Molecular characterization of protein kinase C delta (PKC δ)-Smac interactions
Protein kinase C δ (PKCδ) is known to be an important regulator of apoptosis, having mainly pro- but also anti-apoptotic effects depending on context. In a previous study, we found that PKCδ interacts with the... (Source: BMC Biochemistry)
Source: BMC Biochemistry - May 23, 2016 Category: Biochemistry Authors: Christian Holmgren, Louise Cornmark, Gry Kalstad L ønne, Katarzyna Chmielarska Masoumi and Christer Larsson Source Type: research
Molecular characterization of protein kinase C delta (PKCδ)-Smac interactions
Protein kinase C δ (PKCδ) is known to be an important regulator of apoptosis, having mainly pro- but also anti-apoptotic effects depending on context. In a previous study, we found that PKCδ interacts with the... (Source: BMC Biochemistry)
Source: BMC Biochemistry - May 23, 2016 Category: Biochemistry Authors: Christian Holmgren, Louise Cornmark, Gry Kalstad Lønne, Katarzyna Chmielarska Masoumi and Christer Larsson Source Type: research
Identification and characterization of the novel nuclease activity of human phospholipid scramblase 1
Human phospholipid scramblase 1 (hPLSCR1) was initially identified as a Ca2+ dependent phospholipid translocator involved in disrupting membrane asymmetry. Recent reports revealed that hPLSCR1 acts as a multifunc... (Source: BMC Biochemistry)
Source: BMC Biochemistry - May 20, 2016 Category: Biochemistry Authors: Ulaganathan Sivagnanam, Shweta Narayana Murthy and Sathyanarayana N. Gummadi Source Type: research
Tubulin is a molecular target of the Wnt-activating chemical probe
In drug discovery research, cell-based phenotypic screening is an essential method for obtaining potential drug candidates. Revealing the mechanism of action is a key step on the path to drug discovery. Howeve... (Source: BMC Biochemistry)
Source: BMC Biochemistry - May 20, 2016 Category: Biochemistry Authors: Yasunori Fukuda, Osamu Sano, Kenichi Kazetani, Koji Yamamoto, Hidehisa Iwata and Junji Matsui Source Type: research
Altered activity patterns of transcription factors induced by endoplasmic reticulum stress
The endoplasmic-reticulum (ER) responds to the burden of unfolded proteins in its lumen by activating intracellular signal transduction pathways, also known as the unfolded protein response (UPR). Many signal ... (Source: BMC Biochemistry)
Source: BMC Biochemistry - March 24, 2016 Category: Biochemistry Authors: Sheena Jiang, Eric Zhang, Rachel Zhang and Xianqiang Li Source Type: research
Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity
Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA meth... (Source: BMC Biochemistry)
Source: BMC Biochemistry - March 22, 2016 Category: Biochemistry Authors: Olga V. Lukashevich, Natalia A. Cherepanova, Renata Z. Jurkovska, Albert Jeltsch and Elizaveta S. Gromova Source Type: research
Linalool isomerase, a membrane-anchored enzyme in the anaerobic monoterpene degradation in Thauera linaloolentis 47Lol
Thauera linaloolentis 47Lol uses the tertiary monoterpene alcohol (R,S)-linalool as sole carbon and energy source under denitrifying conditions. The conversion of linalool to geraniol ... (Source: BMC Biochemistry)
Source: BMC Biochemistry - March 15, 2016 Category: Biochemistry Authors: Robert Marmulla, Barbara Šafarić, Stephanie Markert, Thomas Schweder and Jens Harder Source Type: research
1,2-Dichlorobenzene affects the formation of the phosphoenzyme stage during the catalytic cycle of the Ca2+-ATPase from sarcoplasmic reticulum
1,2-Dichlorobenzene (1,2-DCB) is a benzene-derived molecule with two Cl atoms that is commonly utilized in the synthesis of pesticides. 1,2-DCB can be absorbed by living creatures and its effects on naturally-... (Source: BMC Biochemistry)
Source: BMC Biochemistry - March 11, 2016 Category: Biochemistry Authors: Javier Vargas-Medrano, Jorge A. Sierra-Fonseca and Luis F. Plenge-Tellechea Source Type: research
Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa
Pseudomonas aeruginosa, a Gram-negative, aerobic coccobacillus bacterium is an opportunistic human pathogen and worldwide the fourth most common cause of hospital-acquired infections w... (Source: BMC Biochemistry)
Source: BMC Biochemistry - March 9, 2016 Category: Biochemistry Authors: Andreas Krämer, Jan Herzer, Joerg Overhage and Franz-Josef Meyer-Almes Source Type: research
Erratum to: Purification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus
(Source: BMC Biochemistry)
Source: BMC Biochemistry - February 19, 2016 Category: Biochemistry Authors: Manoj Saxena, Rohit Kumar Sharma, Josell Ramirez-Paz, Arthur D. Tinoco and Kai Griebenow Source Type: research
BMC Biochemistry Reviewer Acknowledgement, 2015
The editors of BMC Biochemistry would like to thank all our reviewers who have contributed their time to the journal in Volume 16 (2015). (Source: BMC Biochemistry)
Source: BMC Biochemistry - February 10, 2016 Category: Biochemistry Authors: Guangde Tu Source Type: research
Characterization of a cold-active and salt tolerant esterase identified by functional screening of Arctic metagenomic libraries
The use of metagenomics in enzyme discovery constitutes a powerful approach to access to genomes of unculturable community of microorganisms and isolate novel valuable biocatalysts for use in a wide range of b... (Source: BMC Biochemistry)
Source: BMC Biochemistry - January 19, 2016 Category: Biochemistry Authors: Concetta De Santi, Bjørn Altermark, Marcin Miroslaw Pierechod, Luca Ambrosino, Donatella de Pascale and Nils-Peder Willassen Source Type: research
A comparison of the enzymatic properties of three recombinant isoforms of thrombolytic and antibacterial protein—Destabilase-Lysozyme from medicinal leech
Destabilase-Lysozyme (mlDL) is a multifunctional i-type enzyme that has been found in the secretions from the salivary glands of medicinal leeches. mlDL has been shown to exhibit isopeptidase, muramidase and a... (Source: BMC Biochemistry)
Source: BMC Biochemistry - November 21, 2015 Category: Biochemistry Authors: Alexey S. Kurdyumov, Valentin A. Manuvera, Isolda P. Baskova and Vassili N. Lazarev Source Type: research
A comparison of the enzymatic properties of three recombinant isoforms of thrombolytic and antibacterial protein—Destabilase-Lysozyme from medicinal leech
Conclusions:
The recombinant Destabilase-Lysozyme isoforms obtained in our study may be considered potential thrombolytic agents that act through a mechanism different from that of common thrombolytics. (Source: BMC Biochemistry)
Source: BMC Biochemistry - November 21, 2015 Category: Biochemistry Authors: Alexey KurdyumovValentin ManuveraIsolda BaskovaVassili Lazarev Source Type: research
The GH5 1,4-β-mannanase from Bifidobacterium animalis subsp. lactis Bl-04 possesses a low-affinity mannan-binding module and highlights the diversity of mannanolytic enzymes
β-Mannans are abundant and diverse plant structural and storage polysaccharides. Certain human gut microbiota members including health-promoting Bifidobacterium spp. catabolize dietary mannans. Little insight is ... (Source: BMC Biochemistry)
Source: BMC Biochemistry - November 11, 2015 Category: Biochemistry Authors: Johan Morrill, Evelina Kulcinskaja, Anna Maria Sulewska, Sampo Lahtinen, Henrik Stålbrand, Birte Svensson and Maher Abou Hachem Source Type: research
