The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate
Conclusion
These results indicate that primitive erythropoiesis occurs in adult mice to rescue critical anemia because primitive erythropoiesis does not require macrophages as stroma whereas macrophages play a pivotal role in definitive erythropoiesis even outside the medulla. The cells expressing embryonic hemoglobin in this study were similar to primitive erythrocytes, indicating the possibility that yolk sac-derived primitive erythroid cells may persist into adulthood in mice. (Source: BMC Hematology)
Source: BMC Hematology - February 11, 2016 Category: Hematology Source Type: research
Hypersplenism in liver disease and SLE revisited: current evidence supports an active rather than passive process
Discussion
Cytopenias and splenomegaly in both liver disease and systemic lupus erythematosus (SLE) poorly correlate with portal hypertension, and likely reflect an active process allocating stem cell resources in response to injury. Organ injury is repaired partly by bone-marrow-derived stem cells. Signaling would thus be needed to allocate resources between repair and routine marrow activities, hematologic and bone production. Granulocyte-colony stimulating factor (G-CSF) may play a central role: mobilizing stem cells, increasing spleen size and downregulating bone production. Serum G-CSF rises with...
Source: BMC Hematology - February 9, 2016 Category: Hematology Source Type: research
Drug-related problems and potential contributing factors in the management of deep vein thrombosis
Conclusions
The most prevalent anticoagulation drug-related problems were subtherapeutic doses, overtherapeutic doses and potential drug interactions. Institutional validated decision support tools for dosing decisions during maintenance anticoagulation therapy should be developed and used accordingly in order to prevent recurrent and hemorrhagic complications and to improve clinical outcomes. (Source: BMC Hematology)
Source: BMC Hematology - February 4, 2016 Category: Hematology Source Type: research
Effect of anti-tuberculosis drugs on hematological profiles of tuberculosis patients attending at University of Gondar Hospital, Northwest Ethiopia
Conclusion
The levels of hemoglobin, hematocrit and platelet count of the TB patients were significantly lowered after completion of the intensive phase of TB treatment. Significant variation of the RDW and PDW were also observed among treatment naïve and treatment completed patients. Hematological abnormalities resulted from TB treatment should be assessed continuously throughout the course of tuberculosis therapy. (Source: BMC Hematology)
Source: BMC Hematology - January 8, 2016 Category: Hematology Source Type: research
Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study
Conclusion
These findings reveal a novel effect of GA, which may be used to foster fetal hemoglobin production.
Trial registration
ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015. (Source: BMC Hematology)
Source: BMC Hematology - December 29, 2015 Category: Hematology Source Type: research
Bleeding complications from the direct oral anticoagulants
Conclusions
Management of DOAC bleeding is variable. Clinical trial data regarding DOAC reversal is needed to facilitate optimization and standardization of bleeding treatment algorithms. (Source: BMC Hematology)
Source: BMC Hematology - December 24, 2015 Category: Hematology Source Type: research
Decreased erythrocyte nucleoside transport and hENT1 transporter expression in glucose 6-phosphate dehydrogenase deficiency
Conclusions
Nucleoside transporter activity in human erythrocytes sustains intracellular purine nucleotide levels and assists in control of plasma adenosine levels; decreased hENT1 expression and activity in G6PD-deficiency could affect red metabolism and influence a wide spectrum of responses mediated by adenosine receptors. (Source: BMC Hematology)
Source: BMC Hematology - December 19, 2015 Category: Hematology Source Type: research
Therapeutic dilemma in the management of a patient with the clinical picture of TTP and severe B 12 deficiency
Conclusions
TTP is a rare condition with fatal consequences if left untreated. Guidelines recommend TPE even if there is uncertainty about the diagnosis of TTP. B12 deficiency is common, though not typically associated with severe hematologic abnormalities. We compare the presenting characteristics of all thirteen cases of pseudo-TTP reported in the literature with those from patients in case series of TTP to suggest a set of parameters that can help clinicians distinguish between pseudo-TTP and TTP and guide decision making regarding intervention. Evaluation of all TTP cases should include a B12, met...
Source: BMC Hematology - December 1, 2015 Category: Hematology Source Type: research
Anemia in prospective blood donors deferred by the copper sulphate technique of hemoglobin estimation
Conclusion
The study showed that a significant number of the prospective blood donors deferred for having low hemoglobin by the copper sulphate method turned out to have anemia by the standard method of diagnosis. Prevalence of anemia among apparently healthy blood donors was therefore higher than expected. Measures must therefore be taken to address this in order not to lose potential blood donors due to a correctable and preventable cause such as anemia. (Source: BMC Hematology)
Source: BMC Hematology - October 22, 2015 Category: Hematology Source Type: research
Numerical analysis of in vivo platelet consumption data from ITP patients
Conclusions
Our findings support the feasibility of using numerical analysis to quantitatively interpret in vivo platelet consumption data, to identify likely etiologies of thrombocytopenias, and to assess the utility of IPF measurements in that context. (Source: BMC Hematology)
Source: BMC Hematology - October 19, 2015 Category: Hematology Source Type: research
Prevalence and factors associated with severe anaemia amongst under-five children hospitalized at Bugando Medical Centre, Mwanza, Tanzania
Conclusion
The prevalence of anaemia among under-five children admitted at BMC was high. Iron deficiency anaemia was the most common type. Factors associated with severe anaemia were unemployment among caretakers, malaria parasitaemia and presence of sickle haemoglobin. (Source: BMC Hematology)
Source: BMC Hematology - October 12, 2015 Category: Hematology Source Type: research
Prevalence and associated risk factors of anemia among HIV infected children attending Gondar university hospital, Northwest Ethiopia: a cross sectional study
Conclusions
The majority of HIV positive children in Northwest Ethiopia have a mild type of anemia and the increase in prevalence of anemia is due to being on cotrimoxazole and eating green leafy vegetables. Therefore, early diagnosis and treatment of anemia is essential in these patients. (Source: BMC Hematology)
Source: BMC Hematology - September 24, 2015 Category: Hematology Source Type: research
Detection of coagulopathy in paediatric heart surgery [DECISION study]: study protocol
Discussion
The DECISION study will identify the most useful thromboeastometry tests of blood coagulation for the prediction of excessive bleeding in children after cardiac surgery and will inform the design of future randomised controlled trials.
Trial registration
The trail was registered as ISRCTN55439761 on 23rd April 2015. (Source: BMC Hematology)
Source: BMC Hematology - August 19, 2015 Category: Hematology Source Type: research
Case-report: EBV driven lymphoproliferative disorder associated with Ruxolitinib
Conclusions
Our report further underlines that patients treated with Ruxolitinib should be monitored closely for reactivations of opportunistic pathogens and viral infections. (Source: BMC Hematology)
Source: BMC Hematology - July 11, 2015 Category: Hematology Source Type: research
A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal-bone marrow: a simple and rapid method for the isolation of mouse central bone marrow
Conclusions
A simple, rapid and efficient method for the isolation of cBM from the femora and tibiae of mice is detailed. Harvest of tibial cBM yielded about half as many cells as from the femora, representing 6.4 % and 13 %, respectively, of the total cBM of a mouse based on our analysis and a review of the literature. HSC populations were enriched within the eBM and the yield of HSCs from the mouse and human long bones was increased notably by harvest of eBM. (Source: BMC Hematology)
Source: BMC Hematology - July 9, 2015 Category: Hematology Source Type: research
