Development and usefulness of an instrument for the standard description and comparison of services for disabilities (DESDE).
CONCLUSION: DESDE is a useful and reliable instrument for the assessment of services for persons with disabilities. PMID: 17087812 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Cost-effectiveness of different clinical interventions for reducing the burden of schizophrenia in Spain.
CONCLUSION: The relatively modest additional cost of concurrent psychosocial treatment has significant health gains, thereby making such a combined strategy for schizophrenia more cost-effective than pharmacology alone. PMID: 17087813 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Cost-utility of selective serotonin reuptake inhibitors for depression in primary care in Catalonia.
CONCLUSION: Fluoxetine seems to be a better cost-utility SSRI option for treating depressive disorders in PC. PMID: 17087814 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Melancholia: Beyond DSM, Beyond Neurotransmitters. Proceedings of a conference, May 2006, Copenhagen, Denmark.
Authors: PMID: 17280564 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

The doctrine of the two depressions in historical perspective.
CONCLUSION: The concept of 'major depression' popularized in DSM-III in 1980 is a historical anomaly. It mixes together psychopathologic entities that previous generations of experienced clinicians and thoughtful nosologists had been at pains to keep separate. Recently, there has been a tendency to return to the concept of two depressions: melancholic and non-melancholic illness. 'Major depression' is coming into increasing disfavor. In the next edition of DSM (DSM-V), major depression should be abolished; melancholic mood disorder (MMD) and non-melancholic mood disorder (NMMD) should become two of the principle entities i...
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Resurrecting melancholia.
CONCLUSION: The review supports the establishment of melancholia by empirically derived criteria rather than by a checklist is an alternative to the major depression choice and offers an improved model for psychiatric classification. PMID: 17280566 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Defining melancholia: the primacy of psychomotor disturbance.
CONCLUSION: Melancholia is positioned as a categorical entity capable of being circumscribed by its cardinal feature of PMD. PMID: 17280567 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

The facets of melancholia.
CONCLUSION: A diagnosis of melancholia may eventually prove valuable in treatment selection, but the necessary evidence will not be forthcoming until a widely accepted definition exists that is both inherently valid and that can be applied consistently across research sites. PMID: 17280568 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

The incidence and prevalence of manic-melancholic syndromes in North West Wales: 1875-2005.
CONCLUSION: There are some grounds for revisiting the concept of manic-melancholic disorder put forward by Rafaelsen. The changes in the incidence of postpartum psychoses may have a wider significance for the affective disorders in general. PMID: 17280569 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

A mixed state core for melancholia: an exploration in history, art and clinical science.
CONCLUSION: These findings and considerations overall do suggest that melancholia as defined today is more closely aligned with the depressive and/or mixed phase of bipolar disorder. Given the high suicidality from many of these patients the practice of treating them with antidepressant monotherapy needs re-evaluation. PMID: 17280570 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Melancholia agitata and mixed depression.
CONCLUSION: Psychic and motor agitation are considered equally important for the definition of agitated depression. Treating agitated depression with antidepressants worsens the clinical picture. The use of Electroconvulsive Therapy (ECT), neuroleptics and anticonvulsants are recommended. The term Melancholia Agitata is proposed for agitated (mixed) depression. PMID: 17280571 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Atypical depression: current status and relevance to melancholia.
CONCLUSION: DSM-IV criteria for depression with atypical features define a valid, but heterogeneous disorder. Criteria including age of onset and chronicity may define a more homogeneous group that is distinct from both melancholia and other depressed patients. PMID: 17280572 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Melancholia and atypical depression in the Zurich study: epidemiology, clinical characteristics, course, comorbidity and personality.
CONCLUSION: Melancholic MDE was more severe than atypical MDE although the two groups shared many characteristics. The longitudinal overlap of melancholia with atypical depression in almost half of all cases calls for comparative analyses of combined, pure and unspecified MDE. PMID: 17280573 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Epidemiology of subtypes of depression.
CONCLUSION: Further longitudinal, analytical, and genetic epidemiologic studies are needed to reveal which conditions are mild and transient, and which may be precursors of more severe and substantial illness such as melancholia. PMID: 17280574 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Pathophysiology of hypercortisolism in depression.
CONCLUSION: Increased ACTH secretion occurs in depressed in-patients regardless of cortisolemic status, confirming central HPA axis overdrive in severe depression. Depressive hypercortisolemia results from an additional change in the adrenal cortex that causes ACTH-independent, disorderly basal cortisol release, a sign of physiological stress in melancholic/psychotic depression. PMID: 17280575 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research