Effect of N-acetylcysteine on γ-radiation-induced cytotoxicity in human hepatocellular carcinoma cells
This study investigated the effect of N-acetylcysteine (NAC) against γ-radiation-induced cytotoxicity in human hepatocellular carcinoma (HepG2) cells. HepG2 Cells were incubated with 20mM of NAC for 24h prior to 6Gy γ-irradiation. Apoptosis markers, such as caspase-3 and DNA fragmentation and oxidative stress markers, such as total nitrate/nitrite (NO(x)) and malondialdehyde (MDA) levels, superoxide dismutase (SOD) and glutathione (GSH) content were studied. Half of the lethal dose (LD50) of NAC on HepG2 cell viability was found to be 20mM/mL after incubation for 48h. Incubation of irradiated HepG2 cells with NAC inhibit...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Antiulcer activity of Garcinia indica fruit rind (kokum berry) in rats
In conclusion, GIE possesses potent antiulcer activity, which may be attributed to an underlying antioxidant activity. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Screening of topical gel containing lycopene and dexamethasone against UV radiation induced photoaging in mice
Publication date: October–December 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 4 Author(s): Harshit Shah , Shruti Rawal Mahajan Sun continuously emits UV radiation which produces series of pathological changes in the body, in long term, this ultimately results in photoaging and skin cancer on long term. Repeated UV exposure increases oxidative stress, nitrosative stress and inflammatory mediators which lead to activation of p38, MMPs and results in photoaging. Lycopene is an antioxidant and very low dose of dexamethasone provides anti-inflammatory effect. Animals were applied with lycopene ge...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Proposed interaction of some novel antidepressant pyrazolines against monoamine oxidase isoforms. Molecular docking studies and PASS assisted in silico approach
The objective of the current study is to identify the reason for such biological activities of the molecules by using molecular docking studies. In the molecular modeling studies, it is revealed that most of the antidepressant molecules showed good binding affinity towards MAO-A than MAO-B that is an effective target for the treatment of depression. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
The response-to-retention hypothesis: From theory to the potential therapeutic approaches
Publication date: October–December 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 4 Author(s): Livan Delgado-Roche The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein B-containing lipoproteins. Retained lipoproteins are chemically and enzymatically modified, inducing a chronic inflammatory response. Therapeutic approaches for atherosclerosis treatment have been focused on the control of risk factors, such as hypercholesterolemia, hypertension, and diabetes mellitus. Nonetheless, the efficacy of these strategies is limited and unfortunately the health prob...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
