Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity

Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA meth...

Source: BMC Biochemistry - March 22, 2016 Category: Biochemistry Authors: Olga V. Lukashevich, Natalia A. Cherepanova, Renata Z. Jurkovska, Albert Jeltsch and Elizaveta S. Gromova Source Type: research