Application of chitosan and herbal nanocomposites to develop antibacterial medical textile
Conclusion The study concludes that, nanocomposites could provide better functional properties than the bulk finished fabrics. The nano-sized particles in the composites was considered significant for its functional applications in hospital based fabrics to prevent the transmission of nosocomial infections. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Cardioprotective effects of Ficus religiosa in neonatal streptozotocin-induced diabetic cardiomyopathy in rats
Publication date: January–March 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 1 Author(s): Raman Sharma , Ashok Kumar , Bharatur Parthasarathy Srinivasan , Anisha Chauhan , Kiran Dubey Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g)...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Prediction of new cyanobacterial drug for treating lung cancer
In this study, Tiglicamide A was predicted as the best active cyanobacterial compound derived from Lyngbya confervoides. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Contraceptive activity of 4-(4-hydroxy-3-methyl-hex-5-enyl)-chroman-2,7-diol via inhibiting ovulation in Gonadotropin-primed immature rat model
Publication date: January–March 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 1 Author(s): Ashok Kumar , Sumeet Gullaiya , Vishal Dubey , Ashish Nagar , Varun Singh , Shyam S. Agrawal Gonadotropin-primed immature rats (GPIR) were used to study the anti-ovulatory effect of 4-(4-hydroxy-3-methyl-hex-5-enyl)-chroman-2,7-diol (chroman derivative) isolated from seeds of Ensete superbum on ovulation. Present results depicted dose-related anti-ovulatory effect of the chroman derivative at 2mg/kg bw and 4mg/kg bw. Chroman derivative showed dose-dependent anti-estrogenic activity on MCF-7 cell line....
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Protective activity profile of herbomineral medicine in early diabetic nephropathy rats: Restoration of kidney antioxidants, hemodynamics and suppression of proinflammatory mediators
Publication date: January–March 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 1 Author(s): Suresh Ramnath Naik , Nazneen Shaikh , Rajesh R. Patil , Rahul S. Somani , Abhijit S. Mali The effect of Shakrino, a herbomineral medicine (HMM)) on early diabetic nephropathy in rats was evaluated. The occurrence of early diabetic nephropathy (DN) in rats treated with streptozotocin was revealed by hyperglycemia, depleted liver glycogen, decreased glucose uptake by peripheral tissue, impaired renal function, increased lipid peroxidation and decreased antioxidants in kidney. These changes were associat...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Anticonvulsant activity of Morusin isolated from Morus alba: Modulation of GABA receptor
Conclusion The findings of current study provide pharmacological credibility to anticonvulsant activity of Morusin. The protection against the convulsions and restoration of GABA level give a suggestion to its probable mechanism of action. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Protective effect of umbelliferone on high-fructose diet-induced insulin resistance and oxidative stress in rats
Publication date: January–March 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 1 Author(s): Ramasamy Chandramohan , Leelavinothan Pari The present study was designed to investigate the effect of umbelliferone (UMB) on insulin resistance (IR) and oxidative stress in rats fed a high fructose diet (HFD). Male Wistar rats received a daily diet containing either 60% fructose or 60% starch. They were administered with the UMB at three different doses (10, 20 and 40mg/kg, p.o) from the 16th day. At the end of 60 days, HFD rats exhibited significant increases in plasma glucose and insulin levels. The ac...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Hepato-ameliorative effect of hesperidin and ellagic acid on mercuric chloride intoxicated rats
Publication date: January–March 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 1 Author(s): Erusan Bharathi , Ganesan Jagadeesan , Murugan Vijayakumar Protective efficacy of Hesperidin and Ellagic acid on hepatotoxicity induced by mercuric chloride for 7 days in rats, Rattus norvegicus, were carried out in the present study. At sub-lethal dose of mercuric chloride (1.23mg/kg body weight) was administrated in rats for 7 days through oral dose. After completing the scheduled exposure time, the intoxicated rats were sacrificed and then whole liver organ was isolated immediately and they used for b...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Camel urine inhibits inflammatory angiogenesis in murine sponge implant angiogenesis model
Publication date: January–March 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 1 Author(s): Abdulqader A. Alhaider , Abdel Galil M. Abdel Gader , Nawaf Almeshal , Sarita Saraswati Camel urine has traditionally been used to treat cancer, but this practice awaits scientific scrutiny, in particular its role in tumor angiogenesis, the key step involved in tumor growth and metastasis. We aimed to investigate the effects of camel urine on key components of inflammatory angiogenesis in the murine cannulated sponge implant angiogenesis model. Polyester-polyurethane sponges, used as a framework for fib...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Pyrethroid deltamethrin-induced developmental neurodegenerative cerebral injury and ameliorating effect of dietary glycoside naringin in male wistar rats
Publication date: January–March 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 1 Author(s): Vinayagam Magendira Mani , Sivaji Asha , Abdul Majeeth Mohamed Sadiq Deltamethrin (DEL) is a type II α - cyano group containing synthetic pyrethroid insecticide that is used extensively for controlling flies, mosquitoes, insects, pests worldwide. DEL exposure leads to pathophysiology of a broad spectrum of cerebrovascular & neurodegenerative disorders like Parkinson's, Lou Gehrig's disease, Alzheimer's disease, developmental deficits, birth defects, and learning disabilities. In these studies, w...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Thyroxine-induced cardiac hypertrophy: Role of ascorbic acid in treatment
Publication date: April–June 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 2 Author(s): Ezar Hafez , Ehab Tousson The heart is a major target organ for thyroid hormone action and marked changes occur in cardiac function in the case of hypo- or hyperthyroidism. Hyperthyroidism is a common metabolic disorder with prominent cardiovascular manifestation. We studied the changes in the heart structure and functions of hyperthyroid rat and ameliorating and protective role of ascorbic acid in treatment. Fourty male albino rats were equally divided into five groups; the first and second groups were the ...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Antioxidant mediated antiulcer effect of Eupatorium triplinerve Vahl against acetic acid induced ulcerative colitis in mice
Conclusions The E. triplinerve based therapy resolved that some constituents in extract have an antiulcer effect against UC at colon specific area through its inviolable radical scavenging activity. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
In silico identification of potent inhibitors of alpha-synuclein aggregation and its in vivo evaluation using MPTP induced Parkinson mice model
This study initially investigates drug likeness and ADMET properties of CNB-001, 7,8 dihydroxyflavone, curcumin, naringenin and emodin and its inhibitory effect on alpha-synuclein (PDB: 1XQ8) aggregation via molecular docking (LeadIT). Results revealed that the ligands satisfy drug likeness and ADMET properties and best-fit ligands were associated with VAL95, GLU83 and ALA91 as major amino acid residues of receptor site. Moreover, CNB-001 showed potent inhibitory effect than other compounds with a docking score of –13.6158. Further, we investigated the inhibitory effect of CNB-001 against alpha-synuclein expression using...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Liver damage associated with exposure to aspirin and diazinon in male rats and the ameliorative effect of selenium
Conclusions The present study indicates that liver enzymes, histopathology and immunoreactivity of caspase-3 would trigger ASA- and DIA-induced liver injury. The severities of such observations were more pronounced in their combined exposure. Combination therapy with Se restored these alterations to within the normal limits and prevents disruptions of liver structures. The data throw light on the problem of simultaneous exposure to OPIs and commonly used drugs especially that are metabolised by CYP450. Accordingly, ASA should be avoided since many of the adverse effects associated with these drugs are similar to the compli...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Antiproliferative effect of coumarin by modulating oxidant/antioxidant status and inducing apoptosis in Hep2 cells
Publication date: April–June 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 2 Author(s): Sankaran Mirunalini , Krishnamoorthy Deepalakshmi , Jalagopal Manimozhi Considering the importance of plant derived compounds in prevention of cellular damage caused by reactive oxygen species which has been implicated to several diseases, this present study was undertaken to evaluate the anticancer effects of coumarin by MTT assay, lipid peroxidation markers and antioxidants status against Hep2 cancer cells. A Hep2 cells was treated with different concentrations of coumarin (2.5–1000μg/ml) for 24h and i...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
