Use of Valacyclovir for the treatment of cytomegalovirus antigenemia after hematopoietic stem cell transplantation
Conclusion
High dose Valacyclovir is a potential alternative to Valganciclovir and Foscarnet in the stable post-HSCT patient who has cytopenia and is not keen for inpatient treatment of CMV antigenemia. (Source: BMC Hematology)
Source: BMC Hematology - June 19, 2015 Category: Hematology Source Type: research
An unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome
Conclusion
To our knowledge, this is the first reported case of venous thromboembolism in pregnancy associated with heterotaxy syndrome. A discussion on pathophysiology of venous thromboembolism in pregnancy and heterotaxy syndrome has been undertaken along with treatment approach in such situations. (Source: BMC Hematology)
Source: BMC Hematology - May 12, 2015 Category: Hematology Source Type: research
Prevalence and correlates of anemia among HIV infected patients on highly active anti-retroviral therapy at Zewditu Memorial Hospital, Ethiopia
Conclusions
Although a remarkable reduction in the prevalence of anemia was observed following initiation of HAART, a significant proportion of HIV patients remained anemic after 12 months of HAART suggesting the need for routine screening and proper treatment of anemia to mitigate its adverse effects. (Source: BMC Hematology)
Source: BMC Hematology - April 30, 2015 Category: Hematology Source Type: research
BMC Hematology reviewer acknowledgement 2014
Contributing reviewers
The editors of BMC Hematology would like to thank all our reviewers who have contributed to the journal in Volume 14 (2014). (Source: BMC Hematology)
Source: BMC Hematology - February 25, 2015 Category: Hematology Source Type: research
Prophylaxis in older Canadian adults with hemophilia A: lessons and more questions
Conclusion
A significant number of older adults use secondary/tertiary continuous prophylaxis in Canada, accounting for a significant fraction of factor concentrate utilization. (Source: BMC Hematology)
Source: BMC Hematology - February 14, 2015 Category: Hematology Source Type: research
Case report: paroxysmal cold hemoglobinuria presenting during pregnancy
Conclusion
This patient had a classic presentation of paroxysmal cold hemoglobinuria with rapid onset of hemolytic anemia that resolved spontaneously. To our knowledge, this is the first report of paroxysmal cold hemoglobinuria presenting during pregnancy. (Source: BMC Hematology)
Source: BMC Hematology - February 13, 2015 Category: Hematology Source Type: research
Severe congenital neutropenia caused by the ELANE gene mutation in a Vietnamese boy with misdiagnosis of tuberculosis and autoimmune neutropenia: a case report
Conclusion
The missed and delayed diagnosis may be attributable to insufficient awareness of this rare disease on the background of frequent infections even in the immunocompetent pediatric population in Vietnam. Our results indicate further evidence for the role of ELANE in SCN. (Source: BMC Hematology)
Source: BMC Hematology - January 24, 2015 Category: Hematology Source Type: research
The IL-10 polarized cytokine pattern in innate and adaptive immunity cells contribute to the development of FVIII inhibitors
Conclusions
The global cytokine profiles of innate and adaptive immune cells showed an anti-inflammatory/regulatory pattern in HAα-FVIII(+) patients and a mixed pattern, with a bias toward inflammatory cytokine profile, in HAα-FVIII(−) patients. The occurrence of these profiles seems to be associated with presence FVIII inhibitors. (Source: BMC Hematology)
Source: BMC Hematology - January 16, 2015 Category: Hematology Source Type: research
Thrombosis as a complication of central venous access in pediatric patients with malignancies: a 5-year single-center experience
Conclusions
We conclude that pediatric surgeons and oncologists should pay close attention to ensuring optimal and accurate CVC placement, as this appears the most effective tool to minimize CVC-associated complications. (Source: BMC Hematology)
Source: BMC Hematology - October 1, 2014 Category: Hematology Source Type: research
Mast cell leukemia associated with undefined morphology and chronic basophilic leukemia
Conclusion
Elevations in CRP and IL-6 levels occurring with increases in basophil counts to high levels revealed that febrile episodes with abdominal pain seen in our patient were induced by increase in IL-6 levels released from neoplastic basophils. Neoplastic basophils with diffuse and coarse basophilic granules possibly mimic neutrophils with toxic granules and cause wrong characterization of neoplastic basophils as neutrophils by the automated blood cell counters and misleaded physicians. (Source: BMC Hematology)
Source: BMC Hematology - September 13, 2014 Category: Hematology Source Type: research
A case of congenital TTP presenting with microganiopathy in adulthood
Conclusion
Congenital TTP is a rare condition, and the above case is atypical as the patient did not present with clear evidence of microangiopathy until adulthood. Although this a rare condition it is important for physicians to be aware of as it, especially the possibility of atypical presentations, as the condition is potentially fatal and effective treatment exists. (Source: BMC Hematology)
Source: BMC Hematology - September 12, 2014 Category: Hematology Source Type: research
Profile of blood cell abnormalities among antiretroviral therapy naïve HIV patients attending the Yaounde University Teaching Hospital, Cameroon
Conclusion
In the HIV infection, peripheral blood cell abnormalities affect all cell lineages, with anaemia being the most frequent single blood cell abnormality. Blood cytopenias mainly occur in advanced immunosuppression and clinical stages. Although all HIV patients may have blood cell disorders, those with advanced disease are more prone to develop them. (Source: BMC Hematology)
Source: BMC Hematology - September 8, 2014 Category: Hematology Source Type: research
Impact of clinical factors and allograft leukocyte content on post-transplant lymphopenia, monocytopenia, and survival in patients undergoing allogeneic peripheral blood haematopoietic cell transplant
Conclusions
This study suggests that graft cell count does not influence post-transplant monocyte and lymphocyte recovery following T-cell replete allogeneic peripheral blood HCT. Post-transplant complications such as acute GVHD and/or CMV viraemia negatively influenced monocyte and lymphocyte recovery, and hence the survival. Further studies aimed at understanding the mechanisms behind sustained lymphopenia and monocytopenia post-transplant are needed. (Source: BMC Hematology)
Source: BMC Hematology - September 1, 2014 Category: Hematology Source Type: research
Anemia and associated factors among school-age children in Filtu Town, Somali region, Southeast Ethiopia
Conclusion
Anemia is a moderate public health problem in school-age children for the study area. Interventions targeting nutritional deficiencies and parasitic infections are recommended. (Source: BMC Hematology)
Source: BMC Hematology - August 18, 2014 Category: Hematology Source Type: research
Vitamin D levels are low in adult patients with sickle cell disease in Jamaica and West Africa
Conclusions
Low 25(OH)D levels in tropical Africa where the burden of sickle cell disease is highest, deserve further investigation, and a randomized trial is warranted to address efficacy of supplementation. (Source: BMC Hematology)
Source: BMC Hematology - August 16, 2014 Category: Hematology Source Type: research
