Diagnostic predictive value of platelet indices for discriminating hypo productive versus immune thrombocytopenia purpura in patients attending a tertiary care teaching hospital in Addis Ababa, Ethiopia
Conclusion
MPV, PDW and P-LCR help in predicting thrombocytopenic patients as having ITP or hypoproductive thrombocytopenia. If these indices are used in line with other laboratory and clinical information, they may help in delaying/ avoiding unnecessary bone marrow aspiration in ITP patients or supplement a request for bone morrow aspiration or biopsy in hypoproductive thrombocytopenic patients. (Source: BMC Hematology)
Source: BMC Hematology - June 30, 2016 Category: Hematology Source Type: research
A systematic review of using and reporting survival analyses in acute lymphoblastic leukemia literature
Conclusions
The use and reporting of survival analysis in adult ALL patients undergoing allo-SCT have significant limitations. Notably, the finding of crossing survival curves was common and none of the studies assessed for the proportional hazards assumption. We encourage authors, reviewers and editors to improve the quality of the use and reporting of survival analysis in the hematology literature. (Source: BMC Hematology)
Source: BMC Hematology - June 7, 2016 Category: Hematology Source Type: research
Challenges in achieving a target international normalized ratio for deep vein thrombosis among HIV-infected patients with tuberculosis: a case series
Conclusion
We recommend more frequent monitoring and timely dose adjustment of the INR, as well as studies on alternative strategies for the treatment of DVT in TB-HIV co-infected patients. (Source: BMC Hematology)
Source: BMC Hematology - June 3, 2016 Category: Hematology Source Type: research
Prevalence of neutropenia in children by nationality
Conclusion
The prevalence of childhood NP varied considerably by geoethnicity. Measures to prevent the inappropriate investigations of healthy children with benign neutropenia are proposed. (Source: BMC Hematology)
Source: BMC Hematology - May 20, 2016 Category: Hematology Source Type: research
The MUK five protocol: a phase II randomised, controlled, parallel group, multi-centre trial of carfilzomib, cyclophosphamide and dexamethasone (CCD) vs. cyclophosphamide, bortezomib (Velcade) and dexamethasone (CVD) for first relapse and primary refractory multiple myeloma
Discussion
The development of carfilzomib offers the opportunity to further explore the anti-tumour efficacy of proteasome inhibition and, based on the available evidence, it is important and timely to obtain data on the activity, toxicity and tolerability of this drug. In contrast to ongoing phase III trials, this phase II trial has a unique subset of participants diagnosed with multiple myeloma at first relapse or refractory to no more than 1 line of treatment and will also evaluate the utility of maintenance with carfilzomib for up to 18 months and investigate minimal residual disease status to pr...
Source: BMC Hematology - May 16, 2016 Category: Hematology Source Type: research
Generic and disease-specific quality of life among youth and young men with Hemophilia in Canada
Conclusion
Despite having hemophilia, the youth in this cohort have minimal joint disease and good HRQoL. The young adults demonstrated more joint disease and slightly worse HRQoL in the domains of physical functioning and pain. The data presented here provide new information to inform the selection of Health Related Quality of Life (HRQoL) instruments for use in future clinical trials involving persons with hemophilia.
Trial registration
ClinicalTrials.gov : NCT01034904. Study funded by CSL Behring Canada. (Source: BMC Hematology)
Source: BMC Hematology - May 4, 2016 Category: Hematology Source Type: research
Design and rationale of the QUAZAR Lower-Risk MDS (AZA-MDS-003) trial: a randomized phase 3 study of CC-486 (oral azacitidine) plus best supportive care vs placebo plus best supportive care in patients with IPSS lower-risk myelodysplastic syndromes and poor prognosis due to red blood cell transfusion–dependent anemia and thrombocytopenia
Conclusions
This study will provide data on the efficacy and safety of CC-486 in the treatment of IPSS lower-risk MDS with poor prognosis due to the presence of both RBC transfusion–dependent anemia and thrombocytopenia. Positive results of the AZA-MDS-003 study may expand treatment options for patients with IPSS lower-risk MDS.
Trial registration
ClinicalTrials.gov NCT01566695, registered March 27, 2012. (Source: BMC Hematology)
Source: BMC Hematology - May 2, 2016 Category: Hematology Source Type: research
Kinetics of Langerhans cell chimerism in the skin of dogs following 2 Gy TBI allogeneic hematopoietic stem cell transplantation
Conclusion < /h3 > < p class= " a-plus-plus " > Our study indicates that LC donor chimerism correlates with chimerism development in the peripheral blood but occurs delayed following NM-HSCT. < /p > < /span > (Source: BMC Hematology)
Source: BMC Hematology - April 26, 2016 Category: Hematology Source Type: research
Kinetics of Langerhans cell chimerism in the skin of dogs following 2 Gy TBI allogeneic hematopoietic stem cell transplantation
Conclusion
Our study indicates that LC donor chimerism correlates with chimerism development in the peripheral blood but occurs delayed following NM-HSCT. (Source: BMC Hematology)
Source: BMC Hematology - April 26, 2016 Category: Hematology Source Type: research
Characteristics of chronic lymphocytic leukemia in Senegal
Conclusion
Africans may present with CLL at a younger age and our data suggest that CLL in Senegal may be more aggressive than in Western populations. (Source: BMC Hematology)
Source: BMC Hematology - April 22, 2016 Category: Hematology Source Type: research
Endothelial fibrinolytic response onto an evolving matrix of fibrin
Conclusions
HMEC-1 cells influence fibrin formation and dissolution as a function of the fibrin content of clots. Clot degradation was accentuated at high fibrin concentrations. The secretion of fibrinolytic components by HMEC-1 cells seemed to be modulated by integrins that bind RGD ligands. (Source: BMC Hematology)
Source: BMC Hematology - April 13, 2016 Category: Hematology Source Type: research
A case of multiple myeloma presenting as a distal renal tubular acidosis with extensive bilateral nephrolithiasis
Conclusion
Isolated distal renal tubular acidosis is a rare presentation of multiple myeloma. In the absence of hypercalciuria and demonstrable light chain excretion in urine, we assumed that the distal renal tubular acidosis could have been caused by monoclonal hypergammaglobulinaemic state of multiple myeloma. (Source: BMC Hematology)
Source: BMC Hematology - March 17, 2016 Category: Hematology Source Type: research
Randomized double-blind safety comparison of intravenous iron dextran versus iron sucrose in an adult non-hemodialysis outpatient population: A feasibility study
Conclusion
In this limited feasibility study, no major differences in immediate reactions were seen, but a significantly higher number of delayed reactions were seen in the iron sucrose group. Further, under our assumptions and design a full RCT to evaluate the safety of different intravenous iron preparations is not feasible. Future studies should consider modifying the clinical outcomes, utilize multiple centers, and consider other emerging parenteral iron formulations. (ClinicalTrials.gov NCT005936197 January 3, 2008). (Source: BMC Hematology)
Source: BMC Hematology - March 11, 2016 Category: Hematology Source Type: research
Hospitalization for pulmonary embolism associated with antecedent testosterone or estrogen therapy in patients found to have familial and acquired thrombophilia
Conclusions
Of 154 men hospitalized for PE, 8 (5 %) used TT, and of 193 women, 24 (12 %) used ET. Our data suggests that PE is an important complication of TT in men and ET in women, in part reflecting an interaction between familial and acquired thrombophilia and exogenous hormone use. (Source: BMC Hematology)
Source: BMC Hematology - March 8, 2016 Category: Hematology Source Type: research
BMC Hematology reviewer acknowledgement 2015
Contributing reviewers
The editors of BMC Hematology would like to thank all our reviewers who have contributed to the journal in Volume 15 (2015). (Source: BMC Hematology)
Source: BMC Hematology - February 22, 2016 Category: Hematology Source Type: research
