Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis

Conclusions: The results identify AM as a target for therapeutic intervention against bone metastases. Adrenomedullin potentiates osteolytic responses in bone to metastatic breast cancer cells. Small molecule antagonists can effectively block bone-mediated responses to tumor-secreted adrenomedullin, and such agents warrant development for testing in vivo.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research