Vascular endothelial growth factor-C promotes breast cancer progression via a novel anti-oxidant mechanism that involves regulation of Superoxide dismutase 3

Conclusions: We describe a novel mechanism by which VEGF-C contributes to metastasis, via its ability to enhance TIC associated characteristics, particularly the response to ROS. We identify Sod3 as a critical mediator of VEGF-C induced metastasis, and provide evidence that the VEGF-C-Sod3 axis plays a role in human breast cancers.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research