Blood factory: which stem cells?
AbstractBlood transfusions are often essential for treatment of severe anaemia and pregnancy complications. The unavailability of blood is a medical concern, especially in developing countries. New sources of red blood cells (RBC) are under investigation. Several studies have attempted to produce functional RBC from CD34+ haematopoietic stem cells (HSC) isolated from peripheral blood and umbilical cord blood, from embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). A recent article published in Nature Communications describes a novel model for generating RBC from a stable erythroid cell line obtained from...
Source: BMC Hematology - May 10, 2018 Category: Hematology Source Type: research
Prevalence of thrombocytopenia before and after initiation of HAART among HIV infected patients at black lion specialized hospital, Addis Ababa, Ethiopia: a cross sectional study
ConclusionsThis study has shown that the prevalence of thrombocytopenia after HAART initiation was decreased significantly. Based on our results, a number of study participants still had thrombocytopenia after initiation of HAART. Therefore, continuous screening for thrombocytopenia among HIV infected patients should be performed to decrease the risk of morbidity and mortality. (Source: BMC Hematology)
Source: BMC Hematology - May 9, 2018 Category: Hematology Source Type: research
Prevalence of cytopenias in both HAART and HAART na ïve HIV infected adult patients in Ethiopia: a cross sectional study
ConclusionHematologic abnormalities were common in HIV infected adult patients. Of the cytopenias anemia was the most common. Use of CPT was independently associated with increased risk of anemia and leucopenia. Therefore, large scale and longitudinal studies, giving emphasis on the association of CPT and cytopenia, are recommended to strengthen and explore the problem in depth. (Source: BMC Hematology)
Source: BMC Hematology - April 5, 2018 Category: Hematology Source Type: research
Prevalence of anemia before and after initiation of antiretroviral therapy among HIV infected patients at Black Lion Specialized Hospital, Addis Ababa, Ethiopia: a cross sectional study
ConclusionsIt is evident from this study that there is a remarkable reduction in the prevalence of anemia after ART initiation. However, a significant proportion of HIV patients remained anemic after 6 months of ART initiation suggesting the need for routine screening and proper treatment of anemia to mitigate its adverse effects. (Source: BMC Hematology)
Source: BMC Hematology - March 15, 2018 Category: Hematology Source Type: research
A pilot study on the usefulness of peripheral blood flow cytometry for the diagnosis of lower risk myelodysplastic syndromes: the “MDS thermometer”
ConclusionsPeripheral blood neutrophil and monocyte immunophenotyping provide useful information for the diagnosis of LR-MDS, as a complement to cytomorphology. If validated by subsequent studies in larger series of MDS patients and extended to non-MDS patients with cytopenias, our findings may improve the diagnostic assessment and avoid invasive procedures in selected groups of MDS patients. (Source: BMC Hematology)
Source: BMC Hematology - March 13, 2018 Category: Hematology Source Type: research
A rare case of avascular necrosis in sickle cell trait: a case report
ConclusionThere have only been scarce reports of avascular necrosis in patients with sickle cell trait. This manuscript presents such a case and includes the trials and tribulations associated with its management. (Source: BMC Hematology)
Source: BMC Hematology - February 22, 2018 Category: Hematology Source Type: research
More is less, less is more, or does it really matter? The curious case of impact of azacitidine administration schedules on outcomes in patients with myelodysplastic syndromes
AbstractMyelodysplastic syndromes (MDS) encompass a diverse group of hematologic disorders characterized by ineffective and malignant hematopoiesis, peripheral cytopenias and significantly increased risk of progression to acute myeloid leukemia (AML). The hypomethylating agents (HMA) azacitidine and decitabine induce meaningful clinical responses in a significant subset of patients with MDS. Though never compared directly with decitabine, only azacitidine has improved overall survival (OS) compared to conventional care in a randomized trial in patients with higher-risk MDS. The azacitidine regimen used in this pivotal tria...
Source: BMC Hematology - February 1, 2018 Category: Hematology Source Type: research
Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia
ConclusionsIndirect comparison of alternative azacitidine dosing regimens in MDS and AML shows a benefit for the 7-day regimen in attaining ORR. Additional RCTs are required to definitively address this comparison. (Source: BMC Hematology)
Source: BMC Hematology - January 31, 2018 Category: Hematology Source Type: research
Factor V Leiden G1691A and prothrombin G20210A mutations among Palestinian patients with sickle cell disease
ConclusionsFVL was more prevalent among SS patients compared to controls and it was associated with higher incidence of disease complications among SCD patients. (Source: BMC Hematology)
Source: BMC Hematology - January 16, 2018 Category: Hematology Source Type: research
Pregnant mothers are more anemic than lactating mothers, a comparative cross-sectional study, Bahir Dar, Ethiopia
ConclusionThe burden of anemia was higher in pregnant women than lactating women. (Source: BMC Hematology)
Source: BMC Hematology - January 16, 2018 Category: Hematology Source Type: research
A novel fibrinogen mutation: FGA g. 3057 C & gt; T (p. Arg104 & gt; Cys) impairs fibrinogen secretion
ConclusionsThe low expression of the A α Arg104 > Cys chain in circulation could account for the observed hypodysfibrinogenemia. (Source: BMC Hematology)
Source: BMC Hematology - December 22, 2017 Category: Hematology Source Type: research
A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia
ConclusionHypertension has impact on hematological parameters. In this study, the mean and median values of haematological parameters in hypertensive individuals were significantly different compared to apparently healthy normotensive individuals. Hence, hematological parameters can be used to monitor the prognosis of the disease and manage hypertensive related complications, and it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated hematological disorders. (Source: BMC Hematology)
Source: BMC Hematology - November 28, 2017 Category: Hematology Source Type: research
Knowledge, attitude and practice of students towards blood donation in Arsi university and Adama science and technology university: a comparative cross sectional study
ConclusionSignificant knowledge difference and attitude difference were observed between students from Arsi University and Adama Science and Technology University. (Source: BMC Hematology)
Source: BMC Hematology - November 21, 2017 Category: Hematology Source Type: research
Emergency blood transfusion practices among anaemic children presenting to an urban emergency department of a tertiary hospital in Tanzania
ConclusionThe burden of anaemia is high among children under 5 presenting to EMD-MNH. Less than a quarter of children with indications for transfusion receive it in the EMD, the median time to transfusion is nearly 8 h, and those not transfused have nearly a 3-fold higher mortality. Future quality improvement and research efforts should focus on eliminating barriers to timely blood transfusion. (Source: BMC Hematology)
Source: BMC Hematology - November 10, 2017 Category: Hematology Source Type: research
