Measuring alloreactivity and drug adherence: Making the best of what we have
Expanding knowledge of alloimmune response mechanisms and development of novel, more potent and selective immunosuppressive agents have not translated yet into significant improvements in long-term graft survival [1]. Enthusiasm toward implementation of sophisticated therapies is frustrated by the lack of tools to monitor alloimmunity and titrate immunosuppression. As a result, immunosuppressive treatment is still guided by insensitive and/or unspecific measures such as serum creatinine, therapeutic drug monitoring, and kidney biopsies. (Source: Transplantation Reviews)
Source: Transplantation Reviews - February 20, 2015 Category: Transplant Surgery Authors: Umberto Maggiore Source Type: research
Antidiabetic Therapy in Post Kidney Transplantation Diabetes Mellitus
Post-transplantation diabetes mellitus (PTDM) is a common complication after kidney transplantation that affects up to 40 % of kidney transplant recipients. By pathogenesis, PTDM is a diabetes form of its own, and may be characterized by a sudden, drug-induced deficiency in insulin secretion rather than worsening of insulin resistance over time. In the context of deteriorating allograft function leading to a re-occurrence of chronic kidney disease after transplantation, pharmacological interventions in PTDM patients deserve special attention. (Source: Transplantation Reviews)
Source: Transplantation Reviews - January 13, 2015 Category: Transplant Surgery Authors: Johannes Werzowa, Marcus Säemann, Michael Haidinger, Michael Krebs, Manfred Hecking Source Type: research
Intra-Patient Variability in Tacrolimus Exposure: Causes, Consequences for Clinical Management
Tacrolimus (Tac) is widely used for the prevention of rejection after solid organ transplantation. Finding the optimal balance between effective Tac concentrations and toxicity is a challenge and requires therapeutic drug monitoring. In addition to the well-known inter-patient variability, the clinical use of Tac is also complicated by considerable intra-patient variability (IPV) in Tac exposure. Tac IPV is defined as the amount of fluctuation of whole-blood concentrations over a certain period of time during which the Tac dose remains unchanged. (Source: Transplantation Reviews)
Source: Transplantation Reviews - January 13, 2015 Category: Transplant Surgery Authors: Nauras Shuker, Teun van Gelder, Dennis A. Hesselink Source Type: research
Circulating Biomarkers of Tolerance
On the basis of reviewed literature here we describe models of tolerance and summarize the evidence of circulating biomarkers suitable for the assessment of immunological risk in organ transplantation.We focused on results of evaluation of specific peripheral immune cell populations and transcripts in peripheral blood of operationally tolerant liver and kidney transplant recipients. Validation of described markers to define potentially tolerant patients before their use in clinical trials is critical. (Source: Transplantation Reviews)
Source: Transplantation Reviews - January 13, 2015 Category: Transplant Surgery Authors: Eva Girmanova, Petra Hruba, Ondrej Viklicky Source Type: research
Deep vein thrombosis and pulmonary embolism after solid organ transplantation: an unresolved problem
Venous thromboembolism (VTE) is a major complication after solid organ transplantation (SOT), with an incidence that ranges from 2% to 34%. Besides genetic risk factors such as inherited thrombophilia, other specific risk factors for VTE in SOT recipients include impairment of fibrinolysis produced by corticosteroids, in vitro procoagulant effects of calcineurin inhibitors, endothelial damage due to cytomegalovirus infection, and specific surgical factors. Prevention strategies have not been systematically studied. (Source: Transplantation Reviews)
Source: Transplantation Reviews - December 17, 2014 Category: Transplant Surgery Authors: Berta Sáez-Giménez, Cristina Berastegui, Karina Loor, Manuel López Meseguer, Víctor Monforte, Carlos Bravo, Amparo Santamaría, Antonio Roman Source Type: research
Subscription Prices
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Source: Transplantation Reviews - December 14, 2014 Category: Transplant Surgery Source Type: research
Editorial Board
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Source: Transplantation Reviews - December 14, 2014 Category: Transplant Surgery Source Type: research
Contents
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Source: Transplantation Reviews - December 14, 2014 Category: Transplant Surgery Source Type: research
Instructions for Authors
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Source: Transplantation Reviews - December 14, 2014 Category: Transplant Surgery Source Type: research
Previous Issue
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Source: Transplantation Reviews - December 14, 2014 Category: Transplant Surgery Source Type: research
-acyl dopamine derivates as lead compound for implementation in transplantation medicine
Conjugates of fatty acids with ethanolamine, amino acids or monoamine neurotransmitters occur widely in nature giving rise to so-called endocannabinoids. Anandamide and 2-arachidonoyl glycerol are the best characterized endocannabinoids activating both cannabinoid receptors (CB1 and CB2) and transient receptor potential vanilloid type 1 (TRPV1) channels (anandamide) or activating cannabinoid receptors only (2-arachidonoyl glycerol). TRPV1 is also activated by vanilloids, such as capsaicin, and endogenous neurolipins, e.g. (Source: Transplantation Reviews)
Source: Transplantation Reviews - December 11, 2014 Category: Transplant Surgery Authors: Johannes Wedel, Prama Pallavi, Eleni Stamellou, Benito A. Yard Source Type: research
Genomic and Proteomic Fingerprints of Acute Rejection in Peripheral Blood and Urine
Acute dysfunction of a kidney transplant can be the result of many different etiologies and an allograft biopsy is frequently necessary to diagnose acute rejection. This invasive procedure, while generally safe, is time consuming, costly and inconvenient. We summarize recent advances in genomic and proteomic techniques using peripheral blood and urine for the diagnosis of acute rejection. While much progress has been made, validation of these new molecular tests in the clinical setting is still required. (Source: Transplantation Reviews)
Source: Transplantation Reviews - December 11, 2014 Category: Transplant Surgery Authors: Song Ong, Roslyn B. Mannon Source Type: research
N-acyl dopamine derivates as lead compound for implementation in transplantation medicine
Conjugates of fatty acids with ethanolamine, amino acids or monoamine neurotransmitters occur widely in nature giving rise to so-called endocannabinoids. Anandamide and 2-arachidonoyl glycerol are the best characterized endocannabinoids activating both cannabinoid receptors (CB1 and CB2) and transient receptor potential vanilloid type 1 (TRPV1) channels (anandamide) or activating cannabinoid receptors only (2-arachidonoyl glycerol). TRPV1 is also activated by vanilloids, such as capsaicin, and endogenous neurolipins, e.g. (Source: Transplantation Reviews)
Source: Transplantation Reviews - December 11, 2014 Category: Transplant Surgery Authors: Johannes Wedel, Prama Pallavi, Eleni Stamellou, Benito A. Yard Source Type: research
A systematic review of the use of rituximab as induction therapy in renal transplantation
Rituximab is a B-lymphocyte depleting agent used to treat lymphoma and autoimmune diseases. There has been recent interest in its use both for management of highly-sensitised and ABO-incompatible recipients but also for induction therapy before transplantation. This systematic review evaluates the evidence for its use as part of induction protocols in ABO-compatible, non-sensitised recipients. 4 databases and 3 trial registries were searched for studies of the use of rituximab as part of induction protocols. (Source: Transplantation Reviews)
Source: Transplantation Reviews - December 5, 2014 Category: Transplant Surgery Authors: Philip S. Macklin, Peter J. Morris, Simon R. Knight Source Type: research
Liver Transplantation in Turkey: Historical review and future perspectives
Since the first successful liver transplantation by Starzl et al in 1967, liver transplantation has become the standard therapy for many liver diseases, mainly chronic liver disease. Most liver transplantations performed in Europe and North America utilize deceased donors while a considerable portion of organ requirements is supplied by living donors in Asian countries including Turkey. The actual history of solid organ transplantation in Turkey began with the pioneering work of Dr. Haberal in collaboration with Thomaz E. (Source: Transplantation Reviews)
Source: Transplantation Reviews - December 5, 2014 Category: Transplant Surgery Authors: Sami Akbulut, Sezai Yilmaz Source Type: research
