Effect of long intake of aspartame on ionic imbalance in immune organs of immunized wistar albino rats

This study focus is to understand whether the oral administration of aspartame (40mg/kg b.w.) for 90days, have any effect on membrane bound ATPase's, which may cause ionic disproportion and imbalance the homeostasis of immune organs in wistar albino rats. To mimic human methanol metabolism, folate deficient rats were used. After 90days of aspartame administration, showed a significant alteration in membrane bound ATPase's and serum ions. Excess free radical generation is confirmed by increase in lipid peroxidation and nitric oxide level. This study concludes that oral administration of aspartame (40mg/kg b.w.) for longer duration altered the homeostasis of immune organs, may cause oxidative stress in immune organs of wistar albino rats.
Source: Biomedicine and Aging Pathology - Category: Biomedical Science Source Type: research