Best Practice and Research. Clinical Rheumatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Implementation science to reduce the prevalence and burden of MSK disorders following sport and exercise-related injury
Publication date: Available online 28 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Evert Verhagen, Femke van NassauAbstractAlthough safety in sports and physical activity is an important prerequisite for continuing participation and maintenance of a healthy, physically active lifestyle, to date little effort has been placed upon moving evidence into preventive practice. Amongst researchers it is still often assumed that a program will disseminate itself after proven to be effective. Recently, however, there has been an increased recognition of the importance of theory-driven approaches to e...
Source: Best Practice and Research Clinical Rheumatology - February 28, 2019 Category: Rheumatology Source Type: research

Efficacy and survival of golimumab with and without methotrexate in patients with psoriatic arthritis: A retrospective study from daily clinical practice
Publication date: Available online 27 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Kassem Sharif, Omer Gendelman, Pnina Langevitz, Tatiana Reitblat, Abdulla Watad, Yehuda Shoenfeld, Josef Azuri, Howard Amital, Nicola Luigi Bragazzi, Ora ShovmanAbstractGolimumab is a recombinant human monoclonal antibody targeted against tumour necrosis factor-alpha (TNF-α). Golimumab is effective in the management of patients with active psoriatic arthritis (PsA).The aim of this study is to evaluate the clinical efficacy and survival of golimumab monotherapy versus co-administration with methotrexate (MTX)...
Source: Best Practice and Research Clinical Rheumatology - February 27, 2019 Category: Rheumatology Source Type: research

Rheumatoid arthritis and thyroid dysfunction: A cross-sectional study and a review of the literature
Publication date: Available online 26 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Hussein Mahagna, Alyssa Caplan, Abdulla Watad, Nicola Luigi Bragazzi, Kassem Sharif, Shmuel Tiosano, Naim Mahroum, Hen Hendel, Yehuda Shoenfeld, Doron Comaneshter, Arnon D. Cohen, Howard AmitalAbstractThyroid dysfunction appears to show increased prevalence in many autoimmune diseases; however, this comorbidity has not been properly investigated in patients with RA. This issue was addressed in this cross-sectional study.Using the database of the Clalit Health Services (CHS) in Israel, RA patients were paired ...
Source: Best Practice and Research Clinical Rheumatology - February 26, 2019 Category: Rheumatology Source Type: research

Mutants of β2-glycoprotein I: Their features and potent applications
Publication date: Available online 26 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Lianhua Shen, Nuriza Ulul Azmi, Xian Wen Tan, Shinsuke Yasuda, Arum Tri Wahyuningsih, Junko Inagaki, Kazuko Kobayashi, Eiji Ando, Takanori Sasaki, Eiji MatsuuraAbstractβ2-Glycoprotein I (β2GPI) is a highly-glycosylated plasma protein composed of five homologous domains which regulates coagulation, fibrinolysis, and/or angiogenesis by interacting to negatively charged hydrophobic molecules and/or with plasminogen and its metabolites. The present study focused on structural and functional characterization of...
Source: Best Practice and Research Clinical Rheumatology - February 26, 2019 Category: Rheumatology Source Type: research

Mortality of patients with systemic lupus erythematosus admitted to the intensive care unit – A retrospective single-center study
Publication date: Available online 23 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Guy Zamir, Yael Haviv-Yadid, Kassem Sharif, Nicola Luigi Bragazzi, Abdulla Watad, Amir Dagan, Howard Amital, Yehuda Shoenfeld, Ora ShovmanAbstractSystemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that results in increased morbidity and mortality. Under certain conditions, patients with SLE may be admitted to the intensive care unit (ICU) secondary to infectious disease flare-ups or other non-SLE disease conditions that are aggravated by SLE. The aim of our study was to investigate the c...
Source: Best Practice and Research Clinical Rheumatology - February 25, 2019 Category: Rheumatology Source Type: research

Managing low back pain in active adolescents
Publication date: Available online 23 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Kieran O'Sullivan, Mary O'Keeffe, Bruce B. Forster, Sadia Raheez Qamar, Andrew van der Westhuizen, Peter B. O'SullivanAbstractAdolescent low back pain has received limited research attention despite its potentially considerable impact on quality of life. The role of diagnostic triage to identify serious or specific pathology and/or order relevant investigations is considered. An overview of contemporary pain mechanisms is provided, with specific reference to the wide range of risk factors for persistent low ...
Source: Best Practice and Research Clinical Rheumatology - February 25, 2019 Category: Rheumatology Source Type: research

Rethinking patellofemoral pain: Prevention, management and long-term consequences
Publication date: Available online 22 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Kay M. Crossley, Marienke van Middelkoop, Christian J. Barton, Adam G. CulvenorAbstractPatellofemoral pain is one of the most common knee complaints, particularly among physically active young individuals. Although once thought to be self-limiting, prospective studies have demonstrated the propensity towards the chronicity of patellofemoral pain (PFP). The pathogenesis of PFP is complex, with multiple interactive pathways suggested to contribute to its onset and persistence. Quadriceps weakness is one of the ...
Source: Best Practice and Research Clinical Rheumatology - February 23, 2019 Category: Rheumatology Source Type: research

Mimickers of neuropsychiatric manifestations in systemic lupus erythematosus
Publication date: Available online 22 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jaqueline Cristina de Amorim, Aline Kuhl Torricelli, Renan Bazuco Frittoli, Aline Tamires Lapa, Sergio San Juan Dertkigil, Fabiano Reis, Lilian TL. Costallat, Marcondes Cavalcante França Junior, Simone AppenzellerAbstractSystemic lupus erythematosus (SLE), presenting with new onset or worsening neuropsychiatric (NP) symptoms, is a challenge in clinical practice. Mimickers such as infections, drug-induced side effects, metabolic abnormalities, malignancies, and alcohol-related disorders have to be excluded, b...
Source: Best Practice and Research Clinical Rheumatology - February 23, 2019 Category: Rheumatology Source Type: research

Current trends in sport injury prevention
Publication date: Available online 23 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Carolyn A. Emery, Kati PasanenAbstractParticipation in sport and recreation has important positive implications for public health across the lifespan; however, the burden of sport-related musculoskeletal injury is significant, with the greatest risk being in youth and young adults. Moving upstream to primary prevention of injury is a public health priority that will have significant implications for reducing the long-term consequences of musculoskeletal injury including early post-traumatic osteoarthritis. Th...
Source: Best Practice and Research Clinical Rheumatology - February 23, 2019 Category: Rheumatology Source Type: research

Rituximab induction without maintenance for granulomatosis with polyangiitis and dialysis – Case report and literature review
We describe a case of a 32-year-old woman admitted for pulmonary infiltrates and acute renal failure. Autoimmune workup revealed an elevated titer of proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA). The diagnosis of granulomatosis with polyangiitis (GPA) was confirmed by renal biopsy. The patient received induction therapy with IV rituximab (375 mg/m2 per week for 4 weeks) along with systemic high-dose IV corticosteroids and one pulse of IV cyclophosphamide (1000 mg). Rapid deterioration of her kidney function led to pulmonary edema requiring intensive care (ICU) hospitalization. Dialysis and plasmapheresis w...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Youth sport: Friend or Foe?
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Carly D. McKay, Sean P. Cumming, Tracy BlakeAbstractParticipation in youth sport has been promoted as part of a healthy lifestyle, with benefits for physical fitness, social development, and mental wellbeing. Yet, sport carries an inherent risk of injury, which for young athletes may have both immediate and long-term consequences. Amidst significant public debate about the pros and cons of youth sport, this review considers the physiological, psychological, and social factors that inform decisions around yout...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Do the benefits of participation in sport and exercise outweigh the negatives? An academic review
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Kathryn Mills, Dean Dudley, Natalie J. CollinsAbstractPublic health campaigns promote regular exercise and physical activity. These campaigns are founded on global recommendations that a combination of aerobic and resistance exercise is required, on a weekly basis, to maximise physical and mental health. However, participation in all forms of sports and physical activity has inherent risks that need to be considered by both health practitioners making activity recommendations and the people participating. Thi...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

The diagnostic value of 14-3-3η protein levels in patients with rheumatoid arthritis
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): O. Shovman, B. Gilburd, A. Watad, H. Amital, P. Langevitz, N.L. Bragazzi, M. Adawi, D. Perez, G. Bornstein, C. Grossman, M. Lidar, M. Blank, J. Azuri, N.K. Biln, A. Marotta, Y. ShoenfeldAbstract14-3-3η may represent a useful diagnostic biomarker for rheumatoid arthritis (RA). We assessed the prevalence and serum levels of 14-3-3η in patients with RA and in patients with other rheumatic diseases.Serum levels of 14-3-3η were measured in 96 patients with RA, in 101 patients with other rheumatic diseases, and ...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Outcomes of patients with systemic sclerosis treated with tocilizumab: Case series and review of the literature
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Galia Zacay, Yair LevyAbstractThe treatment of systemic sclerosis (SSc) presents a clinical challenge because of the progressive nature of the disease, relatively poor prognosis, and lack of a proven treatment. In the last 10 years, several studies demonstrated the importance of interleukin 6 (IL6) as a pivotal cytokine in the development of fibrosis and angiopathy, especially in SSc. Tocilizumab, an IL6 receptor antibody, has shown promising results for patients with SSc.A total of 16 patients with SSc were ...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

The sacroiliac joint – Victim or culprit
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): James Booth, Samuel MorrisAbstractIt is estimated that 10–30% of all low back pain is attributed to the sacroiliac joints. There are many challenges to diagnosing and treating the sacroiliac joints. Central to this challenge is determining whether the sacroiliac joint is the primary source of pain or dysfunction. This paper considers the complexities of diagnosis and management of sacroiliac joint dysfunction by providing a best evidence informed overview of the mechanics of the sacroiliac joint, the aetiol...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research