Best Practice and Research. Clinical Rheumatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Update on the epidemiology, risk factors, and disease outcomes of axial spondyloarthritis
Publication date: Available online 16 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Clementina López-Medina, Anna MoltóAbstractAxial spondyloarthritis (axSpA) is the prototype of a class of a rheumatic chronic inflammatory disease named spondyloarthritis (SpA).The prevalence of axSpA ranges between 0.1% and 1.4% globally, hence showing geographic differences that can be explained mostly by the prevalence of the HLA-B27 antigen. However, not many studies have evaluated the incidence of this disease.Inflammation may be initiated in the enthesis as a consequence of the action of IL-23, which ...
Source: Best Practice and Research Clinical Rheumatology - November 17, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis
This article reviews the new developments in RA research and discusses the latest insights into epidemiology, risk factors, predisease states, and outcomes. (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - November 17, 2018 Category: Rheumatology Source Type: research

Comorbidities in spondyloarthritis including psoriatic arthritis
Publication date: Available online 15 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Anna Moltó, Maxime DougadosAbstractComorbidities in spondyloarthritis (SpA) including psoriatic arthritis have to be differentiated to the concept of clinical features of SpA (e.g., uveitis, psoriasis, and inflammatory bowel disease). In addition to atherosclerosis-related cardiovascular diseases, the most frequent comorbidities in SpA are osteoporosis, fibromyalgia, and depression.Moreover, the current available drug therapies (e.g., NSAIDs, corticosteroids, and biologics) might increase the risk of some co...
Source: Best Practice and Research Clinical Rheumatology - November 16, 2018 Category: Rheumatology Source Type: research

Introduction, epidemiology and classification of vasculitis
Publication date: Available online 16 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Richard A. Watts, Joanna RobsonAbstractClassification of the vasculitides has been traditionally based on vessel size. The American College of Rheumatology (ACR) criteria were developed in the 1980s and published in 1990 before the development of ANCA testing and modern imaging techniques such as MRI and PET scanning, and therefore, these criteria are not fit for use in 2010s. The Chapel Hill Consensus Conference provided a framework for defining various types of vasculitis. In the next two years, new classif...
Source: Best Practice and Research Clinical Rheumatology - November 16, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors, and outcomes of systemic vasculitides
Publication date: Available online 2 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Alvise Berti, Christian DejacoAbstractAntineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) and giant cell arteritis (GCA) are the most common primary systemic vasculitides of the adult population, while polymyalgia rheumatica (PMR) is a clinical syndrome often associated with GCA.Incidence and prevalence rates of AAV have been increasing in the last decades, whereas those of GCA and PMR have remained stable. The mutual interplay between environmental and genetic risk factors leading to the ...
Source: Best Practice and Research Clinical Rheumatology - November 3, 2018 Category: Rheumatology Source Type: research

Nonradiographic axial spondyloarthritis
This article reviews the current state of the literature as the understanding of this disease spectrum expands. The conceptual history and terminology, genetics, and epidemiology are reviewed. The clinical manifestations, diagnostic approach, and measures of disease activity are examined. Finally the current treatment modalities and recommendations and the research agenda for nr-axSpA are reviewed. With the advent of new criteria, the disease spectrum can be studied in a systematic manner. These data have enriched our knowledge that reflects an earlier or milder form of disease on a spectrum same as that of ankylosing spon...
Source: Best Practice and Research Clinical Rheumatology - November 3, 2018 Category: Rheumatology Source Type: research

Uveitis and spondyloarthropathies
Publication date: Available online 25 October 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Srilakshmi M. Sharma, Daniel JacksonAbstractUveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies (SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and inflammatory bowel disease (IBD), occurring in both adults and children with SpA. Uveitis occurs with varying frequency according to the SpA subtype (33% in AS, 6–9% in PsA, 25% in ReA, 13% in undifferentiated SpA and 2–5% in IBD), the presence of HLA-B27 and with increasing duration ...
Source: Best Practice and Research Clinical Rheumatology - October 26, 2018 Category: Rheumatology Source Type: research

Disease activity assessment in patients with psoriatic arthritis
Publication date: Available online 11 October 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Andreas Kerschbaumer, Josef S. Smolen, Daniel AletahaAbstractPsoriatic arthritis (PsA) is an inflammatory disease in patients with a personal or family history of psoriasis. While synovitis is the major hallmark, enthesitis, dactylitis, axial inflammation, and skin and nail involvement are variable in prevalence and severity. The assessment of disease activity is important to determine the treatment target (“Treat-to-Target”) as well as early response to therapy, because a prolonged ineffective medication ...
Source: Best Practice and Research Clinical Rheumatology - October 11, 2018 Category: Rheumatology Source Type: research

Pediatric forms of vasculitis
Publication date: Available online 10 October 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Seza Özen, Hafize Emine Sönmez, Selcan DemirAbstractPrimary vasculitides that affect children are a challenging and complex group of disorders that may involve any system of the body and lead to significant morbidity and mortality. In recent years, there have been significant advances in the field of childhood vasculitides, including the development of classification criteria and outcome assessment. Although some forms of vasculitis occur in both children and adults, considerable differences exist between ch...
Source: Best Practice and Research Clinical Rheumatology - October 10, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors, and disease outcomes of psoriatic arthritis
Publication date: Available online 5 October 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Dilek Solmaz, Lihi Eder, Sibel Zehra AydinAbstractPsoriatic arthritis (PsA) is a chronic inflammatory disease that affects different structures of the musculoskeletal system in addition to the skin and the nail. The complexity of the disease had been a barrier to understand the pathogenesis and define valid outcome tools; however, our understanding about the disease has considerably increased with time mainly because of the advances in imaging, new discoveries in genetics and underlying inflammatory pathways, a...
Source: Best Practice and Research Clinical Rheumatology - October 6, 2018 Category: Rheumatology Source Type: research

Investigations in systemic vasculitis – The role of imaging
Publication date: Available online 25 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Wolfgang A. Schmidt, Daniel BlockmansAbstractImaging plays an increasing role for confirming a suspected diagnosis of giant cell arteritis (GCA) or Takayasu arteritis (TAK). Ultrasound, magnetic resonance imaging (MRI), and computed tomography demonstrate a homogeneous, most commonly concentric, arterial wall thickening. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) displays increased FDG uptake of inflamed artery walls delineating increased metabolism. Ultrasound and MRI are recommended to...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Thumb base osteoarthritis: A hand osteoarthritis subset requiring a distinct approach
Publication date: Available online 26 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Margreet Kloppenburg, Sjoerd van Beest, Féline P.B. KroonAbstractHand osteoarthritis (OA) is usually a polyarticular disease, preferentially affecting the thumb base (TB) and interphalangeal joints. TB OA alone is generally not addressed separately, but as a part of hand OA. Studies have shown that OA in the TB joints clusters together, as does OA in the interphalangeal joints, supporting it as a distinct subset. Further support for this view comes from a specific risk profile, influence on clinical burden,...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Gut inflammation in spondyloarthritis
Publication date: Available online 27 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Aroldo Rizzo, Angelo Ferrante, Giuliana Guggino, Francesco CicciaAbstractSpondyloarthritis (SpA) is a group of related diseases sharing common etiopathogenic mechanisms and clinical manifestations supported by a complex genetic predisposition. Gut inflammation is present in patients with SpA including patients showing clinically evident intestinal inflammation in the form of Crohn's disease or ulcerative colitis and patients who despite the absence of signs and symptoms of intestinal inflammation display a s...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors, and disease outcomes of systemic lupus erythematosus
Publication date: Available online 27 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Irini Gergianaki, Alessandra Bortoluzzi, George BertsiasAbstractObtaining an updated view of the epidemiology, risk factors, and prognosis of systemic lupus erythematosus (SLE) is pivotal to our understanding of the disease burden. Recent community-based studies with comprehensive methodology provided more accurate disease occurrence estimates and suggested that SLE may be more frequent than previously thought. Gender, race, and socioeconomic status are important disease determinants, and there is increasing...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology and disease outcome of Familial Mediterranean fever
Publication date: Available online 29 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Seza ÖzenAbstractAutoinflammatory diseases (AIDs) are diseases of the innate immune system, with clinical and laboratory evidence of attacks of inflammation. The more common AIDs are those associated with periodic fevers: Familial Mediterranean fever (FMF); Mevalonate Kinase Deficiency (MKD)/Hyperimmunoglobulin D Syndrome (HIDS); Cryopyrin-associated Autoinflammatory Syndrome (CAPS); and Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS). Classification criteria have been developed for all ...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research