long-term survival in patients whose primary tumors have been preselected for appropriate biomarkers, including ER, PR, CK5 and EGFR. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 13, 2014 Category: Cancer & Oncology Authors: Aaron KnoxAllison ScalingMauricio PintoBrian BliesnerJames HaughianHany Abdel-HafizKathryn Horwitz Source Type: research
The dynamic range of circulating tumor DNA in metastatic breast cancer
Conclusions:
The dynamic range of ctDNA varies substantially in patients with metastatic breast cancer. This has important implications for the use of ctDNA as a predictive and prognostic biomarker. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 9, 2014 Category: Cancer & Oncology Authors: Maryam HeidaryMartina AuerPeter UlzEllen HeitzerEdgar PetruChristin GaschSabine RiethdorfOliver MauermannIngrid LaferGunda PristauzSigurd LaxKlaus PantelJochen GeiglMichael Speicher Source Type: research
PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors
Conclusions:
While approximately one third of TNBC patients respond to neoadjuvant/adjuvant chemotherapy, recent studies have shown that patients with androgen receptor positive (AR+) TNBC are far less likely to benefit from the current standard of care chemotherapy regimens and novel targeted approaches need to be investigated. In this study, we show that activating PIK3CA mutations are enriched in AR?+?TNBC; and, we show that the growth and viability of AR?+?TNBC cell line models is significantly reduced after treatment with PI3K inhibitors used in combination with an AR antagonist. These results provide rationale for pr...
Source: Breast Cancer Research - August 8, 2014 Category: Cancer & Oncology Authors: Brian LehmannJoshua BauerJohanna SchaferChristopher PendletonLuojia TangKimberly JohnsonXi ChenJustin BalkoHenry GómezCarlos ArteagaGordon MillsMelinda SandersJennifer Pietenpol Source Type: research
Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells
Conclusions:
Our study identifies a novel AMPK-PEA15 signaling axis in the anchorage-independent growth of both normal and cancerous mammary epithelial cells, suggesting that breast cancer cells may employ mechanisms of anoikis resistance already inherent within a subset of normal HMECs. Thus, targeting the AMPK-PEA15 axis might prevent breast cancer dissemination and metastasis. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 6, 2014 Category: Cancer & Oncology Authors: Sravanth HindupurSai BalajiMeera SaxenaShubham PandeyGopalkrishnashetty SravanNamrata HedaM KumarGeetashree MukherjeeDevaveena DeyAnnapoorni Rangarajan Source Type: research
A joint analysis of metabolomics and genetics of breast cancer
Conclusions:
The addition of metabolomic profiles to the public domain TCGA dataset provides an important new tool for discovery and hypothesis testing of the genetic regulation of tumor metabolism. Particular sets of metabolites may reveal insights into the metabolic dysregulation that underlie the heterogeneity of breast cancer. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 5, 2014 Category: Cancer & Oncology Authors: Xiaohu TangChao-Chieh LinIvan SpasojevicEdwin IversenJen-Tsan ChiJeffrey Marks Source Type: research
Physical activity and telomere length in early stage breast cancer survivors
A self-reported lack of physical activity was associated with shortened telomere length in early stage breast cancer survivors, suggesting a mechanism by which exercise can reduce cellular aging. (Source: Breast Cancer Research)
Source: Breast Cancer Research - July 31, 2014 Category: Cancer & Oncology Authors: Sheila GarlandBrad JohnsonChristina PalmerRebecca SpeckMichelle DonelsonSharon XieAngela DeMicheleJun Mao Source Type: research
Dual HER2 blockade: preclinical and clinical data
Chang, Perez, and colleagues, review recent data on different combinations of anti-human epidermal growth factor receptor (HER2) treatments, as part of the ‘recent advances in breast cancer treatment’ special series. (Source: Breast Cancer Research)
Source: Breast Cancer Research - July 31, 2014 Category: Cancer & Oncology Authors: Tejal PatelBhuvanesh DaveAngel RodriguezJenny ChangEdith PerezGerardo Colon-Otero Source Type: research
Physical activity and telomere length in early stage breast cancer survivors
A self-reported lack of physical activity was associated with shortened telomere length in early stage breast cancer survivors, suggesting a mechanism by which exercise can reduce cellular aging. (Source: Breast Cancer Research)
Source: Breast Cancer Research - July 31, 2014 Category: Cancer & Oncology Authors: Sheila GarlandBrad JohnsonChristina PalmerRebecca SpeckMichelle DonelsonSharon XieAngela DeMicheleJun Mao Source Type: research
Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer
Rots and colleagues describe aberrant DNA methylation and histone modifications as two important classes of epigenetic mutations in breast cancer and review the preclinical and clinical epigenetic-based therapies currently being explored. (Source: Breast Cancer Research)
Source: Breast Cancer Research - July 29, 2014 Category: Cancer & Oncology Authors: Fahimeh FalahiMichel van KruchtenNadine MartinetGeke HospersMarianne Rots Source Type: research
