Editorial Board
Publication date: February 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 1Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 5, 2018 Category: Rheumatology Source Type: research

Preface
Publication date: February 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 1Author(s): Raashid Ahmed Luqmani, David Jayne (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 5, 2018 Category: Rheumatology Source Type: research

Index
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Involvement of epigenetics in osteoarthritis
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): Rodrigo Coutinho de Almeida, Yolande F.M. Ramos, Ingrid MeulenbeltAbstractOsteoarthritis (OA) is the most prevalent chronic age-related arthritic disease that mainly affects the diarthrodial joints. Nevertheless, there is no treatment currently available that can effectively reduce symptoms or slow down or stop disease progression. The lack of disease-modifying therapies could be explained by the complex pathogenesis of OA, which is still not completely understood. Intertwined epigenetic mechanisms such as DNA...
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Role of the autonomic nervous system in osteoarthritis
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): Alice Courties, Jérémie Sellam, Francis BerenbaumAbstractJoint homeostasis is affected by local and systemic processes. Catecholaminergic and cholinergic fibers innervate the synovium, trabecular bone, and periosteum. Several studies have investigated the involvement of the autonomic nervous system (ANS) in joint homeostasis and the pathophysiology of osteoarthritis (OA). Various resident cells of osteoarticular tissues express receptors for sympathetic and parasympathetic neurotransmitters (norepinephrine/e...
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: December 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 6Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Index
Publication date: December 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 6Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Clinical features and structured clinical evaluation of vasculitis
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): C. Ponte, A.F. Águeda, R.A. LuqmaniAbstractSystemic vasculitides are a group of heterogeneous conditions with overlapping patterns of clinical and laboratory manifestations. Moreover, clinical features can be non-specific and seemingly disparate. A major factor in defining optimal therapy and measuring treatment response is careful disease assessment targeting four main domains: activity, damage, prognosis and quality of life/function. Assessment tools such as the Birmingham Activity Score and the Vasculitis...
Source: Best Practice and Research Clinical Rheumatology - November 23, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Terence W. O'Neill, Paul S. McCabe, John McBethAbstractOsteoarthritis (OA) is the most frequent form of arthritis and a leading cause of pain and disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and spine are the most commonly affected sites. Knowledge about the occurrence and risk factors for OA is important to define the clinical and public health burden of the disease to understand mechanisms of disease occurrence and may also help to inform the development of popu...
Source: Best Practice and Research Clinical Rheumatology - November 23, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors and disease outcomes of Juvenile idiopathic arthritis
Publication date: Available online 19 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jason Palman, Stephanie Shoop-Worrall, Kimme Hyrich, Janet E. McDonaghAbstractJuvenile idiopathic arthritis (JIA) is the most common inflammatory joint condition of childhood and represents seven JIA subtypes characterised by distinct clinical and laboratory variables. Genetic and environmental factors are known to influence JIA, although many unanswered questions remain. Measurement of health outcomes in JIA is imperative for both clinical practice and research. Patient-reported outcomes present particular c...
Source: Best Practice and Research Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Genetics and pathogenesis of small-vessel vasculitis
Publication date: Available online 17 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Alan D. SalamaAbstractSmall-vessel vasculitides are uncommon autoimmune diseases characterised by inflammation and necrosis of arterioles, capillaries and venules, frequently described as various (previously eponymous) clinical syndromes. Some are associated with vessel wall immune complex deposition, whereas others are pauci-immune but paradoxically often associated with circulating anti-neutrophil cytoplasmic antibodies (ANCA). Most is known about the pathogenesis of the pauci-immune ANCA-associated syndrom...
Source: Best Practice and Research Clinical Rheumatology - November 18, 2018 Category: Rheumatology Source Type: research

Overview of changes in RMD epidemiology and outcome development in the last 10 years
Publication date: Available online 17 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Suzanne M.M. Verstappen, Loreto CarmonaAbstractEpidemiological studies have been affected by environmental (or technological and societal) changes in the last 10 years, such as the emergence of registries, big data and machine learning algorithms, epigenetics, data protection regulations or a more solid presence of the patient perspective in outcomes research. As a consequence we, epidemiologists, are facing challenges in the design, conduct, and analysis of the studies, as well as on the interpretation of th...
Source: Best Practice and Research Clinical Rheumatology - November 18, 2018 Category: Rheumatology Source Type: research

Imaging in axial spondyloarthritis: Changing concepts and thresholds
Publication date: Available online 17 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Ulrich Weber, Xenofon BaraliakosAbstractImaging is key to recognition of axial spondyloarthritis (SpA) because clinical and laboratory examinations have limited diagnostic utility. Only MRI can capture both inflammation and bone remodeling by simultaneous depiction of active and structural lesions and their anatomic location. Bone marrow edema of limited extent on the sacroiliac joint (SIJ) MRI is often nonspecific and should be interpreted along with the clinical context. Contextual interpretation of the SIJ...
Source: Best Practice and Research Clinical Rheumatology - November 18, 2018 Category: Rheumatology Source Type: research

Investigations in systemic vasculitis – The role of renal pathology
Publication date: Available online 17 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Annelies E. Berden, Maria A.C. Wester Trejo, Ingeborg M. BajemaAbstractANCA-associated vasculitis (AAV) describes a group of small-vessel vasculitides with frequent renal involvement. The first description of these conditions can be traced back to the 19th-century paper on necrotizing vasculitis by Kussmaul and Maier. Since then, our understanding of the pathogenesis has improved and the histopathological lesions have been described in detail. Characteristic histologic lesions in ANCA-associated glomeruloneph...
Source: Best Practice and Research Clinical Rheumatology - November 18, 2018 Category: Rheumatology Source Type: research