Coagulation profile of Sudanese children with homozygous sickle cell disease and the effect of treatment with omega-3 fatty acid on the coagulation parameters
ConclusionThis study provides evidence that Sudanes patients have abnormal coagulation profile and treatment with either HU or omega-3 fatty acids might partially ameliorate SCD-associated chronic coagulopathic state. (Source: BMC Hematology)
Source: BMC Hematology - November 9, 2017 Category: Hematology Source Type: research
Prevalence and determinants of anemia among pregnant women in Ethiopia; a systematic review and meta-analysis
ConclusionsAlmost one-third of pregnant women in Ethiopia were anemic. Statistically significant association was observed between anemia during pregnancy and residence, gravidity, pregnancy interval, and malaria infection during pregnancy. Regions with higher anemia prevalence among pregnant women should be given due emphasis. The concerned body should intervene on the identified factors to reduce the high prevalence of anemia among pregnant women. (Source: BMC Hematology)
Source: BMC Hematology - October 17, 2017 Category: Hematology Source Type: research
Significantly elevated foetal haemoglobin levels in individuals with glucose 6-phosphate dehydrogenase disease and/or sickle cell trait: a cross-sectional study in Cape Coast, Ghana
ConclusionThe inheritance of G6PD defect and/or SCT significantly elevate %Hb F levels in the steady state even though haemoglobin levels are not affected. (Source: BMC Hematology)
Source: BMC Hematology - September 25, 2017 Category: Hematology Source Type: research
Comparative study of sickle cell anemia and hemoglobin SC disease: clinical characterization, laboratory biomarkers and genetic profiles
ConclusionsOur data emphasize the differences between SCA and HbSC patients based on laboratory parameters and the clinical and genetic profile of both genotypes. (Source: BMC Hematology)
Source: BMC Hematology - September 15, 2017 Category: Hematology Source Type: research
Alterations in hematologic indices during long-duration spaceflight
ConclusionsWhile susceptible to the possible influence of dehydration or plasma volume alterations, these results suggest astronauts do not develop persistent anemia during spaceflight. (Source: BMC Hematology)
Source: BMC Hematology - September 8, 2017 Category: Hematology Source Type: research
The frequency and severity of epistaxis in children with sickle cell anaemia in eastern Uganda: a case-control study
ConclusionsOur results suggest that in eastern Uganda, children with sickle cell anaemia experience epistaxis more frequently and with greater severity than children without sickle cell anaemia. Further studies are indicated to confirm this conclusion and investigate aetiology. (Source: BMC Hematology)
Source: BMC Hematology - September 7, 2017 Category: Hematology Source Type: research
An outline of anemia among adolescent girls in Bangladesh: findings from a cross-sectional study
ConclusionsHigher number of adolescent girls are still suffering from anemia in Bangladesh and non-pregnant adolescent girls contributed the most. Immediate, long term and sustainable public health intervention would require to combat the situation. (Source: BMC Hematology)
Source: BMC Hematology - August 22, 2017 Category: Hematology Source Type: research
Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan preschool children: a community-based survey
ConclusionsIn young children, whole blood ZPP and erythrocyte ZPP have added diagnostic value in detecting iron deficiency compared to haemoglobin concentration alone. A single diagnostic score based on haemoglobin concentration and whole blood ZPP can rule out iron deficiency in a substantial proportion of children screened.Trial registrationClinicalTrials.gov NCT02073149 (25 February 2014). (Source: BMC Hematology)
Source: BMC Hematology - July 27, 2017 Category: Hematology Source Type: research
Prevalence of Anaemia and Associated Risk Factors among Children in North-western Uganda: A Cross Sectional Study
ConclusionsThis study demonstrates that anaemia is more prevalent in the under-5 age. The risk factors are stunting and low maternal parity. Interventions that address nutritional deficiencies in both pre-school and school children are recommended. Malaria and helminthiasis control measures counter the risk of anaemia. Further studies are required to investigate the association between maternal parity and anaemia found in this study. (Source: BMC Hematology)
Source: BMC Hematology - July 3, 2017 Category: Hematology Source Type: research
Portal hypertension as the initial manifestation of POEMS syndrome: a case report
ConclusionThis case highlights the manifestation of portal hypertension in POEMS syndrome. Lenalidomide with or without dexamethasone is effective for portal hypertension due to POEMS syndrome, though esophageal and gastric varices seems not reversible so easily. (Source: BMC Hematology)
Source: BMC Hematology - May 11, 2017 Category: Hematology Source Type: research
Circumcision in hemophilia using low quantity of factor concentrates: experience from Dakar, Senegal
ConclusionThe study shows treatment protocol using low quantity of factor concentrates is efficient in hemophilia patients who underwent circumcision. (Source: BMC Hematology)
Source: BMC Hematology - April 24, 2017 Category: Hematology Source Type: research
Prevention practices influencing frequency of occurrence of vaso-occlusive crisis among sickle cell patients in Abeokuta South Local Government Area of Ogun State, Nigeria
ConclusionThe study reveals that majority of the participants have high frequency of crisis in a month. Drug prophylaxis rather than lifestyle factors may be more important in the prevention of vaso-occlusive crisis among sickle cell patients. (Source: BMC Hematology)
Source: BMC Hematology - April 20, 2017 Category: Hematology Source Type: research
Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study
ConclusionsIn this population of patients living with SCD, chronic complications are frequent and their QOL is consequently poor. Our results highlight the need for national guidelines for SCD control, which should include new-born screening programs and strategies to prevent chronic complications. (Source: BMC Hematology)
Source: BMC Hematology - April 20, 2017 Category: Hematology Source Type: research
Case report: primary osteonecrosis associated with thrombophilia-hypofibrinolysis and worsened by testosterone therapy
ConclusionsIdiopathic ON, often caused by thrombophilia-hypofibrinolysis, is worsened by TT, and its progression may be slowed or stopped by discontinuation of TT and, thereafter, anticoagulation. Recognition of thrombophilia-hypofibrinolysis before joint collapse facilitates anticoagulation which may stop ON, preserving joints. (Source: BMC Hematology)
Source: BMC Hematology - March 27, 2017 Category: Hematology Source Type: research
Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial
ConclusionsGA has potent anti- oxidative properties in sickle cell anemia. The anti-oxidant effect of GA may thus favorably influence the clinical condition of this and further diseases characterized by oxidative stress.Trial registrationClinicalTrials.gov Identifier:NCT02467257. Registered 3rd June 2015. Retrospective registration. (Source: BMC Hematology)
Source: BMC Hematology - March 15, 2017 Category: Hematology Source Type: research
