Best Practice and Research. Clinical Rheumatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Genetics in ankylosing spondylitis – Current state of the art and translation into clinical outcomes
Publication date: Available online 3 October 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Matthew A. Brown, B. Paul WordsworthAbstractAnkylosing spondylitis (AS) is the prototypic form of axial spondyloarthritis (axSpA). It is highly heritable, with studies conducted in twins and in unrelated cases and controls showing that the heritability for AS is much higher than those for inflammatory bowel disease or rheumatoid arthritis. To date, 116 loci have been identified, contributing to 28% of the genetic variation in the disease. These loci provide important clues into pathogenic pathways in the diseas...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors and disease outcomes of Behçet's disease
Publication date: Available online 21 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Nurullah AkkoçAbstractBehçet's disease (BD) may be regarded as a polygenic autoinflammatory disease although adaptive immune system has also been implicated in pathogenesis. Different classification criteria sets exist for BD, including the new “International Criteria for BD.” The pooled prevalence of BD was calculated as 10.3 per 100,000 population globally. BD is common along the Silk Road, including Turkey. Male sex and early onset are associated with a more severe disease course. For the follow-up ...
Source: Best Practice and Research Clinical Rheumatology - September 22, 2018 Category: Rheumatology Source Type: research

Prognosis and future developments in vasculitis
Publication date: Available online 22 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): N. Basu, M. Karabayas, C. PuseyAbstractThe prognosis of ANCA-associated vasculitis has been transformed in recent years. Once it was a set of invariably acute and fatal conditions, but these disorders are currently considered to be chronic diseases. This change is largely attributable to earlier diagnosis and the careful application of immunotherapeutics. However, patients still experience premature mortality, relapse, comorbid ill health and poor quality of life. Mortality rates in large-vessel vasculitis a...
Source: Best Practice and Research Clinical Rheumatology - September 22, 2018 Category: Rheumatology Source Type: research

Oral treatment options for AS and PsA: DMARDs and small-molecule inhibitors
Publication date: Available online 20 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jonathan Chan, Dafna GladmanAbstractSpondyloarthritis (SpA) represents a group of common diseases that share a number of characteristic clinical manifestations including peripheral arthritis, spondylitis, enthesitis, and dactylitis. Additionally, they can often be associated with extra-articular manifestations including psoriasis, anterior uveitis, and inflammatory bowel disease. The two most widely studied clinical phenotypes are ankylosing spondylitis and psoriatic arthritis.Although a number of biologic a...
Source: Best Practice and Research Clinical Rheumatology - September 20, 2018 Category: Rheumatology Source Type: research

Evolving concepts of new bone formation in axial spondyloarthritis: Insights from animal models and human studies
Publication date: Available online 20 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Rik J. Lories, Nigil HaroonAbstractNew bone formation potentially leading to ankylosis of the sacroiliac joints and the spine is the main type of structural damage to the skeleton that characterizes axial spondyloarthritis. New data from animal models, imaging, and patient cohort studies support the view that sustained suppression of inflammation by therapeutic interventions can slow down the ankylosing process, at least in a large proportion of the patients. Although specific growth factor molecular signali...
Source: Best Practice and Research Clinical Rheumatology - September 20, 2018 Category: Rheumatology Source Type: research