Identification of novel cyanobacterial compounds for oral disease through in vitro and insilico approach
Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): Vijayakumar Madhumathi , Suburamaniyan Vijayakumar In this research, we have conducted docking study to screen bioactive compounds from Microcystis aeruginosa and Phormidium corium. Among the two blue-green algal species were analyzed for chemical nature of bioactive substances using TLC and GC-MS methods. The antimicrobial compounds identified were phenolics, alkaloids, steroids. In the present study as reported that M. aeruginosa curde extract contained the bioactive compound Microginins, while Cyalob...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
In vivo restoration of hepatic and nephro protective potential of hesperidin and ellagic acid against mercuric chloride intoxicated rats
Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): G. Jagadeesan , E. Bharathi The present experimental study is to investigate the efficacy of some phytochemicals on heavy metal intoxicated animals. Commonly phytochemicals have played a vital role for protective effect of oxidative stress, which is induced by heavymetals in animals. At sub-lethal dose of mercuric chloride (1.23mg/kg body weight) treated rat liver tissue shows hepatic cell damage and alteration of its metabolic activities by the way of liver marker enzymes. The hepato-protective effect o...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Anti-arthritic activity profile of methanolic extract of Ficus bengalensis: Comparison with some clinically effective drugs
Conclusion The antioxidant property of MEFB may largely be responsible for its anti-arthritic activity, and can be a feasible therapeutic candidate for the treatment of chronic arthritis. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Anti-arthritic activity of methanol extract of Cyathocline purpurea (whole plant) in Freund's complete adjuvant-induced arthritis in rats
Conclusion C. purpurea may be a potential preventive or therapeutic candidate for the treatment of inflammation and arthritis. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Antiarthritic potential of Ocimum gratissimum L. in collagen induced arthritic Sprague-Dawley rats
Conclusion EEOG can able to nullify most of the ill effects produced by CIA in rats. However, further studies are needed to carry out identification, isolation of active fractions of EEOG to unravel the mechanism of drug. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Novel thalidomide analogs: Anti-angiogenic and apoptotic effects on Hep-G2 and MCF-7 cancer cell lines
In conclusion, this study showed that thalidomide analogs are more potent anti-tumor agents with more pronounced effect by working selectively on specific types of tumors than thalidomide. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Treatment of muscle invasive urinary bladders tumors: A potential role of the mTOR inhibitors
In this study, we evaluated different schedules of gemcitabine and cisplatin to determine the efficacy of this combination together with two mammalian targets of rapamycin (mTOR) inhibitors: temsirolimus and everolimus. The 5637, HT1376 and T24 urinary bladder cancer cell lines were exposed to gemcitabine (72hours), cisplatin (48hours), temsirolimus (72hours) and everolimus (72hours), in isolation, or in combined schedules (gemcitabine, cisplatin and temsirolimus, or gemcitabine, cisplatin and everolimus). The levels of phosphorylated p70S6K and 4E-BP1 after treatment with temsirolimus and everolimus were investigated by i...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Herbs treating Parkinson's disease
This article reviews herbs that have been documented to have a neuroprotective effect in vitro and in vivo Parkinson's disease (PD) model systems. We summarized the anti-Parkinsonian activities of herbs according to their genera. Plants corresponding to 47 genera were included in this review. These herbal medicines can be a substitute and precious source for anti-Parkinsonian drug discovery. The plant species in these families and genera whose pharmacological actions have been well characterized could possibly be good candidates for further studies to assess its ability to protect against neurodegenerative disease and pote...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
TDZD-8 pre-treatment in transient middle cerebral artery occlusion
This study aims to investigate the effects of a single pre-treatment dose of 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8), a glycogen synthase kinase-3β (GSK-3β) inhibitor, in a transient focal cerebral ischemia model. Twenty-eight male adult Wistar rats were subjected to right middle cerebral artery (MCA) occlusion via intraluminal thread technique for 60min under continuously cortical perfusion monitoring by laser-Doppler flowmetry. Rats were divided into two groups: control or treatment groups. In the treated group, TDZD-8 (5mg/kg; intravenously) was administered 10min before the onset of the MCA ischemi...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Matricaria Chamomilla extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine
Publication date: October–December 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 4 Author(s): Zahra Alibabaei , Zahra Rabiei , Samira Rahnama , Shiva Mokhtari , Mahmoud Rafieian-kopaei Alzheimer's disease (AD) is clinically characterized by progressive loss of cognitive abilities and usually is accompany with elevated oxidative stress. Chamomile is a plant with antioxidant activity with is currently used in Iranian folk medicine as sedative, analgesic, antipyretic and antispasmodic agent. The present study was investigated the effect of Matricaria chamomilla (MC) on learning and memory funct...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Anticancer effects of vecuronium bromide and cisatracurium besylate on lung cancer cells (A549), in vitro
Publication date: October–December 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 4 Author(s): Iddrisu Baba Yabasin , Mohammed Mohammed Ibrahim , Abass Adam , Sam-Awortwi Wilfred , Juventus Benogle Ziem , Peng Gao , Silvanus Kampo , Wen Qingping Neuromuscular blocking drugs are used in anesthesia and intensive care to provide skeletal muscle relaxation. However, literature has revealed that the effects of these drugs on cancer have not been widely studied. We tested the effects of two non-depolarising neuromuscular blocking drugs, vecuronium bromide and cisatracurium besylate on lung cance...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Screening for the modulation of neovessel formation in non-tumorigenic and tumorigenic conditions using three different plants native to Western ghats of India
Publication date: October–December 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 4 Author(s): B.R. Vijay Avin , Prabhu Thirusangu , C.K. Ramesh , V. Vigneshwaran , M.V. Prashanth Kumar , Riaz Mahmood , B.T. Prabhakar Angiogenesis is the growth of neovessels from existing vasculature. In diseases such as cancer excessive angiogenesis occurs when diseased cells produce abnormally large amounts of angiogenic factors. A wide range of plants contains compounds with angiogenesis modulating properties, which are currently known. The present study explores the screening for antiangiogenic potentia...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Cardioprotective effect of concomitant administration of trigonelline and sitagliptin on cardiac biomarkers, lipid levels, electrocardiographic and heamodynamic modulation on cardiomyopathy in diabetic Wistar rats
Conclusion We conclude that concomitant administration of TROG and SITA showed additive cardioprotective effect compared to monotherapy. (Source: Biomedicine and Aging Pathology)
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Synthesis, in silico preclinical evaluation, antidepressant potential of 5-substituted phenyl-3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1-carboxamides
Publication date: October–December 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 4 Author(s): Bijo Mathew , Jerad Suresh , S. Anbazhagan In the context of the discovery of new potential antidepressant candidates and in the light of promising antidepressant action of pyrazoline nucleus, a new series of thiophene bearing pyrazoline carboxamides were synthesized and examined for their antidepressant effect by two behavioural models viz. Forced Swim Test (FST) and Tail Suspension Test (TST). Neurotoxicity of the compounds were accessed by rotarod test. The titled compounds were characterized by IR...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
Glutathione peroxidase-1 expression is up-regulated by ozone therapy in ApoE deficient mice
Publication date: October–December 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 4 Author(s): Livan Delgado-Roche , Julio R. Fernández , Dalia R. Álvarez The role of glutathione peroxidase-1 (GPx1) in limiting the oxidative risk for atherogenesis is increasingly recognized. Therapeutic strategies, designed to augment cellular endogenous defense systems have been identified as a promising approach to control oxidative stress-associated diseases, including atherosclerosis. Ozone therapy regulates oxidative metabolism and prevents oxidative stress-associated-chronic diseases. Thus, the present ...
Source: Biomedicine and Aging Pathology - November 1, 2014 Category: Biomedical Science Source Type: research
