Pathophysiology of hypercortisolism in depression.

CONCLUSION: Increased ACTH secretion occurs in depressed in-patients regardless of cortisolemic status, confirming central HPA axis overdrive in severe depression. Depressive hypercortisolemia results from an additional change in the adrenal cortex that causes ACTH-independent, disorderly basal cortisol release, a sign of physiological stress in melancholic/psychotic depression. PMID: 17280575 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/PubMed/17280575?dopt=Abstract

Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

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