Comparison of the effect of negative pressure wound therapy with and without installation of polyhexanide on the bacterial kinetic in chronic wounds
Conclusion It was demonstrated that management of infected wounds with NPWT, with or without instillation of 0.02% PHMB, did not reduce the number of bacteria on wounds. Bacteria proliferate below a NPWT dressing and increase in numbers. Independently of bacterial kinetics, all wounds showed excellent granulation and healed with no complications. This observation challenges the concept that bacterial bioburden correlates with impaired wound healing. [Vergleichende Untersuchung des Effektes der Unterdruck-Wundtherapie mit und ohne Instillation von Polyhexanid auf die bakterielle Kinetik in chronischen Wunden] (Source: Wound Medicine)
Source: Wound Medicine - February 23, 2016 Category: Journals (General) Source Type: research
Effects of EGF on apoptosis of adipose derived stem cells by regulating miRNA-21
CONCLUSION Our results indicated that miR-21 could influence EGF expression and furtherly inhibits the apoptosis of ADSCs by downregulating PTEN and FASL. These findings may provide clues towards regulating biological activity of ADSCs with miR-21. (Source: Wound Medicine)
Source: Wound Medicine - February 23, 2016 Category: Journals (General) Source Type: research
Effect of topical mixture of honey, royal jelly and olive oil-propolis extract on skin wound healing in diabetic rats
Conclusion The results showed that Nika cream accelerate the wound healing in normal and diabetic subjects. (Source: Wound Medicine)
Source: Wound Medicine - December 11, 2015 Category: Journals (General) Source Type: research
Synthesize of Titanium dioxide nanoparticles using Moringa oleifera leaves and evaluation of wound healing activity
Publication date: Available online 23 November 2015 Source:Wound Medicine Author(s): V. Sivaranjani, P. Philominathan Titanium dioxide nanoparticles(TiNPs) were emerged as wound healing enhancer as well as an antibacterial agent against Gram-positive and Gram-negative bacteria due to its enhanced mechanical properties. Moreover, the green synthesized Titanium dioxide exhibited significant wound healing activity in Albino rats which was confirmed by measuring wound closure. Titanium dioxide nanoparticles were effectively synthesized using aqueous leaf extract of Moringa oleifera under pH and temperature dependent co...
Source: Wound Medicine - November 23, 2015 Category: Journals (General) Source Type: research
In vitro evaluation of acellular porcine urinary bladder extracellular matrix – A potential scaffold in tissue engineered skin
This study demonstrates that UBM fulfils the fundamental properties for scaffold design and is a promising novel scaffold for future skin tissue engineering efforts. (Source: Wound Medicine)
Source: Wound Medicine - November 21, 2015 Category: Journals (General) Source Type: research
In vitro evaluation of acellular porcine urinary bladder extracellular matrix–a potential scaffold in tissue engineered skin.
This study demonstrates that UBM fulfils the fundamental properties for scaffold design and is a promising novel scaffold for future skin tissue engineering efforts. (Source: Wound Medicine)
Source: Wound Medicine - November 17, 2015 Category: Journals (General) Source Type: research
First results of a new hyperspectral camera system for chemical based wound analysis
We present the first hyperspectral camera for quick and robust acquisition of hyperspectral data in the combined VIS and NIR spectral range with high spectral and spatial resolution from wounds. First case studies and evaluations of chemometric parameters like the oxygenation of hemoglobin and perfusion quality are presented and exhibit the high quality and potential of this new wound measurement system. (Source: Wound Medicine)
Source: Wound Medicine - November 12, 2015 Category: Journals (General) Source Type: research
Porcine cholecyst derived extracellular matrix (p-CEM) for reconstruction of full thickness skin wounds in rats
Publication date: Available online 12 November 2015 Source:Wound Medicine Author(s): Poonam Shakya, A.K. Sharma, Naveen Kumar, V. Remya, Dayamon D. Mathew, Prasoon Dubey, Kiranjeet Singh, Sonal, Sameer Shrivastava, S.K. Maiti, Anwarul Hasan, K.P. Singh An acellular cholecyst derived extracellular matrix (p-CEM) of porcine origin was prepared using anionic biological detergent. Healing potential of (p-CEM) was compared with commercially available collagen sheet (b-CS) and open wound (C) in full-thickness skin wounds in rats. Thirty six clinically healthy adult Sprague Dawley rats of either sex w...
Source: Wound Medicine - November 12, 2015 Category: Journals (General) Source Type: research
Effect of adipose derived nucleated cell fractions with chitosan biodegradable film on wound healing in rats
In this study the effect of combination of adipose derived nucleated cell fractions (ADNCs) and chitosan film was evaluated on full thickness wounds. For excisional wound healing model twenty-four male white Wistar rats were randomized into four groups of 6 rats each: Control group (CG) including creation of wounds and no treatment, ADNC group including creation of wounds and application of one milliliter ADNCs, Chitosan group (CHIT) including dressing the wound with chitosan and CHIT/ADNC group including application of one mL ADNCs and dressing the wound with chitosan. Wound size was measured on 6, 9, 12, 15, 18 and 21day...
Source: Wound Medicine - September 25, 2015 Category: Journals (General) Source Type: research
Consensus document on electrical stimulation in treatment of chronic wounds in preparation for a national S1 Guideline
Publication date: Available online 11 September 2015 Source:Wound Medicine Author(s): K. Herberger, K. Heyer, L. Goepel, H. Diener, J. Dissemond, K. Baade, E.S. Debus, H. Lawall, K. Protz, T. Wild, M. Augustin (Source: Wound Medicine)
Source: Wound Medicine - September 12, 2015 Category: Journals (General) Source Type: research
The effects of bromelain on angiogenesis, nitric oxide, and matrix metalloproteinase-3 and -9 in rats exposed to electrical burn injury
This study was aimed to investigate the effects of bromelain on angiogenesis, nitric oxide, and matrix metalloproteinase-3 and -9 in rats exposed to 1200 millivoltage electrical burn injury. Thirty five, male Wistar albino rats was divided into five groups (n=7 each), including control (untreated) group; electrical burn injury (EI) group; electrical burn injury+21.25mg/kg body weight bromelain group (EIB1); electrical burn injury+42.50mg/kg body weight bromelain group (EIB2); and electrical burn injury+85.00mg/kg body weight bromelain group (EIB3). Rat models of electrical burns done by providing electricity in rats that h...
Source: Wound Medicine - September 4, 2015 Category: Journals (General) Source Type: research
The German national consensus on wound documentation and outcomes: Rationale, working programme and current status
Conclusions Based on a national joint process involving medical societies, nursing groups, German sickness funds and health politics, a continuous decision process on standards for outcomes measurement and interpretation could be established. The Delphi based decision processes showed high levels of participations, thus providing a valid and robust set of standards. First results are in process of approval by the societies. (Source: Wound Medicine)
Source: Wound Medicine - May 5, 2015 Category: Journals (General) Source Type: research
In vitro study on endotoxin release of gram-negative bacteria after contact with silver releasing compared to DACC coated wound dressings
Publication date: December 2014 Source:Wound Medicine, Volume 7 Author(s): Horst Braunwarth , Dietmar Becher , Florian H.H. Brill The treatment of critically colonised or locally infected wounds with local antimicrobial agents is a standard of care. The destruction of especially gram-negative bacteria potentially increases the endotoxin level in the wound. This in vitro study aims to answer the question of whether and to what extent endotoxin release caused by the destruction of gram-negative bacteria is influenced by different wound dressing. Silver ion releasing dressings were compared to wound dressings with hydr...
Source: Wound Medicine - April 29, 2015 Category: Journals (General) Source Type: research
Prospective Randomize-Controlled Comparison between Silicone plus Herbal Extract Gel versus Aloe vera Gel for Burn Scar Prophylaxis
In conclusion, the silicone plus herbal extract gel appears to be superior to Aloe vera gel in prevention of hypertrophic scars formation. (Source: Wound Medicine)
Source: Wound Medicine - April 25, 2015 Category: Journals (General) Source Type: research
Oxidative stress and inflammation associated with decreased fibrinolysis as an early marker for peripheral vascular disease stratification: A clinical study
Discussion A decreased inflammatory component with increased oxidative stress is more likely to lead to calcification of the arteries and a higher ABPI, despite normal BGL, HbA1c and cholesterol profile. Our study shows that emerging biomarkers provide a sound basis for differentiating pathophysiological processes associated with low and high ABPI. Traditional biomarkers showed a high accuracy for identification of low ABPI in our model but failed to do better than chance for identification of high ABPI, suggesting different pathophysiological pathways that include oxidative stress and inflammatory components. Clinically, ...
Source: Wound Medicine - April 25, 2015 Category: Journals (General) Source Type: research
