Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomography
Conclusion: Use of spectral domain optical coherence tomography was essential for the diagnosis of early-stage antimalarial toxic retinopathy in patients with the following characteristics: asymptomatic, antimalarial use 7 days a week for a period of more than 5 years, and normal clinical ophthalmologic examination.RESUMO Objetivo: Investigar a frequ ência da retinopatia tóxica em pacientes com lúpus eritematoso e artrite reumatóide com uso crônico de difosfato de cloroquina ou hidroxicloroquina, através de tomografia de coerência óptica de domínio espectral e os resultados dos exames oftalmológicos (acuidade v...
Source: Arquivos Brasileiros de Oftalmologia - January 15, 2019 Category: Opthalmology Source Type: research

Ocular abnormalities in morbid obesity
Conclusion: Morbid obesity is associated with elevated uncorrected intraocular pressure and signs of neuropathy and retinopathy. Obesity may thus increase the risks of glaucoma and glaucomatous optic neuropathy.RESUMO Objetivo: A obesidade est á associada a doenças oulares, mas as mudanças estruturais subjacentes e os mecanismos patogênicos não foram examinados detalhadamente. Aqui avaliamos os efeitos da obesidade mórbida nos índices morfométricos da doença ocular. Métodos: Voluntários obesos mórbidos (n=101, índice de mass a corporal ³40) e indivíduos saudáveis (n=95, índice de massa corporal 18,50 a 2...
Source: Arquivos Brasileiros de Oftalmologia - January 15, 2019 Category: Opthalmology Source Type: research

Correlation between pathogenic species and clinical findings, disease severity, and visual outcome in patients with fungal keratitis
Conclusion: Fusarium sp. was predominant in patients aged £50 years and those with a recent history of foreign body and/or ocular trauma, whereas Candida sp. was predominant in older adults, in those with a postoperative ocular surgery, in those with a previous ocular pathology, and in immunodepressed patients.RESUMO Objetivo: Determinar se existe uma correla ção entre espécies patogênicas e achados clínicos, gravidade da doença e resultado visual em pacientes com ceratite e crescimento de fungos em cultura microbiológica. Métodos: Estudo retrospectivo de pacientes com crescimento de fungos na cultura microbio...
Source: Arquivos Brasileiros de Oftalmologia - January 15, 2019 Category: Opthalmology Source Type: research

How to choose and conduct a research project: some advice for young investigators
(Source: Arquivos Brasileiros de Oftalmologia)
Source: Arquivos Brasileiros de Oftalmologia - January 15, 2019 Category: Opthalmology Source Type: research

Trends in corneal transplantation from 2001 to 2016 in Brazil
ABSTRACT A retrospective and analytical study was conducted by using data from the National Transplantation System on 184,575 corneal transplantations performed between January 2001 and December 2016 in order to analyze thetrends in corneal transplantation from 2001 to 2016 in Brazil. The Cochran-Armitage test, analysis of variance, and Duncan ’ s multiple comparisons were used to verify the existence of trends, compare the mean values between regions, and verify the mean differences, respectively. A significance level of 5% was used for all tests. The analysis showed that there was a 2.4-fold increase in the number of c...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research

Morphological and functional findings in Alström syndrome: a study of two families
This study describes the retinal structure and functional aspects of four patients (8 eyes) from two different families as determined by optical coherence tomography (OCT), fu ndus autofluorescence, and full-field electroretinography. There was a correlation between morphological and functional findings, evidenced by typical funduscopic changes of retinal dystrophy in spectral domain-OCT and electrophysiological analyses. Foveal characteristics include a single layer of u ndifferentiated photoreceptors with retinal disorganization mainly from external segments, in agreement with previous reports in the literature. Fundus a...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research

Trichothiodystrophy: a case report of childhood glaucoma associated with non-acquired systemic disease
We report a case of childhood glaucoma in a patient with trichothiodystrophy who underwent trabeculectomy in the left eye. To our knowledge, this is the first clinical report of childhood glaucoma associated with trichothiodystrophy.RESUMO A tricotiodistrofia pertence a um grupo de doen ças genéticas raras caracterizadas por anomalias da reparação do DNA. Manifestações oculares podem ocorrer em 50% dos casos, incluindo catarata, erros refrativos, estrabismo, microcórnea, microftalmia, olho seco e alterações maculares pigmentares. Relatamos um caso de glaucoma infantil em u m paciente com tricotiodistrofia submetid...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research

Metastatic choroidal melanoma to the contralateral eye: a rare case
ABSTRACT Uveal melanoma is the most common adult primary intraocular cancer. Although liver metastasis is common to the natural history of the disease, metastasis to the fellow eye is extremely rare. Here we report the case of a 59-year-old man with choroidal melanoma in his right eye who underwent enucleation at a different center. The patient was referred to our service 21 months postoperatively, complaining of decreased vision. He was found to have a new pigmented choroidal tumor in his left eye associated with liver disease. Ocular ultrasonography and liver biopsy with histopathological and immunohistochemical analysis...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research

Complication of micro-bypass stenting: the anterior chamber displacement of a Xen implant
ABSTRACT Although minimally invasive glaucoma surgery using different types of implants is a promising strategy for treating glaucoma, potential long-term complications require further evaluation. Here, we report a case of the anterior chamber displacement of a Xen implant due to a maneuver aimed at correcting a dysfunctional and bent subconjunctival implant.RESUMO Embora a cirurgia de glaucoma minimamente in vasiva, que usa diferentes tipos de implantes, seja uma estrat égia promissora para o tratamento do glaucoma, as possíveis complicações a longo prazo exigem uma avaliação mais aprofundada. Aqui, relatamos um cas...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research

Ocular delivery of moxifloxacin-loaded liposomes
Conclusions: The in vivo experiments resulted in liposomes containing moxifloxacin that were homogenous in size and exhibited high drug encapsulation efficien cy. The results indicate that liposomes containing moxifloxacin offers a satisfactory aqueous humor release profile after intracameral application.RESUMO Objetivo: Determinar o perfil de libera ção, no humor aquoso, de moxifloxacino encapsulado em lipossomas como um sistema de liberação controlada para aplicação intracameral. Métodos: Lipossomas contendo moxifloxacino foram obtidos através do método de hidratação do filme lipídico e caracterizados por t...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research

Effect of the bioprotectant agent trehalose on corneal epithelial healing after corneal cross-linking for keratoconus
Conclusion: The application of eye drops containing the combination of trehalose and sodium hyaluronate resulted in faster corneal re-epithelialization following corneal cross-linking than that of eye drops containing sodium hyaluronate alone .RESUMO Objetivo: Este estudo teve como objetivo comparar a efic ácia de colírios contendo uma combinação de hialurônico de sódio e hialuronato de sódio e trealose para o tratamento da cicatrização epitelial em pacientes com cross-linking corneano. Métodos: Este estudo inclui 46 olhos de 23 pacientes com ceratocone, que foram operados com cross-linking corneano em ambos o...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research

The outcomes of 326 external dacryocystorhinostomy operations in children with dacryostenosis - 30-year experience of an oculoplastic surgeon
Conclusions: External dacryocystorhinostomy in children has a high success rate if performed by an experienced oculo plastic surgeon.RESUMO Objetivo: Relatar as caracter ísticas demográficas e os resultados cirúrgicos em 320 crianças submetidas à dacriocistorrinostomia externa para dacrioestenose. Métodos: Foi realizada uma avaliaçãodos prontuários de pacientes com idade<16 anos submetidos à cirurgia de dacriocistorrinostomia externa. Características demográficas do paciente e taxa de sucesso das operações foram analisadas a partir dos registros de dados. Crianças com menos de 12 meses de acompanhamento...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research

Evaluation of renin and angiotensin II levels in pseudoexfoliation syndrome
Conclusion: Aqueous humor renin levels are higher in pseudoexfoliation syndrome. The results indicate a probable role of renin-angiotensin system in pseudoexfoliation syndrome. Further studies with larger numbers of cases are neede d to clarify the precise association of renin-angiotensin system with the etiopathogenesis of pseudoexfoliation syndrome.RESUMO Objetivo: A s índrome de pseudo-exfoliação tem sido associada ao comprometimento da função do coração e dos vasos sanguíneos. Foi realizado um estudo para investigar o papel do sistema renina-angiotensina na etiopatogenia da síndrome de pseudo-exfoliação. M...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research

The relationship between topical anti-glaucoma medications and the development of lacrimal drainage system obstruction
Conclusion: No single topical anti-glaucoma medication demonstrated a stronger association with the development of lacrimal duct obstruction.RESUMO Objetivo: Avaliar se algum medicamento t ópico anti-glaucoma aumenta o risco de obstrução do sistema de drenagem lacrimal ou se a presença de conservantes é su fi cien te para gerar obstrução. Métodos: Este estudo de caso-controle aninhado comparou um grupo de pacientes com obstrução do ducto lacrimal que receberam medicações tópicas anti-glaucoma contra um grupo controle de pacientes sem obstrução. Resultados: Foram revistos os prontuários de 255 pacientes c...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research

Impact of environmental pollution on the ocular surface of Sjögren’s syndrome patients
Conclusions: Here we demonstrated that in patients with dry eye syndrome associated with Sj ögren, abnormalities of the ocular surface and eye irritation related to air pollution are more severe than those in the control group. We believe that measuring air quality should be not only an integral part of the evaluation of ocular surface disease but also a therapeutic consideration.RESUMO Objetivo: Avaliar o efeito da polui ção do ar na superfície ocular de pacientes com síndrome de Sjögren. Métodos: Foram investigadas as superfícies oculares de trinta pacientes com síndrome de Sjögren e trinta voluntários saudÃ...
Source: Arquivos Brasileiros de Oftalmologia - October 18, 2018 Category: Opthalmology Source Type: research