Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland

Conclusion: Our findings suggest that a subset of proliferating embryonic cells subsequently becomes quiescent and contributes to the pool of long-lived mammary stem cells in the adult. eLLRCs can re-enter the cell cycle, produce both mammary lineages and self-renew. Thus, our studies have identified a putative stem/progenitor cell population of embryonic origin. Further study of these cells will contribute to an understanding of how quiescent stem cells are generated during development and how fetal exposures may alter future breast cancer risk in adults.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research