Best Practice and Research. Clinical Rheumatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evidence-based recommendations for the management of anterior cruciate ligament (ACL) rupture
The objectives of management are to restore knee function, address psychological barriers to activity participation, prevent further injury and osteoarthritis, and optimize long-term quality of life. The three main treatment options for ACL rupture are (1) rehabilitation as first-line treatment (followed by ACL reconstruction (ACLR) in patients, who develop functional instability), (2) ACLR and post-operative rehabilitation as the first-line treatment, and (3) pre-operative rehabilitation followed by ACLR and post-operative rehabilitation. We provide practical recommendations for informing and discussing management options...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Emerging treatment options for spondyloarthritis
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Murat Torgutalp, Denis PoddubnyyAbstractThe management of spondyloarthritis (SpA) has substantially changed as a consequence of the introduction of biologic disease-modifying antirheumatic drugs (bDMARDs). However, the treatment options in patients with axial SpA (axSpA) not responding to nonsteroidal anti-inflammatory drugs (NSAIDs) had been restricted to tumor necrosis factor alpha (TNFα) inhibitors for almost 15 years. With the approval of secukinumab, an interleukin (IL)-17A inhibitor, there is a new alt...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Choosing Wisely after a sport and exercise-related injury
Publication date: Available online 22 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Joshua R. Zadro, Ian A. Harris, Christina Abdelshaheed, Carolyn Broderick, Christian J. Barton, James Linklater, Christopher G. MaherAbstractLow-value care is receiving substantial attention in many fields of medicine but little-to-none in sports medicine. Common interventions for sport and exercise-related injuries include medical imaging, medication, surgery and rehabilitation, but there is emerging evidence of the inappropriate use of these interventions.This chapter aims to increase awareness of low-value...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Anti-DFS70 among HIV-positive individuals – A prospective study
Publication date: Available online 20 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Naim Mahroum, Dolores Perez, Ora Shovman, Abdulla Watad, Boris Gilburd, Howard Amital, Itzik Levy, Yehuda ShoenfeldAbstractAnti-DFS70 is an anti-nuclear antibody directed against the DFS70 protein, which is produced in response to several stressful events. Since its discovery, this autoantigen–antibody complex has drawn the attention of many researchers, yet many questions remain unanswered. The DFS70 protein is crucial for HIV integration into the host DNA; however, the relationship between anti-DFS70 and ...
Source: Best Practice and Research Clinical Rheumatology - February 20, 2019 Category: Rheumatology Source Type: research

Overview of osteo-articular involvement in systemic sclerosis: Specific risk factors, clinico-sonographic evaluation, and comparison with healthy women from the French OFELY cohort
Publication date: Available online 20 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Sara Thietart, Karine Louati, Marc Gatfosse, Elisabeth Sornay-Rendu, Emeline Gaigneux, Lucie Lemeunier, Philippe Delmaire, Sébastien Riviere, Thibault Mahevas, Jérémie Sellam, Francis Berenbaum, Olivier Fain, Chapurlat Roland, Arsène MekinianAbstractOsteoarticular involvement in systemic sclerosis (SSc) is frequent and varied. Data are scarce on the prevalence and risk factors of osteoporosis (OP). We aimed to assess clinical parameters, radiological parameters, US articular involvements, and the frequenc...
Source: Best Practice and Research Clinical Rheumatology - February 20, 2019 Category: Rheumatology Source Type: research

Toll-like receptor 2 is overexpressed in Familial Mediterranean fever patients and is inhibited by colchicine treatment
Conclusions: TLR2 activation was upregulated in monocytes of FMF patients, and colchicine inhibited this upregulation both in -vitro and in -vivo. This indicates that elevated expression of TLR2 promotes the production of pro-inflammatory cytokines, which may contribute to uncontrolled inflammation in FMF. (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - February 19, 2019 Category: Rheumatology Source Type: research

Serum concentration of surfactant protein D in patients with systemic sclerosis: The potential marker of the interstitial lung disease severity
Publication date: Available online 14 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Anida Grosicka, Ahmed Manasar, Eugene J. Kucharz, Przemyslaw J. KotylaAbstractPulmonary involvement is a severe manifestation of systemic sclerosis (SSc). The study was designed to determine the serum level of surfactant protein D (SP-D) in patients with SSc in relation to clinical and laboratory parameters as well as to analyze dynamics of changes of these indices within one year of observation.SP-D was assayed in 41 patients with SSc and 15 healthy controls. Additionally, pulmonary function tests, chest hig...
Source: Best Practice and Research Clinical Rheumatology - February 15, 2019 Category: Rheumatology Source Type: research

MMP3 is a reliable marker for disease activity, radiological monitoring, disease outcome predictability, and therapeutic response in rheumatoid arthritis
Publication date: Available online 14 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Aaron Lerner, Sandra Neidhöfer, Sandra Reuter, Torsten MatthiasAbstractMatrix metalloproteinase-3 or MMP3 also known as stromelysin-1 is an enzyme that is actively involved in joint destruction in rheumatoid arthritis (RA) patients. Screening the last three decades, it appears that serum levels of MMP3 reflect positively RA disease activity, joint and bone injury, and radiological erosion and predict disease outcome and drug responsiveness as summarized in several publications reporting outcomes on more than...
Source: Best Practice and Research Clinical Rheumatology - February 14, 2019 Category: Rheumatology Source Type: research

Corrigendum to “Overview of changes in RMD epidemiology and outcome development in the last 10 years” [Best Pract Res Clin Rheumatol 32 (2018) 169–173]
Publication date: Available online 7 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Suzanne M.M. Verstappen, Loreto Carmona (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - February 8, 2019 Category: Rheumatology Source Type: research

Advances in understanding the pathophysiology of spondyloarthritis
Publication date: Available online 31 January 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Rik J. LoriesAbstractProgressive understanding of the underlying pathophysiology of axial spondyloarthritis has successfully translated into innovative therapeutic strategies and successful management of patients in the clinic. This review summarizes the key roles of the pro-inflammatory cytokines tumor necrosis factor and interleukin-17 in the onset and progression of disease and how these cytokines are instrumental in shaping the concept that enthesitis is a key feature of axial spondyloarthritis. Advances i...
Source: Best Practice and Research Clinical Rheumatology - January 31, 2019 Category: Rheumatology Source Type: research

Index
Publication date: April 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 2Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: April 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 2Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Epidemiology of rheumatic and musculoskeletal diseases
Publication date: April 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 2Author(s): Suzanne M.M. Verstappen, Loreto Carmona (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Uveitis in the Spondyloarthopathies
Publication date: December 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 6Author(s): Srilakshmi M. Sharma, Daniel JacksonAbstractUveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies (SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and inflammatory bowel disease (IBD), occurring in both adults and children with SpA. Uveitis occurs with varying frequency according to the SpA subtype (33% in AS, 6–9% in PsA, 25% in ReA, 13% in undifferentiated SpA and 2–5% in IBD), the presence of HLA-B27 and with increasing duration...
Source: Best Practice and Research Clinical Rheumatology - December 6, 2018 Category: Rheumatology Source Type: research

Index
Publication date: February 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 1Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 5, 2018 Category: Rheumatology Source Type: research