Epstein-Barr Virus and Renal Transplantation

Epstein-Barr virus (EBV1) is a gamma herpesvirus associated with diseases ranging from asymptomatic viremia to post-transplant malignancies in kidney transplant recipients. EBV specifically is associated with post-transplantation lymphoproliferative disorder (PTLD2), in kidney transplant recipients, with increased risk in EBV seronegative patients with EBV seropositive donors on intensified immunosuppression. The diagnosis of PTLD relies on clinical suspicion plus tissue biopsy with polymerase chain reaction (PCR3) testing of blood currently used for risk determination in high-risk recipients.
Source: Transplantation Reviews - Category: Transplant Surgery Authors: Source Type: research