Antifibromyalgic activity of standardized extracts of Phyllanthus amarus and Phyllanthus fraternus in acidic saline induced chronic muscle pain
Conclusion The results of the present study suggest that in the present model, muscle-mediated pain can be alleviated by standardized extracts of Phyllanthus species and suggest that these can be useful in treatment of chronic musculoskeletal pain syndromes such as fibromyalgia. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Antiosteoporotic effects of L-Arginine in ovariectomied rats
Conclusions L-Arginine (10 mg/kg) contributes significantly to the treatment of the bone loss induced by ovariectomy on rats, demonstrated by increased bone mass, improved bone structure and recovery of bone biomechanical activity. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Evaluation of anti-arthritic activity of ethyl acetate fraction of Cassia auriculata Linn. leaves
Conclusion From our study we can come to a conclusion that the quercetin and gallic acid present in EACA possess promising ant-arthritic activity by modulating bone erosion which may be attributed to its anti-inflammatory and analgesic activity. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Effects of syringic acid on chronic MPTP/probenecid induced motor dysfunction, dopaminergic markers expression and neuroinflammation in C57BL/6 mice
In this study, the neuroprotective efficacy of syringic acid (SA) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probencid (MPTP/p) induced mouse model of PD was investigated. The C57BL/6 mice were given 10 doses of MPTP/p for five consecutive weeks with 3.5day interval. Administration of MPTP/p led to reduced motor coordination, neurochemicals and tyrosine hydroxylase (TH), dopamine transporter (DAT) and vesicular monoamine transporter-2 (VMAT2) expression. In addition, increased oxidative stress markers and the expression of inflammatory markers, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) an...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Assessment of facial emotions recognition in aging and dementia. The development of a new tool
Publication date: April–June 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 2 Author(s): Cátia Carvalho , Manuela Páris , Miguel Lemos , Bruno Peixoto The recognition of emotions from facial expressions is a basic human aptitude. The aging process is related with a decrease of this ability, particularly in the recognition of negative emotions. This decrease is more prominent in the context of dementia. Despite the growing of researches on emotion recognition, there is a lack of instruments capable of identifying individual differences regarding aging and dementia. This work aims to determine...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
The biological time calendar
Publication date: April–June 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 2 Author(s): Huynh Thien Duc Time passing drives all living organismes to cellular decline with age-associated dysfuntion, diseases and death. It appeared now that ageing like any biological process is surceptible to regulation. Environmental factors such as stimuli/stresses as well as endogenous factors, i.e., expression and mutation of some particular genes might act as the main regulators. Psychological factors as a human specific dimension could contribute in delaying the senescence decline. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
A review of CXCR4/CXCL12 axis in colorectal cancer
Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): Zhi-Yu Song , Zu-Hua Gao , Xian-Jun Qu The chemokine CXCL12 (SDF-1) is an extracellular chemokine which binds to its cell surface receptor CXCR4. The axis of CXCL12/CXCR4 has been considered to play an important role for cancer cell migration. Recently, the aberrant expression of CXCR4 has been found during the malignancy of colorectal cancer (CRC), where it plays a crucial role in, among others, the proliferation, angiogenesis and metastatic spread. Various intracellular signal transduction cascades an...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Evaluation of psychopharmacological activity of ethyl acetate extract of Sarcostemaacidum (ROXB).voigt
Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): T. Rahees , Sibi P. Ittiyavirah Herbal medicines are gaining growing interest because of their cost-effective, eco-friendly attributes and true relief from disease condition. Sarcostemaacidum was documented in many folklore practices for various psychiatric conditions. It has been dealt with in detail in “SHRUSHRUTHA SAMHITHA”. Ethyl acetate extract of the whole plant Sarcostemaacidum (EASA) was evaluated for psychopharmacological effects, anti-psychotic, anxiolytic and CNS inhibitory activity. Anti-...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Ameliorating effect of Phoenix dactylifera on lambda cyhalothrin induced biochemical, hematological and hepatopathological alterations in male wistar rats
Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): Mani Ramadhas , Krishnan Palanisamy , Munisamy Sudhagar , Vinayagam Magendira Mani Lambda cyhalothrin (LTC) is a synthetic pyrethroid insecticide, widely used to control insect pests in agriculture, public health, and homes and gardens. In the present study, an attempt has been made to study the effect of lambda cyhalothrin on biochemical, hematological parameters and ameliorating effects of palm dates (Phoenix dactylifera) in male wistar rat. Adult male Wistar rats were divided into four different gro...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Modulatory effect of moringa oleifera against gamma-radiation-induced oxidative stress in rats
Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): Heba H. Mansour , Naglaa E.R. Ismael , Hafez F. Hafez The present study was carried out to investigate the antioxidant activity and the protective effects of the aqueous leaf extract of Moringa oleifera (MO) on α-radiation-induced toxicity in cardiac and pulmonary tissues in rats. Rats were administered MO (300mg/kg, oral gavage) for 15 consecutive days and 1h after the last dose, rats were exposed to 6Gy α-radiation. Irradiation toxicity was manifested biochemically by an increase in serum triglyceri...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Assisting the diagnosis of Cushing syndrome by pattern recognition methods, using a combination of eight routine tests and their multiple correlation with serum cortisol
In conclusion this efficient and versatile system is clinically very useful, and would improve patients’ QOL. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Adverse biochemical effects of various pesticides on sprayers of cotton fields in El-Behira Governorate, Egypt
Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): Moustafa A. Abbassy , Abd El-Salam Mohamed Marei , Mohamed Aatef Mohamed Al-Ashkar , Abdel-Tawab H. Mossa A total of 60 healthy pesticide sprayers (smokers and non-smokers) in cotton fields exposed to different classes of pesticides for many years were compared with controls matched for age with respect to serum cholinesterase (ChE), serum total protein, alkaline and acid phosphatases (ALP and AP), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), creatine kinase (CK), blood glucose, serum...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Effect of long intake of aspartame on ionic imbalance in immune organs of immunized wistar albino rats
This study focus is to understand whether the oral administration of aspartame (40mg/kg b.w.) for 90days, have any effect on membrane bound ATPase's, which may cause ionic disproportion and imbalance the homeostasis of immune organs in wistar albino rats. To mimic human methanol metabolism, folate deficient rats were used. After 90days of aspartame administration, showed a significant alteration in membrane bound ATPase's and serum ions. Excess free radical generation is confirmed by increase in lipid peroxidation and nitric oxide level. This study concludes that oral administration of aspartame (40mg/kg b.w.) for longer d...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Oxidant/antioxidant status in subjects with HIV infection in different clinical conditions
Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): Ivón González-Blanco , Vianka Calás-Hechavarria , Rosario Gravier-Hernández , Daniel Pérez-Correa , Angélica Reyes-Pérez , Daymé Hernández-Requejo , Mariela Guevara-García , Viviana García-Mir , Lizette Gil-del Valle , Olga Sonia León-Fernández , L Jorge Pérez-Ávila Infection by human immunodeficiency virus (HIV) causes persistent chronic inflammation with sustained reactive oxygen species generation. An increasing number of studies underline the impact of the pathogenetic role of...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Cryptophycin F – A potential cyanobacterial drug for breast cancer
Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): Muniraj Sangeetha , Muniraj Menakha , Subramaniyan Vijayakumar Cancer is a group of disease characterized by uncontrolled cell divisions leading to abnormal growth of the tissue. Worldwide, breast cancer is the second most common type of cancer after lung cancer. Estrogen and progesterone bind to the receptors and may work with growth factors to cause cancer cell growth and proliferation. Estrogen receptor alpha (ERα) is essential for mammary gland development and also plays a central role in breast ca...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
