Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells

Conclusions:
Our study identifies a novel AMPK-PEA15 signaling axis in the anchorage-independent growth of both normal and cancerous mammary epithelial cells, suggesting that breast cancer cells may employ mechanisms of anoikis resistance already inherent within a subset of normal HMECs. Thus, targeting the AMPK-PEA15 axis might prevent breast cancer dissemination and metastasis.

Source: Breast Cancer Research - August 6, 2014 Category: Cancer & Oncology Authors: Sravanth HindupurSai BalajiMeera SaxenaShubham PandeyGopalkrishnashetty SravanNamrata HedaM KumarGeetashree MukherjeeDevaveena DeyAnnapoorni Rangarajan Source Type: research