Oxidative stress and inflammation associated with decreased fibrinolysis as an early marker for peripheral vascular disease stratification: A clinical study

Discussion A decreased inflammatory component with increased oxidative stress is more likely to lead to calcification of the arteries and a higher ABPI, despite normal BGL, HbA1c and cholesterol profile. Our study shows that emerging biomarkers provide a sound basis for differentiating pathophysiological processes associated with low and high ABPI. Traditional biomarkers showed a high accuracy for identification of low ABPI in our model but failed to do better than chance for identification of high ABPI, suggesting different pathophysiological pathways that include oxidative stress and inflammatory components. Clinically, validation of novel and more comprehensive risk factors for PVD sheds light on the etiology of the disease and mechanics of progression towards better preventative care, early detection and targeted drug delivery.
Source: Wound Medicine - Category: Journals (General) Source Type: research