Liver damage associated with exposure to aspirin and diazinon in male rats and the ameliorative effect of selenium

Conclusions The present study indicates that liver enzymes, histopathology and immunoreactivity of caspase-3 would trigger ASA- and DIA-induced liver injury. The severities of such observations were more pronounced in their combined exposure. Combination therapy with Se restored these alterations to within the normal limits and prevents disruptions of liver structures. The data throw light on the problem of simultaneous exposure to OPIs and commonly used drugs especially that are metabolised by CYP450. Accordingly, ASA should be avoided since many of the adverse effects associated with these drugs are similar to the complications of chronic liver disease especially of agricultural workers in developing countries, where the handling of drugs without medical prescription. We suppose that antioxidant supplementation may be beneficial for the people using ASA for longer periods.
Source: Biomedicine and Aging Pathology - Category: Biomedical Science Source Type: research