Neuropharmacological basis of combining antidepressants.
CONCLUSION: Unfortunately, there are still, as yet, insufficient data to categorically justify choosing one or other combination based only on the neuropharmacological evidence. PMID: 16307615 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Potentiation strategies for treatment-resistant depression.
CONCLUSION: Several pharmacological potentiation strategies exist. Whilst good evidence exists for lithium combined with antidepressants, although good results have also been reported with augmentation strategies involving T3 or buspirone. PMID: 16307616 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Combined antidepressants: clinical experience.
CONCLUSION: Adding or combining antidepressant medications has advantages for the speed of onset and maintaining the existing response. More rigorous clinical trials comparing combination therapy with monotherapy and for the development of rational treatment guidelines are required. PMID: 16307617 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Use of antidepressant combinations: which, when and why? Results of a Spanish survey.
CONCLUSION: Antidepressant combinations are frequently used in clinical practice. Pharmacological profiles are always considered and SSRIs + mirtazapine is the option usually chosen. PMID: 16307618 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Patients with severe mental illness: a most difficult-to-treat patient population. Proceedings of a conference on clinical and social psychiatry, 23-27 September 2003, Zurich, Switzerland.
Authors: PMID: 16445475 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Psychiatric services for people with severe mental illness across western Europe: what can be generalized from current knowledge about differences in provision, costs and outcomes of mental health care?
CONCLUSION: It is conceivable that the principal targets of mental healthcare reform can be achieved along several pathways taking into account economic, political and sociocultural variation between countries. Differences between mental healthcare systems appear to affect service provision and costs. However, the impact of such differences on patient outcomes may be less marked. The empirical evidence is limited and further studies are required. PMID: 16445476 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Severe mental illness across cultures.
CONCLUSION: Severe mental illness is as likely to be affected by culture as other illnesses. Clinicians need to use multi-model assessment and management techniques. PMID: 16445477 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Heavy use of acute in-patient psychiatric services: the challenge to translate a utilization pattern into service provision.
CONCLUSION: Specific preventive interventions to contain heavy service use seem to be out of reach for the majority of high utilizing patients. However, services that have proven effective in reducing admissions to in-patient treatment and length of stay may nevertheless help to reduce heavy service use. PMID: 16445478 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

De-constructing home-based care for mental illness: can one identify the effective ingredients?
CONCLUSIONS: It is premature to define an optimal configuration for home based care services. The need for introducing differing components of such care will depend on what is currently available locally. Where regular home visiting to psychotic patients plus a broad service model incorporating health and social care objectives are provided, major reductions in in-patient care are not currently to be anticipated by service re-configurations. PMID: 16445479 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Intervention effects of supplying homeless individuals with permanent housing: a 3-year prospective study.
CONCLUSION: The placement of homeless individuals in board and care homes or community housing after social counselling seems to be a necessary measure to remedy homelessness. However, supplying more permanent housing is not sufficient to decisively improve mental health status. PMID: 16445480 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

The relationship between mental illness severity and stigma.
CONCLUSION: Beside perceived treatment intensity and diagnostic label, the perception of social disability of mentally ill people accounts for a differentiated stigma. The question arises how anti-stigma-programmes can include the topic of social disability into their messages without risking to strengthen the stigma of mental illness. PMID: 16445481 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Determinants of quality of life in people with severe mental illness.
CONCLUSION: Efforts to improve subjective quality of life in people with severe mental illness should include a careful monitoring of depressive and anxiety symptoms, and pay particular attention to assessment of and interventions against unmet needs. Further, such interventions should stress a strengthening of the social support of the clients. It is also important to pay attention to mediators of changes in subjective quality of life such as self-esteem, mastery, autonomy, and self-efficacy. PMID: 16445482 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Do mental health professionals stigmatize their patients?
CONCLUSION: Mental health professionals must improve their attitudes towards people with mental illness. Different ways, e.g. improving their professional education or their quality of professional contacts by regular supervision to prevent burn-out, are discussed. PMID: 16445483 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Family burden and social network in schizophrenia vs. physical diseases: preliminary results from an Italian national study.
CONCLUSION: These results highlight the need to provide families of those with long-term diseases with supportive interventions, aiming to: i) manage relatives' psychological reactions to patient's illness; ii) provide information on patient's disease; iii) reinforce relatives' social network, especially in the case of schizophrenia. PMID: 16445484 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research

Severe mental illness in depression.
CONCLUSION: Considering that persisting depressive symptoms are associated with a range of unfavourable outcomes, the present data point to a serious problem in the treatment of MDD and the urgent need to further optimize antidepressive treatment strategies. PMID: 16445485 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)
Source: Acta Psychiatrica Scandinavica Supplementum - March 9, 2013 Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research