Oxidant/antioxidant status in subjects with HIV infection in different clinical conditions

Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): Ivón González-Blanco , Vianka Calás-Hechavarria , Rosario Gravier-Hernández , Daniel Pérez-Correa , Angélica Reyes-Pérez , Daymé Hernández-Requejo , Mariela Guevara-García , Viviana García-Mir , Lizette Gil-del Valle , Olga Sonia León-Fernández , L Jorge Pérez-Ávila Infection by human immunodeficiency virus (HIV) causes persistent chronic inflammation with sustained reactive oxygen species generation. An increasing number of studies underline the impact of the pathogenetic role of high-grade local and systemic oxidative stress in the evolution of HIV infection. The aim of this study was to investigate the redox status in HIV individuals of different clinical conditions. Also progression and rutinaries biomarkers were evaluated. Blood samples were drawn from 120 HIV positive (age 44±13years) and 40 presumable healthy (age 47±4 years) subjects. The HIV individuals were divided in three groups according clinical conditions: asymptomatic, aids (acquired immune deficiency syndrome) and aids with delayed diagnosis. Total peroxide, malondialdehyde and advanced oxidation protein products as damage indexes and antioxidant responses (glutathione, peroxidation potential, superoxide dismutase and catalase) were determined from the blood samples. Also haematological and chemical indexes and progression indexes (viral load, T CD4+ lymphocyte a...
Source: Biomedicine and Aging Pathology - Category: Biomedical Science Source Type: research