Ameliorating effect of Phoenix dactylifera on lambda cyhalothrin induced biochemical, hematological and hepatopathological alterations in male wistar rats

Publication date: July–September 2014 Source:Biomedicine & Aging Pathology, Volume 4, Issue 3 Author(s): Mani Ramadhas , Krishnan Palanisamy , Munisamy Sudhagar , Vinayagam Magendira Mani Lambda cyhalothrin (LTC) is a synthetic pyrethroid insecticide, widely used to control insect pests in agriculture, public health, and homes and gardens. In the present study, an attempt has been made to study the effect of lambda cyhalothrin on biochemical, hematological parameters and ameliorating effects of palm dates (Phoenix dactylifera) in male wistar rat. Adult male Wistar rats were divided into four different groups. Group I served as control; group II received lambda cyhalothrin at a dose of 8mg/kg (1/10 LD50) dissolved in water for 21 days orally; group III received P. dactylifera (200mg/kg BW for 21 days) orally; group IV P. dactylifera alone treated. LTC-induced liver toxicity was measured by the increased activities of serum hepatic marker enzymes like aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, along with increased elevation of lipid peroxidation and reduction in the levels of enzymic and non-enzymic antioxidants levels. Lambda cyhalothrin exposure leads to adverse effects on hematological parameters including erythrocyte (RBCs) and leukocyte (WBCs) counts, hemoglobin concentration (Hb), hematocrit (Hct) and blood indices (MCV and MCH). However, treatment with P. dactylifera normalized the levels of hepatic mar...
Source: Biomedicine and Aging Pathology - Category: Biomedical Science Source Type: research