A systematic review of the use of rituximab for the treatment of antibody-mediated renal transplant rejection
Rituximab is a B-lymphocyte depleting agent that is used to treat hematological malignancies and autoimmune diseases. Recently, it has gained interest as an immunomodulatory agent in renal transplantation. This systematic review evaluates the evidence for its use in the treatment of acute and chronic antibody-mediated renal transplant rejection (AAMR; CAMR). A systematic search of four databases and three trial registries was conducted. The small number and heterogeneous nature of included studies precluded meta-analysis and thus a narrative review was conducted. (Source: Transplantation Reviews)
Source: Transplantation Reviews - January 22, 2017 Category: Transplant Surgery Authors: Philip S Macklin, Peter J Morris, Simon R Knight Source Type: research
Kidney Paired Exchange and Desensitization: Strategies to Transplant the Difficult to Match Kidney Patients with Living Donors
With organs in short supply, only a limited number of kidney transplants can be performed a year. Live donor donation accounts for 1/3rd of all kidney transplants performed in the United States. Unfortunately, not every donor recipient pair is feasible because of Human leukocyte antigen (HLA sensitization and ABO incompatibility. To overcome these barriers to transplant, strategies such as kidney paired donation (KPD) and desensitization have been developed. KPD is the exchange of donors between at least two incompatible donor-recipient pairs such that they are now compatible. (Source: Transplantation Reviews)
Source: Transplantation Reviews - January 22, 2017 Category: Transplant Surgery Authors: Thomas A. Pham, Jacqueline I. Lee, Marc L. Melcher Source Type: research
Immunomodulation by hyperimmunoglobulins after solid organ transplantation: beyond prevention of viral infection
Hyperimmunoglobulins are pharmaceutical formulations of human IgG which contain high titres of antibodies against specific viruses. They have been successfully used in solid organ transplantation (SOT) to prevent Cytomegalovirus (CMV) and Hepatitis B Virus (HBV) infection. The introduction of effective and cheaper antiviral drugs has resulted in decreasing usage of hyperimmunoglobulins in SOT. However, it may still be attractive to combine antiviral drug therapy with hyperimmunoglobulins after SOT, as there is some evidence that hyperimmunoglobulins, similar to high doses of intravenous immunoglobulins (IVIg), might exert ...
Source: Transplantation Reviews - January 17, 2017 Category: Transplant Surgery Authors: Rogier van Gent, Herold J. Metselaar, Jaap Kwekkeboom Source Type: research
Management of the Obese Kidney Transplant Candidate
Obesity is an increasingly common condition that can exclude end stage renal disease patients from consideration of kidney transplantation. The optimal management of obese transplant candidates is uncertain, especially the use of pharmacologic therapies or bariatric surgery. We review the rationale to consider transplantation in obese patients, the impact of obesity on access to kidney transplantation, the evidence for obese patients to lose weight loss prior to kidney transplantation, perioperative management considerations and specific weight loss strategies prior to transplantation. (Source: Transplantation Reviews)
Source: Transplantation Reviews - January 12, 2017 Category: Transplant Surgery Authors: Julie Lesage, John S. Gill Source Type: research
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Source: Transplantation Reviews - December 31, 2016 Category: Transplant Surgery Source Type: research
Editorial Board
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Source: Transplantation Reviews - December 31, 2016 Category: Transplant Surgery Source Type: research
Table of Contents
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Source: Transplantation Reviews - December 31, 2016 Category: Transplant Surgery Source Type: research
Instructions for Authors
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Source: Transplantation Reviews - December 31, 2016 Category: Transplant Surgery Source Type: research
Acknowledgement
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Source: Transplantation Reviews - December 31, 2016 Category: Transplant Surgery Authors: Editors Transplantation Reviews Source Type: research
Epstein –Barr virus and renal transplantation
Epstein –Barr virus (EBV) is a gamma herpesvirus associated with diseases ranging from asymptomatic viremia to post-transplant malignancies in kidney transplant recipients. EBV specifically is associated with post-transplantation lymphoproliferative disorder (PTLD), in kidney transplant recipients, with i ncreased risk in EBV seronegative patients with EBV seropositive donors on intensified immunosuppression. The diagnosis of PTLD relies on clinical suspicion plus tissue biopsy with polymerase chain reaction (PCR) testing of blood currently used for risk determination in high-risk recipients. (Source: Transplantation Reviews)
Source: Transplantation Reviews - December 29, 2016 Category: Transplant Surgery Authors: Jade Le, Christine M. Durand, Irfan Agha, Daniel C. Brennan Source Type: research
Epstein-Barr Virus and Renal Transplantation
Epstein-Barr virus (EBV1) is a gamma herpesvirus associated with diseases ranging from asymptomatic viremia to post-transplant malignancies in kidney transplant recipients. EBV specifically is associated with post-transplantation lymphoproliferative disorder (PTLD2), in kidney transplant recipients, with increased risk in EBV seronegative patients with EBV seropositive donors on intensified immunosuppression. The diagnosis of PTLD relies on clinical suspicion plus tissue biopsy with polymerase chain reaction (PCR3) testing of blood currently used for risk determination in high-risk recipients. (Source: Transplantation Reviews)
Source: Transplantation Reviews - December 29, 2016 Category: Transplant Surgery Authors: Jade Le, Christine Durand, Irfan Agha, Daniel C. Brennan Source Type: research
Graft inflow modulation in adult-to-adult living donor liver transplantation: a systematic review
Small-for-size syndrome (SFSS) has an incidence between 0 and 43% in small-for-size graft (SFSG) adult living donor liver transplantation (LDLT). Portal hypertension following reperfusion and the hyperdynamic splanchnic state are reported as the major triggering factors of SFSS. Intra- and postoperative strategies to prevent or to reduce its onset are still under debate.We analyzed graft inflow modulation (GIM) during adult LDLT considering the indications, efficacy of the available techniques, changes in hemodynamics and outcomes. (Source: Transplantation Reviews)
Source: Transplantation Reviews - December 6, 2016 Category: Transplant Surgery Authors: Roberto I. Troisi, Giammauro Berardi, Federico Tomassini, Mauricio Sainz-Barriga Source Type: research
Prevention and Management of Lymphocele Formation Following Kidney Transplantation
Despite preventive methods, lymphoceles frequently form following kidney transplantation (KTx), with an incidence of 0.6% –51%. Here, we summarize the current strategies for preventing and managing this complication, and describe the approach used in our department. Rapid diagnosis and early treatment of lymphoceles through a well-defined approach can prevent or reduce the risk of organ loss. Diagnosis can be made by ultrasound, computed tomography, or magnetic resonance imaging and laparoscopic fenestration is the current therapy of choice when non-surgical methods fail. (Source: Transplantation Reviews)
Source: Transplantation Reviews - November 15, 2016 Category: Transplant Surgery Authors: Mohammad Golriz, Miriam Klauss, Martin Zeier, Arianeb Mehrabi Source Type: research
Steering between Scylla and Charybdis: Picking out the optimum time of Double-J stent removal following renal transplantation
Worldwide, the usefulness of stenting the ureterovesical anastomosis during renal transplantation was a debatable issue among renal transplant surgeons. Even more debatable is the appropriate post-transplant time-point to remove the Double-J stent (DJS), since stenting is efficient in securing ureterovesical anastomosis for early post-transplant urological complications but could also be a nidus for symptomatic urinary tract infections (UTI), especially in immunosuppressed patients. According to our view, the optimal time for stent removal is like being between Scylla and Charybdis, which is an idiom deriving from Greek my...
Source: Transplantation Reviews - November 2, 2016 Category: Transplant Surgery Authors: Chrysoula Argyrou, Demetrios Moris, Spiridon Vernadakis Source Type: research
The role of arterial conduits for revascularisation in adult orthotopic liver transplantation
The successful outcome in orthotopic liver transplantation (OLT) is critically dependent on the uncompromised hepatic graft blood inflow. Arterial conduits represent a good solution in cases where conventional revascularisation is not possible. The purpose of this systematic review is to analyse the published evidence on the use of arterial conduits in adult OLT. After review of the Pubmed and EMBASE databases, 19 relevant studies were identified and analysed.Even though patient survival was comparable, most large studies reported worse 1-, 3- and 5-year graft survival rates compared to grafts with standard arterial revasc...
Source: Transplantation Reviews - November 2, 2016 Category: Transplant Surgery Authors: Nikolaos A. Chatzizacharias, Mohamed Aly, Raaj K. Praseedom Source Type: research
