Best Practice and Research. Clinical Rheumatology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Checkpoint inhibitor-associated autoimmunity
Publication date: Available online 15 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Karim Ladak, Anne R. BassAbstractCheckpoint inhibitors (CI) have revolutionized the management of many cancers but can result in immune-related adverse events (IRAE). In this chapter, we review the clinical manifestations and management of the most common IRAE, plus less common IRAE, such as inflammatory arthritis, of particular interest to rheumatologists. We review the mechanism of action of CI, predictors of IRAE, and the impact of IRAE on cancer outcomes. The study of IRAE is in its infancy; there are very f...
Source: Best Practice and Research Clinical Rheumatology - April 16, 2019 Category: Rheumatology Source Type: research
Malignancy and rheumatoid arthritis: Epidemiology, risk factors and management
Publication date: Available online 15 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Diederik De Cock, Kimme HyrichAbstractRheumatoid arthritis (RA) is a chronic inflammatory condition that can result in pain and functional disability. It is also associated with an increased occurrence of comorbidities, including an increased risk of certain cancers such as lung cancer and lymphoma. The aetiopathogenesis of this increased cancer risk is likely multifactorial and includes shared risk factors as well as chronic inflammation. There is also a concern that the treatment for RA itself may increase thi...
Source: Best Practice and Research Clinical Rheumatology - April 16, 2019 Category: Rheumatology Source Type: research
Management of complex gout in clinical practice: Update on therapeutic approaches
Publication date: Available online 12 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Ravi K. Narang, Nicola DalbethAbstractIncreasing therapeutic options are available for gout management. Anti-inflammatory agents are used in the acute management of gout flares, and interleukin-1 inhibitors are effective for those unable to take conventional anti-inflammatory treatments. Lowering of serum urate remains the cornerstone of effective long-term management. Allopurinol is the first-line urate-lowering therapy, and a gradual dose-escalation strategy to serum urate target is recommended. Febuxostat and...
Source: Best Practice and Research Clinical Rheumatology - April 14, 2019 Category: Rheumatology Source Type: research
Recent advances in spondyloarthritis
Publication date: Available online 13 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Denis Poddubnyy, Nigil Haroon (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - April 14, 2019 Category: Rheumatology Source Type: research
An overview of biologic disease-modifying antirheumatic drugs in axial spondyloarthritis and psoriatic arthritis
Publication date: Available online 21 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Anthony So, Robert Davies InmanAbstractBiologic disease-modifying antirheumatic drugs (bDMARDs) are engineered proteins with high affinity for various proinflammatory immune mediators to reduce inflammation and its sequelae in various rheumatic diseases. These medications, introduced at the advent of the 21st century, have revolutionized the treatment of axial spondyloarthritis (including ankylosing spondylitis) and psoriatic arthritis. Currently approved bDMARDs for axial spondyloarthritis are etanercept, infli...
Source: Best Practice and Research Clinical Rheumatology - March 21, 2019 Category: Rheumatology Source Type: research
A pragmatic approach to prevent post-traumatic osteoarthritis after sport or exercise-related joint injury
Publication date: Available online 14 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jackie L. Whittaker, Ewa M. RoosAbstractLower extremity musculoskeletal injuries are common in sport and exercise, and associated with increased risk of obesity and post-traumatic osteoarthritis (PTOA). Unlike other forms of osteoarthritis, PTOA is common at a younger age and associated with more rapid progression, which may impact career choices, long-term general health and reduce quality of life. Individuals who suffer an activity-related joint injury and present with abnormal joint morphology, elevated adipo...
Source: Best Practice and Research Clinical Rheumatology - March 15, 2019 Category: Rheumatology Source Type: research
Current trends in tendinopathy management
Publication date: Available online 8 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Tanusha B. Cardoso, Tania Pizzari, Rita Kinsella, Danielle Hope, Jill L. CookAbstractTendinopathy (pain and dysfunction in a tendon) is a prevalent clinical musculoskeletal presentation across the age spectrum, mostly in active and sporting people. Excess load above the tendon's usual capacity is the primary cause of clinical presentation. The propensity towards chronicity and the extended times for recovery and optimal function and the challenge of managing tendinopathy in a sporting competition season make this...
Source: Best Practice and Research Clinical Rheumatology - March 9, 2019 Category: Rheumatology Source Type: research
Epilepsy is not statistically associated with systemic sclerosis but significantly impacts on mortality: A real-world epidemiological survey-based study
In conclusion, whilst epilepsy and SSc are not significantly associated, epilepsy is a predictor of mortality in SSc patients. (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - March 8, 2019 Category: Rheumatology Source Type: research
Cardiovascular morbidity and mortality in ankylosing spondylitis and psoriatic arthritis
Publication date: Available online 6 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jean W. Liew, Sofia Ramiro, Lianne S. GenslerAbstractThe cardiovascular burden in inflammatory rheumatic diseases is well recognized. Recently, this burden has been highlighted in ankylosing spondylitis (also known as radiographic axial spondyloarthritis) and psoriatic arthritis. We review the cardiovascular morbidity and mortality in these diseases, as well as the prevalence and incidence of traditional cardiovascular risk factors. We examine the contribution of anti-inflammatory therapy with nonsteroidal anti-i...
Source: Best Practice and Research Clinical Rheumatology - March 7, 2019 Category: Rheumatology Source Type: research
Current trends in sport and exercise hip conditions: Intra-articular and extra-articular hip pain, with detailed focus on femoroacetabular impingement (FAI) syndrome
Publication date: Available online 4 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Joanne Kemp, Alison Grimaldi, Joshua Heerey, Denise Jones, Mark Scholes, Peter Lawrenson, Sally Coburn, Matthew KingAbstractMusculoskeletal conditions, such as hip pain are leading causes of pain and disability. Hip pain is the second most common cause of lower limb musculoskeletal pain, and is commonly seen in active individuals. Hip and groin pain may have intra-articular and extra-articular causes. Femoroacetabular impingement (FAI) syndrome and the associated pathologies are common intra-articular causes of h...
Source: Best Practice and Research Clinical Rheumatology - March 6, 2019 Category: Rheumatology Source Type: research
Time to diagnosis of fibromyalgia and factors associated with delayed diagnosis in primary care
Publication date: Available online 4 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Omer Gendelman, Howard Amital, Yael Bar-On, Dana Ben-Ami Shor, Daniela Amital, Shmuel Tiosano, Varda Shalev, Gabriel Chodick, Dahlia WeitzmanAbstractFibromyalgia is a complex disorder, and its diagnosis often comprises a challenge for physicians.We aimed to assess the time from the appearance of early symptoms to the definite diagnosis of fibromyalgia and to delineate patient and physician factors associated with this delay.The database of a large healthcare services provider was searched for all fibromyalgia pat...
Source: Best Practice and Research Clinical Rheumatology - March 6, 2019 Category: Rheumatology Source Type: research
Peripheral spondyloarthritis: Concept, diagnosis and treatment
Publication date: Available online 2 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Anna Molto, Joachim SieperAbstractPeripheral spondyloarthritis refers to spondyloarthritis with predominant peripheral (arthritis, enthesitis or dactylitis) involvement. Diagnosis can be challenging, particularly in the absence of SpA extra-articular manifestations such as uveitis, psoriasis or inflammatory bowel disease. Evaluation of disease activity should always include assessment of objective signs of inflammation, particularly in the presence of enthesitis as the sole peripheral manifestation, mainly due to...
Source: Best Practice and Research Clinical Rheumatology - March 4, 2019 Category: Rheumatology Source Type: research
Disease modification in axial spondyloarthritis
Publication date: Available online 2 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Ismail Sari, Nigil HaroonAbstractThe concept of “disease modification” refers to an intervention that modifies the natural clinical course of the disease along with improvement of symptoms. With regard to this, providing treatment that improves clinical signs and symptoms of axial spondyloarthritis (axSpA) and that impacts disease pathogenesis by slowing/halting bone formation is the main goal of this concept. It has been proven that currently available treatments including biologics and nonsteroidal anti-inf...
Source: Best Practice and Research Clinical Rheumatology - March 4, 2019 Category: Rheumatology Source Type: research
Autoinflammatory/autoimmunity syndrome induced by adjuvants (Shoenfeld's syndrome) in patients after a polypropylene mesh implantation
In conclusion, 40 patients developed symptoms of a systemic illness after a mesh operation. All patients fulfilled the diagnostic criteria for ASIA. One quarter of the patients had an immunodeficiency, whereas in approximately half of the patients, an autoimmune disease developed. We postulate that PP mesh implants may increase the risk of developing (auto)immune diseases by acting as an adjuvant. (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - March 1, 2019 Category: Rheumatology Source Type: research
Central nervous system involvement in rheumatoid arthritis patients and the potential implications of using biological agents
Publication date: Available online 27 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Fabiola Atzeni, Rossella Talotta, Ignazio Francesco Masala, Maria Chiara Gerardi, Roberto Casale, Piercarlo Sarzi-PuttiniAbstractCentral nervous system (CNS) involvement is quite unusual in patients with rheumatoid arthritis (RA), although cerebral vasculitis, rheumatoid nodules and meningitis have all been reported, and patients with RA may also have CNS comorbidities such as stroke and neuro-degenerative and demyelinating syndromes. It has been found that biological drugs, especially anti-tumour necrosis fa...
Source: Best Practice and Research Clinical Rheumatology - February 28, 2019 Category: Rheumatology Source Type: research
