Characterization of association of human mitochondrial lysyl-tRNA synthetase with HIV-1 Pol and tRNA3Lys
An important step in human immunodeficiency virus type 1 (HIV-1) replication is the packaging of tRNA3Lys from the host cell, which plays the role of primer RNA in the process of initiation of reverse transcripti... (Source: BMC Biochemistry)
Source: BMC Biochemistry - March 21, 2018 Category: Biochemistry Authors: Fawzi Khoder-Agha, Jos é M. Dias, Martine Comisso and Marc Mirande Tags: Research article Source Type: research
Feruloyl esterase immobilization in mesoporous silica particles and characterization in hydrolysis and transesterification
Enzymes display high reactivity and selectivity under natural conditions, but may suffer from decreased efficiency in industrial applications. A strategy to address this limitation is to immobilize the enzyme.... (Source: BMC Biochemistry)
Source: BMC Biochemistry - February 2, 2018 Category: Biochemistry Authors: Cyrielle Bonzom, Laura Schild, Hanna Gustafsson and Lisbeth Olsson Tags: Research article Source Type: research
Characterization of sulfhydryl oxidase from Aspergillus tubingensis
Despite of the presence of sulfhydryl oxidases (SOXs) in the secretomes of industrially relevant organisms and their many potential applications, only few of these enzymes have been biochemically characterized... (Source: BMC Biochemistry)
Source: BMC Biochemistry - December 8, 2017 Category: Biochemistry Authors: Outi Nivala, Greta Faccio, Mikko Arvas, Perttu Permi, Johanna Buchert, Kristiina Kruus and Maija-Liisa Mattinen Tags: Research article Source Type: research
Glycyl-alanyl-histidine protects PC12 cells against hydrogen peroxide toxicity
Peptides with cytoprotective functions, including antioxidants and anti-infectives, could be useful therapeutics. Carnosine, β-alanine-histidine, is a dipeptide with anti-oxidant properties. Tripeptides of Ala... (Source: BMC Biochemistry)
Source: BMC Biochemistry - November 22, 2017 Category: Biochemistry Authors: Hideki Shimura, Ryota Tanaka, Yoshiaki Shimada, Kazuo Yamashiro, Nobutaka Hattori and Takao Urabe Tags: Research article Source Type: research
Antiproliferative factor (APF) binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4) extracellular domain
Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis —a chronic, painful bladder disease. APF inhibits the proliferation of normal bladder epithelia... (Source: BMC Biochemistry)
Source: BMC Biochemistry - September 11, 2017 Category: Biochemistry Authors: Burzin Chavda, Jun Ling, Thomas Majernick and Sonia Lobo Planey Tags: Research article Source Type: research
Use of a special Brazilian red-light emitting railroad worm Luciferase in bioassays of NEK7 protein Kinase and Creatine Kinase
Luciferases, enzymes that catalyze bioluminescent reactions in different organisms, have been extensively used for bioanalytical purposes. The most well studied bioluminescent system is that of firefly and oth... (Source: BMC Biochemistry)
Source: BMC Biochemistry - July 19, 2017 Category: Biochemistry Authors: Arina Marina Perez, Bruno Aquino, Vadim Viviani and J örg Kobarg Source Type: research
Dacin, one metalloproteinase from Deinagkistrodon acutus venom inhibiting contraction of mouse ileum muscle
Mice were bitten by five-pace vipers (Deinagkistrodon acutus), and then envenomed. It was well-known that the snake venom mainly disturbed the blood homeostasis of the envenomed victims. Ocassionally, we found th... (Source: BMC Biochemistry)
Source: BMC Biochemistry - July 12, 2017 Category: Biochemistry Authors: Bin Zhou, Gang Liu, Qiyi He, Bo Li and Xiaodong Yu Source Type: research
Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor
Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders ... (Source: BMC Biochemistry)
Source: BMC Biochemistry - May 31, 2017 Category: Biochemistry Authors: Robert D. Bongard, Michael Lepley, Khushabu Thakur, Marat R. Talipov, Jaladhi Nayak, Rachel A. Jones Lipinski, Chris Bohl, Noreena Sweeney, Ramani Ramchandran, Rajendra Rathore and Daniel S. Sem Source Type: research
Chemical and structural characterization of α-N-acetylgalactosaminidase I and II from starfish, asterina amurensis
The marine invertebrate starfish was found to contain a novel α-N-acetylgalactosaminidase, α-GalNAcase II, which catalyzes removal of terminal α-N-acetylgalactosamine (α-GalNAc), in addition to a typical α-N-a... (Source: BMC Biochemistry)
Source: BMC Biochemistry - May 25, 2017 Category: Biochemistry Authors: Md. Harun-Or Rashid, Golam Sadik, AHM Khurshid Alam and Toshihisa Tanaka Source Type: research
Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem
The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of β-lactams, carbapenems bind to and inhibit non-classical tran... (Source: BMC Biochemistry)
Source: BMC Biochemistry - May 25, 2017 Category: Biochemistry Authors: Mario A. Bianchet, Ying H. Pan, Leighanne A. Brammer Basta, Harry Saavedra, Evan P. Lloyd, Pankaj Kumar, Rohini Mattoo, Craig A. Townsend and Gyanu Lamichhane Source Type: research
Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase
Eukaryotic tRNA splicing is an essential process in the transformation of a primary tRNA transcript into a mature functional tRNA molecule. 5 ′-phosphate ligation involves two steps: a healing reaction catalyze... (Source: BMC Biochemistry)
Source: BMC Biochemistry - May 16, 2017 Category: Biochemistry Authors: Gopinath Muruganandam, Arne Raasakka, Matti Myllykoski, Inari Kursula and Petri Kursula Source Type: research
CrMAPK3 regulates the expression of iron-deficiency-responsive genes in Chlamydomonas reinhardtii
Under iron-deficient conditions, Chlamydomonas exhibits high affinity for iron absorption. Nevertheless, the response, transmission, and regulation of downstream gene expression in algae cells have not to be inve... (Source: BMC Biochemistry)
Source: BMC Biochemistry - May 16, 2017 Category: Biochemistry Authors: Xiaowen Fei, Junmei Yu, Yajun Li and Xiaodong Deng Source Type: research
Binding of smoothelin-like 1 to tropomyosin and calmodulin is mutually exclusive and regulated by phosphorylation
The smoothelin-like 1 protein (SMTNL1) can associate with tropomyosin (Tpm) and calmodulin (CaM), two proteins essential to the smooth muscle contractile process. SMTNL1 is phosphorylated at Ser301 by protein ... (Source: BMC Biochemistry)
Source: BMC Biochemistry - March 21, 2017 Category: Biochemistry Authors: Annegret Ulke-Lem ée, David Hao Sun, Hiroaki Ishida, Hans J. Vogel and Justin A. MacDonald Source Type: research
Increased enzymatic hydrolysis of sugarcane bagasse by a novel glucose- and xylose-stimulated β-glucosidase from Anoxybacillus flavithermus subsp. yunnanensis E13T
β-Glucosidase is claimed as a key enzyme in cellulose hydrolysis. The cellulosic fibers are usually entrapped with hemicelluloses containing xylose. So there is ongoing interest in searching for glucose- and x... (Source: BMC Biochemistry)
Source: BMC Biochemistry - March 16, 2017 Category: Biochemistry Authors: Yang Liu, Rui Li, Jing Wang, Xiaohan Zhang, Rong Jia, Yi Gao and Hui Peng Source Type: research
